Dibenzo[b,f]oxepin-3-amine, 10,11-dihydro-6-methoxy-

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: Dibenzo[b,f]oxepin-3-amine, 10,11-dihydro-6-methoxy-
• 英文别名: 10-methoxy-5,6-dihydrobenzo[b][1]benzoxepin-2-amine
• 化学式: C₁₅H₁₅NO₂
• 分子量: 241.28
• InChiKey: NVKBWIOTLFBPNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-methoxy-3-nitrodibenzo[b,f]oxepine 在 hydrazine hydrate 、 palladium 10% on activated carbon 作用下， 以76 %的产率得到Dibenzo[b,f]oxepin-3-amine, 10,11-dihydro-6-methoxy-
  参考文献：
  名称：

  AMINE DERIVATIVES OF DIHYDRODIBENZO[ b,ƒ ]OXEPINES AND METHOD OF PREPARATION THEREOF

  摘要：

  The subject matter of the invention are dihydrodibenzo[b,f]oxepine derivatives having a general formula (1) and a method of preparation thereof, characterised by the fact that methoxynitrodibenzo[b,ƒ]oxepine having a formula (2) is mixed with a catalyst in a molar ratio of 1:4 in an organic solvent, a mixture is then heated at the boiling point of the solvent for 5 minutes, followed by adding dropwise a hydrazine monohydrate slowly to the reaction mixture and is stirred for further 30 minutes at the boiling point, the post-reaction mixture is then filtered and washed twice with ethanol, and the resulting filtrate is left at the temperature -15°C for 24 hours, followed by separation of the final product therefrom by means of filtration under reduced pressure.

  公开号：

  WO2024162861A1

文献信息

• AMINE DERIVATIVES OF DIHYDRODIBENZO[ b,ƒ ]OXEPINES AND METHOD OF PREPARATION THEREOF
  申请人：[en]POLITECHNIKA WARSZAWSKA

  公开号：WO2024162861A1

  公开（公告）日：2024-08-08

  The subject matter of the invention are dihydrodibenzo[b,f]oxepine derivatives having a general formula (1) and a method of preparation thereof, characterised by the fact that methoxynitrodibenzo[b,ƒ]oxepine having a formula (2) is mixed with a catalyst in a molar ratio of 1:4 in an organic solvent, a mixture is then heated at the boiling point of the solvent for 5 minutes, followed by adding dropwise a hydrazine monohydrate slowly to the reaction mixture and is stirred for further 30 minutes at the boiling point, the post-reaction mixture is then filtered and washed twice with ethanol, and the resulting filtrate is left at the temperature -15°C for 24 hours, followed by separation of the final product therefrom by means of filtration under reduced pressure.