N-(Isopropyl)-N-bis-(γ-hydroxypropyl)-amin | 34753-59-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(Isopropyl)-N-bis-(γ-hydroxypropyl)-amin
• 英文别名: 3,3'-[(Propan-2-yl)azanediyl]di(propan-1-ol)；3-[3-hydroxypropyl(propan-2-yl)amino]propan-1-ol
• CAS: 34753-59-8
• 化学式: C₉H₂₁NO₂
• 分子量: 175.271
• InChiKey: DPPZPKDTOZZIRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,3'-isopropylimino-di-propionic acid diethyl ester 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 15.0h， 以83%的产率得到N-(Isopropyl)-N-bis-(γ-hydroxypropyl)-amin
  参考文献：
  名称：

  Lithium Aluminum Hydride Reductions; A New Hydrolysis Method for Intractable Products

  摘要：

  本文介绍了一种新的氢化铝锂还原水解程序，该程序可使多功能产品的合成技术更简单，产量显著提高。该程序通过还原一系列甲酰胺和氨基酯得到各种丙醇胺来说明。

  DOI：

  10.1055/s-1986-31609

文献信息

• Photopolymerisierbares Aufzeichnungsmaterial und Verfahren zur Herstellung von Reliefformen mittels dieses Aufzeichnungsmaterials
  申请人：BASF Aktiengesellschaft

  公开号：EP0054150A1

  公开（公告）日：1982-06-23

  Photopolymerisierbare Aufzeichnungsmaterialien zur Herstellung von Reliefformen mit einem Schichtträger und einer photopolymerisierbaren Schicht enthalten in der photopolymerisierbaren Schicht als Bindemittel ein im wesentlichen lineares, bei Raumtemperatur festes, hochmolekulares, thermoplastisches Polyurethan, das seitenständige photopolymerisierbare Doppelbindungen und quaternäre und/ oder quaternisiserbare Stickstoffatome eingebaut enthält.

  用于制作浮雕形状的可光聚合记录材料，具有一层支撑层和一层可光聚合层，在可光聚合层中含有一种基本上是线性的高分子热塑性聚氨酯作为粘合剂，这种聚氨酯在室温下是固体，含有可光聚合双键和季氮原子和/或季氮原子。
• VINYL-URETHANE COPOLYMER AND METHOD FOR PRODUCING SAME
  申请人：KONISHI CO., LTD.

  公开号：EP1837360A1

  公开（公告）日：2007-09-26

  To provide vinyl-urethane copolymers that can form cured articles having excellent hot-water resistance, water resistance, heat resistance, and weather resistance, and to provide production methods thereof. A vinyl-urethane copolymer contains at least one vinyl polymer chain and at least one urethane polymer chain, in which the vinyl polymer chain is combined with the urethane polymer chain through a linkage segment having a silicon-oxygen bond. A method produces a vinyl-urethane copolymer comprising at least one vinyl polymer chain and at least one urethane polymer chain, in which the vinyl polymer chain is combined with the urethane polymer chain through a linkage segment having a silicon-oxygen bond, by following Steps (X) and (Y): Step (X) of carrying out preparation of an aqueous dispersion or aqueous solution of a urethane polymer (A) having at least one silicon-containing hydrolyzable group; and Step (Y) of, in the aqueous dispersion or aqueous solution of the urethane polymer (A) having at least one silicon-containing hydrolyzable group, carrying out polymerization of an ethylenically unsaturated monomer (B) and carrying out preparation of a vinyl-urethane copolymer using a compound (C) having at least one functional group reactive with a silicon-containing hydrolyzable group and at least one functional group reactive with an ethylenically unsaturated bond-containing group in at least one period selected from before the polymerization reaction, during the polymerization reaction, and after the polymerization reaction.

