2-methyl-4-naphthalen-2-yl-2-phenyl-6-thiophen-3-yl-2H-1,3-oxazine | 1202553-56-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-methyl-4-naphthalen-2-yl-2-phenyl-6-thiophen-3-yl-2H-1,3-oxazine
• 英文别名: 2-Methyl-4-naphthalen-2-yl-2-phenyl-6-thiophen-3-yl-1,3-oxazine；2-methyl-4-naphthalen-2-yl-2-phenyl-6-thiophen-3-yl-1,3-oxazine
• CAS: 1202553-56-7
• 化学式: C₂₅H₁₉NOS
• 分子量: 381.498
• InChiKey: SXQMJTMBQAVUST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Naphthalen-2-yl-3-thiophen-3-ylprop-2-yn-1-one 、 (S)-2-叠氮基-2-苯基乙醇 在 三丁基膦 作用下， 以 甲苯 为溶剂， 反应 14.0h， 以87%的产率得到2-methyl-4-naphthalen-2-yl-2-phenyl-6-thiophen-3-yl-2H-1,3-oxazine
  参考文献：
  名称：

  A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines

  摘要：

  A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.

  DOI：

  10.1021/ol9024309

文献信息

• A Phosphine-Mediated Construction of 1,4-Oxazepines and 1,3-Oxazines
  作者：Céline François-Endelmond、Thomas Carlin、Pierre Thuery、Olivier Loreau、Frédéric Taran

  DOI：10.1021/ol9024309

  日期：2010.1.1

  A simple and efficient method for constructing 1,4-oxazepines and 1,3-oxazines was developed with use of a phosphine-mediated tandem reaction of ynones with 2-azido alcohols. The method offers a promising route to synthetically useful as well as biologically active heterocycles under mild conditions and may be exploited for the preparation of interesting chiral ligands.