N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]quinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[2-(1-methylpiperidin-4-yl)ethoxy]quinazolin-4-amine
• 化学式: C₂₃H₂₆ClFN₄O₂
• 分子量: 444.9
• InChiKey: VEOIWTSZBRXBQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  59.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Methods for Identifying Risk of Type II Diabetes and Treatments Thereof
  申请人：Langdown Maria L.

  公开号：US20080199480A1

  公开（公告）日：2008-08-21

  Provided herein are methods for identifying a risk of type II diabetes in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating type II diabetes, and therapeutic and preventative methods applicable to type II diabetes. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.