1-Dodecylaminomethyl-3-hydroxymethyl-urea | 595545-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-Dodecylaminomethyl-3-hydroxymethyl-urea
• 英文别名: N-[(Dodecylamino)methyl]-N'-(hydroxymethyl)urea；1-[(dodecylamino)methyl]-3-(hydroxymethyl)urea
• CAS: 595545-97-4
• 化学式: C₁₅H₃₃N₃O₂
• 分子量: 287.446
• InChiKey: DPWJQDWBLGOJEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  73.4
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  十二烷基伯胺 、 1'3-双羟甲基脲 在 Sodium tetraborate decahydrate 作用下， 反应 1.5h， 生成 1-Dodecylaminomethyl-3-hydroxymethyl-urea
  参考文献：
  名称：

  羟甲基尿素对囊泡的表面修饰

  摘要：

  AbstractSurface‐modified vesicles were prepared using N‐[3‐(dimethylamino)propyl]‐octadecanamide and stearic acid as bilayer‐forming lipids, and N‐methylol urea‐dodecylamine conjugated (MU‐DOA) as a surface modifier. The conjugation of MU to DOA was confirmed by FTIR spectra. MU‐DOA was incorporated into the vesicles by co‐homogenization of the lipids and MU‐DOA, and the incorporated MU‐DOA was then reacted with MU in aqueous bulk phase through a self‐condensation reaction between the methylols under an acidic condition at 70°C. On a scanning electron microscope, the vesicles were spherical and multilamellar, and they exhibited thin polymer films on their surfaces. The incorporation of MU‐DOA into the bilayer and the surface coating of the vesicles did not significantly influence the transition temperature of the vesicles. The absolute values of zeta potentials of the surface‐modified vesicles were smaller than those of the unmodified vesicles, and the point of zero charge was shifted from ca. pH 9.5 to ca pH 6.5 by the surface modification.

  DOI：

  10.1007/s11746-002-0633-0

文献信息

• Surface modification of vesicles with methylol urea
  作者：Jin-Chul Kim、Jong-Duk Kim

  DOI：10.1007/s11746-002-0633-0

  日期：2002.12

  AbstractSurface‐modified vesicles were prepared using N‐[3‐(dimethylamino)propyl]‐octadecanamide and stearic acid as bilayer‐forming lipids, and N‐methylol urea‐dodecylamine conjugated (MU‐DOA) as a surface modifier. The conjugation of MU to DOA was confirmed by FTIR spectra. MU‐DOA was incorporated into the vesicles by co‐homogenization of the lipids and MU‐DOA, and the incorporated MU‐DOA was then reacted with MU in aqueous bulk phase through a self‐condensation reaction between the methylols under an acidic condition at 70°C. On a scanning electron microscope, the vesicles were spherical and multilamellar, and they exhibited thin polymer films on their surfaces. The incorporation of MU‐DOA into the bilayer and the surface coating of the vesicles did not significantly influence the transition temperature of the vesicles. The absolute values of zeta potentials of the surface‐modified vesicles were smaller than those of the unmodified vesicles, and the point of zero charge was shifted from ca. pH 9.5 to ca pH 6.5 by the surface modification.