2-Octylamino-4-octadecen-1,3-diol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Octylamino-4-octadecen-1,3-diol
• 英文别名: (E)-2-(octylamino)octadec-4-ene-1,3-diol
• 化学式: C₂₆H₅₃NO₂
• 分子量: 411.7
• InChiKey: CSRGRGSMEUKQSD-LSDHQDQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  29
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Ceramide and chemotherapeutic agents for inducing cell death
  申请人：Roger Williams Hospital

  公开号：EP2020237A2

  公开（公告）日：2009-02-04

  This invention provides a method for increasing apoptosis in tumor cells and a method of decreasing a size of a tumor, said methods comprising contacting the tumor cells with: a) an effective amount of at least one antitumor chemotherapeutic agent; and b) an effective amount of a ceramide, sequentially or concomitantly, wherein the apoptosis induced by the combination of the antitumor chemotherapeutic agent and the ceramide is greater than the apoptosis induced by contact of the tumor cells with either the antitumor chemotherapeutic agent alone or the ceramide alone. This invention also provides a method of treating cancer in a subject which comprises a method according to either of the above-described methods. This invention provides a method for treating cancer in a subject comprising administering to the subject an effective amount of at least one antitumor chemotherapeutic agent and an effective amount of at least one ceramide, sequentially or concomitantly. This invention provides a pharmaceutical composition comprising at least one antitumor chemotherapeutic agent in an amount effective to induce apoptosis of tumor cells and at least one ceramide in an amount effective to induce apoptosis of tumor cells and a pharmaceutically acceptable carrier.

  本发明提供了一种增加肿瘤细胞凋亡的方法和一种减小肿瘤体积的方法，所述方法包括使肿瘤细胞与以下物质接触：a) 有效量的至少一种抗肿瘤化疗剂；和 b) 有效量的神经酰胺，依次或同时进行，其中抗肿瘤化疗剂和神经酰胺的组合诱导的凋亡大于肿瘤细胞单独接触抗肿瘤化疗剂或单独接触神经酰胺诱导的凋亡。本发明还提供了一种治疗受试者癌症的方法，该方法包括根据上述任一方法的方法。本发明提供了一种治疗受试者癌症的方法，该方法包括依次或同时向受试者施用有效量的至少一种抗肿瘤化疗剂和有效量的至少一种神经酰胺。本发明提供了一种药物组合物，该组合物包含至少一种抗肿瘤化疗剂（其有效量可诱导肿瘤细胞凋亡）和至少一种神经酰胺（其有效量可诱导肿瘤细胞凋亡）以及一种药学上可接受的载体。
• CERAMIDE AND CHEMOTHERAPEUTIC AGENTS FOR INDUCING CELL DEATH
  申请人：Roger Williams Hospital

  公开号：EP1206270A1

  公开（公告）日：2002-05-22
• EP1206270A4
  申请人：——

  公开号：EP1206270A4

  公开（公告）日：2004-04-07
• COMBINATION OF CERAMIDE AND OXALIPLATIN FOR INDUCING CELL DEATH AND USES THEREOF IN TREATING CANCER
  申请人：Roger Williams Hospital

  公开号：EP2038248A2

  公开（公告）日：2009-03-25
• Combination of ceramide and oxaliplatin for inducing cell death and uses thereof in treating cancer
  申请人：Wanebo J. Harold

  公开号：US20080033039A1

  公开（公告）日：2008-02-07

  This invention provides a method for increasing apoptosis in a cancer cell comprising contacting the cancer cell with (a) oxaliplatin and (b) C6-ceramide, sequentially or concomitantly, wherein the oxaliplatin and C6-ceramide are in amounts such that the apoptosis induced by the combination of oxaliplatin and C6-ceramide is greater than the apoptosis induced by contacting the cancer cell with either oxaliplatin alone or C6-ceramide alone. This invention also provides a method of decreasing the size of a tumor, which method comprises contacting the tumor with (a) oxaliplatin and (b) C6-ceramide, sequentially or concomitantly, wherein the oxaliplatin and C6-ceramide are in amounts such that the decrease in tumor size induced by the combination of oxaliplatin and C6-ceramide is greater than the decrease in tumor size induced by contacting the tumor with either oxaliplatin alone or C6-ceramide alone. This invention further provides a pharmaceutical composition and a method for treating a subject afflicted with cancer.