15,16-Dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17,19-octaene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 15,16-Dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17,19-octaene
• 化学式: C₁₉H₁₅NO₄
• 分子量: 321.3
• InChiKey: LXDREMZQGAILJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Methods for reactivating genes on the inactive X chromosome
  申请人：The General Hospital Corporation

  公开号：US10961532B2

  公开（公告）日：2021-03-30

  Methods for reactivating genes on the inactive X chromosome that include administering one or both of a DNA methyltransferase (DNMT) Inhibitor and/or a topoisomerase inhibitor, e.g., etoposide and/or 5-azacytidine (aza), optionally in combination with an inhibitor of XIST RNA and/or an Xist-interacting protein, e.g., a chromatin-modifying protein, e.g., a small molecule or an inhibitory nucleic acid (such as a small inhibitory RNA (siRNAs) or antisense oligonucleotide (ASO)) that targets XIST RNA and/or a gene encoding an Xist-interacting protein, e.g., a chromatin-modifying protein.

  重新激活无活性 X 染色体上基因的方法，包括施用 DNA 甲基转移酶（DNMT）抑制剂和/或拓扑异构酶抑制剂（如依托泊苷和/或 5-氮杂胞苷（azacytidine，aza））中的一种或两种，可选择与 XIST RNA 抑制剂和/或 Xist 交互蛋白（如染色质修饰蛋白）结合使用、染色质修饰蛋白，如靶向 XIST RNA 和/或 Xist 交互作用蛋白（如染色质修饰蛋白）编码基因的小分子或抑制性核酸（如小抑制性 RNA (siRNAs) 或反义寡核苷酸 (ASO)）。
• METHODS FOR REACTIVATING GENES ON THE INACTIVE X CHROMOSOME
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP3283502A1

  公开（公告）日：2018-02-21
• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• [EN] METHODS FOR REACTIVATING GENES ON THE INACTIVE X CHROMOSOME<br/>[FR] PROCÉDÉS DE RÉACTIVATION DE GÈNES SUR LE CHROMOSOME X INACTIF
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2016164463A1

  公开（公告）日：2016-10-13

  Methods for reactivating genes on the inactive X chromosome that include administering one or both of a DNA methyltransferase (DNMT) Inhibitor and/or a topoisomerase inhibitor, e.g., etoposide and/or 5-azacytidine (aza), optionally in combination with an inhibitor of XIST RNA and/or an Xist-interacting protein, e.g., a chromatin-modifying protein, e.g., a small molecule or an inhibitory nucleic acid (such as a small inhibitory RNA (siRNAs) or antisense oligonucleotide (ASO)) that targets XIST RNA and/or a gene encoding an Xist-interacting protein, e.g., a chromatin-modifying protein.