1α-hydroxy-25-oxa-25-phospha-26,27-dioxa-26,27-dimethylvitamin D₃ | 137548-45-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1α-hydroxy-25-oxa-25-phospha-26,27-dioxa-26,27-dimethylvitamin D₃
• 英文别名: 1alpha-hydroxy-24-(dimethoxyphosphoryl)-25,26,27-trinorvitamin D3/1alpha-hydroxy-24-(dimethoxyphosphoryl)-25,26,27-trinorcholecalciferol；(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-5-dimethoxyphosphorylpentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• CAS: 137548-45-9
• 化学式: C₂₆H₄₃O₅P
• 分子量: 466.598
• InChiKey: RWBIHPUGBYXCAN-KPJOBTTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1R,3aR,7aR)-1-[(2R)-5-dimethoxyphosphorylpentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-one 在 正丁基锂 、 四丁基氟化铵 作用下， 生成 1α-hydroxy-25-oxa-25-phospha-26,27-dioxa-26,27-dimethylvitamin D₃
  参考文献：
  名称：

  25-Phosphorus analogs of vitamin D3

  摘要：

  The syntheses 1-alpha-hydroxy-25-oxo-25-phosphavitamin D3, 25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3, and 1-alpha-hydroxy-25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3 are reported. The biological activity of 25-oxo-25-phosphavitamin D3 and the above compounds are reported.

  DOI：

  10.1016/s0040-4039(00)92270-6

文献信息

• 25-Phosphorus analogs of vitamin D3
  作者：William G. Dauben、Richard R. Ollmann、Angelika S. Funhoff、Suzanne S. Leung、Anthony W. Norman、June E. Bishop

  DOI：10.1016/s0040-4039(00)92270-6

  日期：1991.1

  The syntheses 1-alpha-hydroxy-25-oxo-25-phosphavitamin D3, 25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3, and 1-alpha-hydroxy-25-oxo-25-phospha-26,27-dioxa-26,27-dimethylvitamin D3 are reported. The biological activity of 25-oxo-25-phosphavitamin D3 and the above compounds are reported.