  提供可形成具有优异耐热水性、耐水性、耐热性和耐候性的固化物的乙烯基-聚氨酯共聚物，并提供其生产方法。 乙烯基-聚氨酯共聚物包含至少一条乙烯基聚合物链和至少一条聚氨酯聚合物链，其中乙烯基聚合物链通过具有硅氧键的连接段与聚氨酯聚合物链结合。 一种生产乙烯基-聚氨酯共聚物的方法，该共聚物包括至少一条乙烯基聚合物链和至少一条聚氨酯聚合物链，其中乙烯基聚合物链通过具有硅氧键的连接段与聚氨酯聚合物链结合，具体方法如下： 步骤(X)和步骤(Y)：步骤(X)：制备具有至少一个含硅可水解基团的聚氨酯聚合物(A)的水分散液或水溶液；步骤(Y)，在具有至少一个含硅可水解基团的聚氨酯聚合物 (A) 的水分散体或水溶液中在聚合反应前、聚合反应中和聚合反应后的至少一个选自聚合反应前、聚合反应中和聚合反应后的时期内，使用具有至少一个与含硅可水解基团反应的官能团和至少一个与含乙烯基不饱和键基团反应的官能团的化合物 (C) 进行乙烯基不饱和单体 (B) 的聚合，并制备乙烯基聚氨酯共聚物。
• POWELL, J.;JAMES, N.;SMITH, S. J., SYNTHESIS, BRD, 1986, N 4, 338-340
  作者：POWELL, J.、JAMES, N.、SMITH, S. J.

  DOI：——

  日期：——
• Vinyl-urethane copolymers and production methods thereof
  申请人：Origuchi Toshiki

  公开号：US20070117902A1

  公开（公告）日：2007-05-24

  To provide vinyl-urethane copolymers that can form cured articles having excellent hot-water resistance, water resistance, heat resistance, and weather resistance, and to provide production methods thereof. A vinyl-urethane copolymer contains at least one vinyl polymer chain and at least one urethane polymer chain, in which the vinyl polymer chain is combined with the urethane polymer chain through a linkage segment having a silicon-oxygen bond. A method produces a vinyl-urethane copolymer comprising at least one vinyl polymer chain and at least one urethane polymer chain, in which the vinyl polymer chain is combined with the urethane polymer chain through a linkage segment having a silicon-oxygen bond, by following Steps (X) and (Y): Step (X) of carrying out preparation of an aqueous dispersion or aqueous solution of a urethane polymer (A) having at least one silicon-containing hydrolyzable group; and Step (Y) of, in the aqueous dispersion or aqueous solution of the urethane polymer (A) having at least one silicon-containing hydrolyzable group, carrying out polymerization of an ethylenically unsaturated monomer (B) and carrying out preparation of a vinyl-urethane copolymer using a compound (C) having at least one functional group reactive with a silicon-containing hydrolyzable group and at least one functional group reactive with an ethylenically unsaturated bond-containing group in at least one period selected from before the polymerization reaction, during the polymerization reaction, and after the polymerization reaction.
• NITROGEN OXIDE-DONATING PDE-5 AND/OR PDE-6 INHIBITOR COMPOUNDS, AND USES THEREOF
  申请人：ILDONG PHARMACEUTICAL CO., LTD.

  公开号：US20220153746A1

  公开（公告）日：2022-05-19

  The present disclosure provides uses of phosphodiesterase 5 (PDE-5) and/or phosphodiesterase 6 (PDE-6) inhibitor compounds and uses of compositions including said compounds. In some embodiments, said compounds are nitrogen oxide (NO) donating PDE-5 and/or -6 inhibitor compounds that include a nitrogen oxide-containing donor substituent attached to a benzenesulfonamide group. The compounds can provide dual functionality for increasing protein kinase G (PKG) activity by inhibiting PDE-5 and PDE-6, and/or stimulating guanylate cyclase via donation of NO from the donor substituent of the compound. The present disclosure also provides methods of using said compounds and compositions for inhibiting PDE-5 and/or -6 and increasing activity of PKG. The compounds and compositions find use in the treatment of a variety of eye diseases. For example, the subject compounds may be used as a therapeutic agent for glaucoma, age-related macular degeneration, diabetic retinopathy, xerophthalmia, dry eye syndrome, cataracts or uveitis.