2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxypyran-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxypyran-4-one
• 化学式: C₁₃H₁₀O₅
• 分子量: 246.21
• InChiKey: QISBNGLMCHHHFG-HNQUOIGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• DNA CYTOSINE DEAMINASE INHIBITORS
  申请人：Harris Reuben S.

  公开号：US20110218158A1

  公开（公告）日：2011-09-08

  Cytosine deaminase inhibitors and methods for identifying inhibitors of the anti-retroviral activity of APOBEC3G are described.
• US20140275224A1
  申请人：——

  公开号：US20140275224A1

  公开（公告）日：2014-09-18
• AGONISTS OF THE AhR RECEPTOR PATHWAY HAVING SEBOSUPPRESSIVE ACTIVITY AND A METHOD FOR IDENTIFYING SAID AGONISTS
  申请人：SAURAT Jean Hilaire

  公开号：US20150057343A1

  公开（公告）日：2015-02-26

  The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-1-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway, useful in such methods and compositions.
• METHOD AND COMPOSITION FOR TREATING ACNE
  申请人：Saurat Jean Hilaire

  公开号：US20170042856A1

  公开（公告）日：2017-02-16

  The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway useful in such methods and compositions.
• US9480674B2
  申请人：——

  公开号：US9480674B2

  公开（公告）日：2016-11-01