2-[(1,4-dioxo-2-naphthyl)sulfanyl]-N-phenyl-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(1,4-dioxo-2-naphthyl)sulfanyl]-N-phenyl-acetamide
• 英文别名: 2-(1,4-dioxonaphthalen-2-yl)sulfanyl-N-phenylacetamide
• 化学式: C₁₈H₁₃NO₃S
• 分子量: 323.372
• InChiKey: NHRZEWNQIFSXGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  88.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  S-(1,4-naphthoquinon-2-yl)mercaptoacetic acid 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 2-[(1,4-dioxo-2-naphthyl)sulfanyl]-N-phenyl-acetamide
  参考文献：
  名称：

  Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents

  摘要：

  A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.075