N-去甲基羧基特比萘芬盐酸盐 | 99473-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-去甲基羧基特比萘芬盐酸盐
• 中文别名: 特比萘芬杂质5
• 英文名称: (E)-2,2-dimethyl-7-(naphthalen-1-ylmethylazaniumyl)hept-5-en-3-ynoate
• CAS: 99473-15-1
• 化学式: C20H21NO2
• 分子量: 307.4
• InChiKey: HLMXKUJHRUTHIL-XVNBXDOJSA-N

物化性质

• 熔点：
  158-160°C (dec.)
• 溶解度：
  DMF、DMSO、乙醇、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Specific monoclonal antibody against terbinafine
  申请人：——

  公开号：US20030087323A1

  公开（公告）日：2003-05-08

  The invention concerns monoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immunogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.

  本发明涉及到针对自由基或盐形式的特比林的单克隆抗体，适用于制备免疫原偶联物的免疫原偶联物，能够产生它们的杂交瘤，以及相应的测定试剂盒。这些抗体可以通过向适当的动物施加适当的特比林衍生物与免疫原共价结合的免疫原偶联物来制备，从感受到偶联物的抗体产生细胞中恢复，使抗体产生细胞不死化，选择所得到的不死化细胞系，并从中恢复所得到的抗体。它们适用于特别用于测量特比林在生理液或组织中的浓度和分布，尤其是指甲。
• SPECIFIC MONOCLONAL ANTIBODY AGAINST TERBINAFINE
  申请人：Novartis AG

  公开号：EP1261874B1

  公开（公告）日：2010-05-26
• US7122184B2
  申请人：——

  公开号：US7122184B2

  公开（公告）日：2006-10-17
• [EN] SPECIFIC MONOCLONAL ANTIBODY AGAINST TERBINAFINE<br/>[FR] ANTICORPS MONOCLONAL SPECIFIQUE UTILISE POUR LUTTER CONTRE LA TERBINAFINE
  申请人：NOVARTIS AG

  公开号：WO2001059458A1

  公开（公告）日：2001-08-16

  The invention concerns monoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immunogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.