N-丁酰基-N-丁基脲 | 23549-53-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: N-丁酰基-N-丁基脲
• 英文名称: N-carbamoylbutyramide
• 英文别名: butyrylurea；n-butyrylurea；butyryl-urea；Buttersaeure-ureid；Butyryl-harnstoff；Monobutyryl-harnstoff；Butanamide, N-(aminocarbonyl)-；N-carbamoylbutanamide
• CAS: 23549-53-3
• 化学式: C₅H₁₀N₂O₂
• 分子量: 130.147
• InChiKey: ZTMFJNLOLCXQPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924210090

反应信息

• 作为反应物：
  描述：

  N-丁酰基-N-丁基脲 、 二乙基丙二酸二乙酯 在 sodium ethanolate 作用下， 生成 5,5-二乙基丙二酰脲
  参考文献：
  名称：

  DE147278

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N'-dibutyryl-urea 在 水 作用下， 生成 N-丁酰基-N-丁基脲
  参考文献：
  名称：

  Werner, Scientific Proceedings of the Royal Dublin Society, 1943, vol. 23, p. 132,133

  摘要：

  DOI：

文献信息

• Group interviews with people taking long-term medication: comparing the perspectives of people with arthritis, respiratory disease and mental health problems
  作者：Felicity Smith、Sally-Anne Francis、Emma Rowley

  DOI：10.1111/j.2042-7174.2000.tb00991.x

  日期：2011.2.22

  To examine experiences of medicine use, advice and support from the perspectives of people taking medicines long term for arthritis, respiratory disease and mental health problems.

  Twelve group interviews were conducted, four with each of the three chronic illness groups.

  Interviews were arranged through national and local voluntary organisations and conducted as part of their regular meetings.

  The most prominent issue for all the Arthritis Care groups was information about side effects. People discussed the benefits of having this information and the reasons they believed that it was not generally provided. People with respiratory disease described difficulties of obtaining information as a problem in the operation of the health service in Britain, where participants may or may not find out about different products by chance. In all these discussions there were examples of how people used their regular group meetings to inform each other. For people with mental health problems, participation in decisions concerning medicines and the attitudes of health professionals were the most prominent issues. Members of all groups, across all chronic illnesses, claimed that adequate information was not shared with them during consultations with professionals. However, different perspectives of involvement in decision-making regarding therapy were distinguishable. Pharmacy services did not feature prominently in any of the group discussions.

  The study revealed differences between the illness groups in the emphasis participants placed on different issues. However, there were also common concerns, in particular relating to obtaining information and the attitudes of professionals. While pharmacy services were not prominent in discussions, a range of unmet needs concerning medicines were identified. This indicates that opportunities exist for pharmacists to provide more responsive services that would be valued by people taking long-term medication.

  从长期服用药物治疗关节炎、呼吸道疾病和心理健康问题的人的角度，探讨药物使用经验、建议和支持。

  进行了十二次小组访谈，每种慢性疾病群体各四次。

  通过国家和当地志愿组织安排了访谈，并作为他们定期会议的一部分进行。

  对于所有关节炎护理小组来说，最突出的问题是有关副作用的信息。人们讨论了获得这些信息的好处以及他们认为通常不提供这些信息的原因。患有呼吸道疾病的人描述了在英国卫生服务运作中获得信息的困难，参与者可能或可能不会偶然发现不同产品的情况。在所有这些讨论中，都有人们如何利用定期小组会议相互通知的例子。对于患有心理健康问题的人来说，参与药物决策和卫生专业人员的态度是最突出的问题。所有慢性疾病群体的成员声称在与专业人员的咨询中未能分享足够的信息。然而，在治疗决策方面有不同的参与观点。药房服务在任何小组讨论中都没有显著特色。

  研究揭示了患病群体在强调不同问题方面的差异。然而，也存在共同的关注点，特别是有关获取信息和专业人员态度的问题。虽然药房服务在讨论中并不突出，但发现了有关药物的一系列未满足需求。这表明药剂师有机会提供更加贴心的服务，这将受到长期服药的人们的重视。

• Copper(II)-Catalyzed Reactions of α-Keto Thioesters with Azides via C–C and C–S Bond Cleavages: Synthesis of <i>N</i>-Acylureas and Amides
  作者：Rajib Maity、Sandip Naskar、Indrajit Das

  DOI：10.1021/acs.joc.7b03054

  日期：2018.2.16

  Cu(II)-catalyzed reaction of α-keto thioesters with trimethylsilyl azide (TMSN3) proceeds with the transformation of the thioester group into urea through C–C and C–S bond cleavages, constituting a practical and straightforward synthesis of N-acylureas. When diphenyl phosphoryl azide (DPPA) is used instead as the azide source in an aqueous environment, primary amides are formed via substitution of

  Cu（II）催化α-酮硫代酸酯与三甲基硅烷基叠氮化物（TMSN 3）的反应是通过C-C和C-S键断裂将硫代酯基团转化为尿素，从而构成了一种实用而直接的N合成方法-酰基脲。当在水性环境中使用二苯基磷酰基叠氮化物（DPPA）作为叠氮化物来源时，伯酰胺是通过硫代酯基团的取代而形成的。建议反应通过最初形成的α-酮酰基叠氮化物的库尔修斯重排进行以产生酰基异氰酸酯中间体，其与额外量的叠氮化物或水进一步反应并重排以提供相应的产物。为了证明该方法的潜力，已经进行了一步合成的显示抗惊厥活性的吡咯乙脲和异戊脲。
• Stoughton, Journal of Organic Chemistry, 1937, vol. 2, p. 518
  作者：Stoughton

  DOI：——

  日期：——
• Zirvi; Fakouhi, Farmaco, Edizione Scientifica, 1982, vol. 37, # 5, p. 335 - 342
  作者：Zirvi、Fakouhi

  DOI：——

  日期：——
• Moldenhauer, Justus Liebigs Annalen der Chemie, 1855, vol. 94, p. 100
  作者：Moldenhauer

  DOI：——

  日期：——

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