N-乙氧基羰基哌啶-4-膦酸二乙酯 | 216870-24-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-乙氧基羰基哌啶-4-膦酸二乙酯
• 英文名称: diethyl N-ethoxycarbonylpiperidine-4-phosphonate
• 英文别名: 4-(Diethoxyphosphoryl)-piperidine-1-carboxylic acid ethyl ester；ethyl 4-diethoxyphosphorylpiperidine-1-carboxylate
• CAS: 216870-24-5
• 化学式: C₁₂H₂₄NO₅P
• 分子量: 293.3
• InChiKey: WIDSLWVFIHWGMP-UHFFFAOYSA-N

物化性质

• 沸点：
  386.0±31.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-乙氧基羰基哌啶-4-膦酸二乙酯 在 盐酸 作用下， 以 N,N-二甲基乙酰胺 、 异丙醇 为溶剂， 20.0~140.0 ℃ 、101.33 kPa 条件下， 反应 2.0h， 以82%的产率得到氯雷他定
  参考文献：
  名称：

  [EN] NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE
  [FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE LORATADINE À PARTIR D'UN INTERMÉDIAIRE DE CÉTONE

  摘要：

  公开号：

  WO2015084693A3
• 作为产物：
  描述：

  diethyl 1-ethoxycarbonyl-1,4-dihydroxypyridine-4-phosphonate 以88的产率得到N-乙氧基羰基哌啶-4-膦酸二乙酯
  参考文献：
  名称：

  [EN] NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE
  [FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE LORATADINE À PARTIR D'UN INTERMÉDIAIRE DE CÉTONE

  摘要：

  本申请涉及一种从酮中间体制备洛拉替定的最后步合成过程。

  公开号：

  WO2015084693A2

文献信息

• PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY
  申请人：SCHERING CORPORATION

  公开号：EP1140899B1

  公开（公告）日：2003-09-10
• Kehler, Jan; Ebert, Bjarke; Dahl, Otto, Journal of the Chemical Society. Perkin transactions I, 1998, # 19, p. 3241 - 3243
  作者：Kehler, Jan、Ebert, Bjarke、Dahl, Otto、Krogsgaard-Larsen, Povl

  DOI：——

  日期：——
• US6271378B1
  申请人：——

  公开号：US6271378B1

  公开（公告）日：2001-08-07
• [EN] PROCESS FOR PREPARING TRICYCLIC COMPOUNDS HAVING ANTIHISTAMINIC ACTIVITY<br/>[FR] PROCEDE DE PREPARATION DE COMPOSES TRICYCLIQUES AYANT UNE ACTIVITE ANTIHISTAMINIQUE
  申请人：SCHERING CORP

  公开号：WO2000037457A1

  公开（公告）日：2000-06-29

  Disclosed is a process for preparing a compound having formula (I) wherein R1 is selected from the group consisting of: alkyl, alkenyl, alkynyl, aryl, aralkyl, cycloalkyl, and cycloalkyalkyl, R1 being optionally substituted by substituents selected from halo, -OH, alkyl, alkoxy, or -CF¿3?, said process comprising the following steps: (a) reacting a ketone having formula (A) with a carbanion having formula (B) wherein R?1¿ is defined above, and R?2 and R3¿ are independently selected from the group consisting of -OR?A and -RA¿; wherein RA is alkyl, phenyl, substituted phenyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, or substituted cycloalkylalkyl; (b) treating the reaction mixture from step (a) with a protonating agent to form a β-hydroxy intermediate having formula (C) wherein R?1, R2 and R3¿ are as defined above; and (c) thermally decomposing the β-hydroxy intermediate to form the compound of formula (I). The compounds made by this process have antihistaminic activity, e.g., loratadine. Also disclosed is a process for preparing descarboethoxyloratadine, by carrying out the process above, and converting the product to descarboethoxyloratadine. Also disclosed are novel intermediates having formula (II) and (III) wherein R?1, R2 and R3¿ are as defined above.
• [EN] NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE<br/>[FR] NOUVEAU PROCÉDÉ DE PRÉPARATION DE LORATADINE À PARTIR D'UN INTERMÉDIAIRE DE CÉTONE
  申请人：MERCK SHARP & DOHME

  公开号：WO2015084693A3

  公开（公告）日：2015-10-22