1,2-Dicyclohexyl-isoharnstoff | 91972-87-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 甲亚胺酸及其衍生物
• 英文名称: 1,2-Dicyclohexyl-isoharnstoff
• 英文别名: cyclohexyl N-cyclohexylimidocarbamate；cyclohexyl N'-cyclohexylcarbamimidate
• CAS: 91972-87-1
• 化学式: C₁₃H₂₄N₂O
• 分子量: 224.346
• InChiKey: RTTHFYIIJABMES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  溴化氰 、 环己胺 、 环己醇 生成 1,2-Dicyclohexyl-isoharnstoff
  参考文献：
  名称：

  STRUCTURES OF CYCLOHEXANONE–UREA CONDENSATION PRODUCTS

  摘要：

  通过将环己酮与尿素、硫脲及它们的单取代衍生物缩合，制备了一系列新的脲衍生物。

  DOI：

  10.1139/v62-215

文献信息

• [EN] NOVEL INTERMEDIATES FOR THE SYNTHESIS OF (R)-TAMSULOSIN AND OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THEIR PREPARATION<br/>[FR] NOUVEAUX INTERMEDIAIRES DESTINES A LA SYNTHESE DE LA (R)-TAMSULOSINE ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES, ET LEUR PROCEDE DE PREPARATION
  申请人：PROD CHIM AUXILIAIRES ET DE SY

  公开号：WO2005058810A1

  公开（公告）日：2005-06-30

  A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

  本发明的主题是(R)-坦索洛辛及其药用盐的合成新中间体，以及相关的制备过程。
• NUCLEIC ACID TERMINATORS INCORPORATING A CATIONIC MOIETY AND METHODS FOR THEIR USE
  申请人：Rosenblum Barnett B.

  公开号：US20090246762A1

  公开（公告）日：2009-10-01

  Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.

  揭示了适用于测序方法的方法和试剂盒，例如桑格二氧基测序方法。所述方法和试剂盒利用带正电荷的核酸终止剂与具有区别性的聚合酶相结合。
• Cyclodextrin-based materials, compositions and uses related thereto
  申请人：Insert Therapeutics, Inc.

  公开号：US20040109888A1

  公开（公告）日：2004-06-10

  This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.

  本申请公开了用于携带药物和其他活性剂（例如核酸）的环糊精修饰材料。还公开了环糊精修饰材料的组合物，在受控条件下释放这些活性剂。该发明还公开了环糊精修饰高分子载体的组合物，该载体与生物识别分子耦合，以协助将药物输送到其作用部位。
• Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
  申请人：Dambrin Valéry

  公开号：US20070106079A1

  公开（公告）日：2007-05-10

  A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

  本发明的主题是一种合成(R)-坦索罗辛及其药用可接受盐的新型中间体，以及相关的制备工艺。
• Nucleic Acid Terminators Incorporating a Cationic Moiety and Methods for Their Use
  申请人：Rosenblum Barnett B.

  公开号：US20100035326A1

  公开（公告）日：2010-02-11

  Disclosed are methods and kits applicable to sequencing methods, such as Sanger dideoxy sequencing methods. The methods and kits disclosed utilize a cationically charged nucleic acid terminator in combination with a discriminatory polymerase.

  公开了适用于测序方法的方法和试剂盒，例如Sanger二氧化二脱氧测序方法。所公开的方法和试剂盒利用带正电荷的核酸终止剂与具有选择性的聚合酶结合。