N'-[(Z)-(3-hydroxyphenyl)methylideneamino]pyridine-2-carboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N'-[(Z)-(3-hydroxyphenyl)methylideneamino]pyridine-2-carboximidamide
• 化学式: C₁₃H₁₂N₄O
• 分子量: 240.26
• InChiKey: PEWSUTOUDLXWHN-SXGWCWSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION
  申请人：Ossowski Liliana

  公开号：US20100249184A1

  公开（公告）日：2010-09-30

  The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject.