25-(OH)D₃

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 25-(OH)D₃
• 英文别名: 25-hydroxyvitamin D₃；3-Deoxy-1alpha,25-dihydroxyvitamin D3；3-deoxy-1α,25-dihydroxycholecalciferol；1alpha,25-dihydroxy-3-deoxyvitamin D3/1alpha,25-dihydroxy-3-deoxycholecalciferol；(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidenecyclohexan-1-ol
• 化学式: C₂₇H₄₄O₂
• 分子量: 400.645
• InChiKey: SMHOCVXBTUJVBK-FBXCIANDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Methods for detecting binding of low-molecular-weight compound and its binding partner molecule
  申请人：Esaki Keiko

  公开号：US20050084908A1

  公开（公告）日：2005-04-21

  A method for detecting the binding between a binding molecule and an immobilized low-molecular-weight compound is provided. The method comprises a step of measuring volume changes due to the binding of both compounds as an indicator. The use of immobilized low-molecular-weight compound produces highly reliable measuring results in terms of surface plasmon resonance, etc. The detection method of this invention is useful for screening for low-molecular-weight compounds that bind to binding molecules, or binding molecules that bind to low-molecular-weight compounds.

  提供了一种检测结合分子和固定低分子量化合物之间结合的方法。该方法包括测量由于两种化合物结合而产生的体积变化作为指标的步骤。使用固定低分子量化合物可在表面等离子共振等方面产生高度可靠的测量结果。本发明的检测方法对于筛选结合到低分子量化合物的结合分子或结合到结合分子的低分子量化合物非常有用。
• PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF SECONDARY HYPERPARATHYROIDISM AND THERAPEUTIC AGENTS FOR CARDIOVASCULAR COMPLICATIONS RESULTING FROM THE TREATMENT FOR SECONDARY HYPERPARATHYROIDISM.
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1402893A1

  公开（公告）日：2004-03-31

  An object of the present invention is to provide a pharmaceutical composition for the treatment of secondary hyperparathyroidism, which can reduce the risk of inducing cardiovascular complications associated with calcification, as well as a therapeutic or prophylactic agent for cardiovascular complications (e.g., arteriosclerosis, ischemic heart disease) associated with calcification resulting from the treatment of secondary hyperparathyroidism in a hemodialysis patient. The present invention provides a pharmaceutical composition for the treatment of secondary hyperparathyroidism, which comprises, as an active ingredient, a vitamin D derivative not having an inducing action on cardiovascular complications associated with calcification, as well as a therapeutic agent for cardiovascular complications associated with calcification resulting from the treatment of secondary hyperparathyroidism in a hemodialysis patient, which comprises 1α,3β-dihydroxy-20S-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10(19)-pregnatriene as an active ingredient.

  本发明的目的是提供一种用于治疗继发性甲状旁腺功能亢进症的药物组合物，它可以降低诱发与钙化相关的心血管并发症的风险，同时也是一种治疗或预防血液透析患者因治疗继发性甲状旁腺功能亢进症而导致的与钙化相关的心血管并发症（如动脉硬化、缺血性心脏病）的药物。 本发明提供了一种用于治疗继发性甲状旁腺功能亢进症的药物组合物，其作为一种活性成分，包含一种对与钙化相关的心血管并发症不具有诱导作用的维生素 D 衍生物、以及一种治疗血液透析患者因治疗继发性甲状旁腺功能亢进症而引起的与钙化相关的心血管并发症的治疗剂，其活性成分包括1α,3β-二羟基-20S-(3-羟基-3-甲基丁酰氧基)-9,10-seco-5,7,10(19)-孕三烯。
• Medicinal compositions for treating secondary parathyroid hyperfunction and remedies for cardiovascular complications in association with treatment for secondary parathyroid hyperfunction
  申请人：——

  公开号：US20040248859A1

  公开（公告）日：2004-12-09

  An object of the present invention is to provide a pharmaceutical composition for the treatment of secondary hyperparathyroidism, which can reduce the risk of inducing cardiovascular complications associated with calcification, as well as a therapeutic or prophylactic agent for cardiovascular complications (e.g., arteriosclerosis, ischemic heart disease) associated with calcification resulting from the treatment of secondary hyperparathyroidism in a hemodialysis patient. The present invention provides a pharmaceutical composition for the treatment of secondary hyperparathyroidism, which comprises, as an active ingredient, a vitamin D derivative not having an inducing action on cardiovascular complications associated with calcification, as well as a therapeutic agent for cardiovascular complications associated with calcification resulting from the treatment of secondary hyperparathyroidism in a hemodialysis patient, which comprises 1&agr;,3&bgr;-dihydroxy-20S-(3-hydroxy-3-methylbutyloxy)-9,10-seco-5,7,10(19)-pregnatriene as an active ingredient.

  本发明的目的是提供一种用于治疗继发性甲状旁腺功能亢进症的药物组合物，它可以降低诱发与钙化相关的心血管并发症的风险，同时也是一种治疗或预防血液透析患者因治疗继发性甲状旁腺功能亢进症而导致的与钙化相关的心血管并发症（如动脉硬化、缺血性心脏病）的药物。 本发明提供了一种用于治疗继发性甲状旁腺功能亢进症的药物组合物，其作为一种活性成分，包括一种对与钙化相关的心血管并发症不具有诱导作用的维生素 D 衍生物，以及一种治疗血液透析患者因治疗继发性甲状旁腺功能亢进症而导致的与钙化相关的心血管并发症的治疗剂，其包括 1&agr；,3&bgr;-二羟基-20S-(3-羟基-3-甲基丁酰氧基)-9,10-seco-5,7,10(19)-孕三烯作为活性成分。
• US4264512A
  申请人：——

  公开号：US4264512A

  公开（公告）日：1981-04-28