1-(1,3-benzothiazol-2-yl)-2-(4-methoxybenzylidene)hydrazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1-(1,3-benzothiazol-2-yl)-2-(4-methoxybenzylidene)hydrazine
• 英文别名: N-[(Z)-(4-methoxyphenyl)methylideneamino]-1,3-benzothiazol-2-amine
• 化学式: C₁₅H₁₃N₃OS
• 分子量: 283.354
• InChiKey: UYABVUDGGULXKZ-YBEGLDIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,3,4,5-tetrafluorobenzoyl isothiocyanate 、 1-(1,3-benzothiazol-2-yl)-2-(4-methoxybenzylidene)hydrazine 以 乙腈 为溶剂， 以82%的产率得到N-(1,3-benzothiazol-2-yl)-2,3,4,5-tetrafluoro-N'-(4-methoxybenzylidene)benzohydrazide
  参考文献：
  名称：

  Fluorine-containing heterocycles: XVI. Reactions of tetrafluorobenzoyl isothiocyanate with hydrazines and their derivatives

  摘要：

  Fluorinated derivatives of 4H-1,3-benzothiazin-4-one, [1,2,4]triazolo[4,3-a]pyrimidine, [1,2,4]triazolo[3,4-b][1,3]benzazoles, and 1,5-dihydro-1,2,4-triazole-5-thione were synthesized by addition of hydrazines and their derivatives to tetrafluorobenzoyl isothiocyanate, followed by cyclization of intermediate thiosemicarbazides.

  DOI：

  10.1134/s1070428007010083

文献信息

• Fluorine-containing heterocycles: XVI. Reactions of tetrafluorobenzoyl isothiocyanate with hydrazines and their derivatives
  作者：E. V. Nosovoa、G. N. Lipunova、A. A. Laeva、L. P. Sidorova、V. N. Charushin

  DOI：10.1134/s1070428007010083

  日期：2007.1

  Fluorinated derivatives of 4H-1,3-benzothiazin-4-one, [1,2,4]triazolo[4,3-a]pyrimidine, [1,2,4]triazolo[3,4-b][1,3]benzazoles, and 1,5-dihydro-1,2,4-triazole-5-thione were synthesized by addition of hydrazines and their derivatives to tetrafluorobenzoyl isothiocyanate, followed by cyclization of intermediate thiosemicarbazides.