C-(3,3-Dimethyl-cyclohexyl)-methylamine | 381665-68-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: C-(3,3-Dimethyl-cyclohexyl)-methylamine
• 英文别名: (3,3-Dimethylcyclohexyl)methanamine
• CAS: 381665-68-5
• 化学式: C₉H₁₉N
• 分子量: 141.257
• InChiKey: LWKSMALURDOKBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  C-(3,3-Dimethyl-cyclohexyl)-methylamine 、 4-已氧基苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-[(3,3-Dimethylcyclohexyl)Methyl]-4-(Hexyloxy)Benzamide
  参考文献：
  名称：

  Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable I_Ks Blockers

  摘要：

  Multiple delayed rectifier potassium currents, including I-Ks are responsible for the repolarization and termination of the cardiac action potential, and blockers of these currents may be useful as antiarrhythmic agents. Modification of compound 5 produced 19(S) that is the most potent IF, blocker reported to date with > 5000-fold selectivity over other cardiac ion channels. Further modification produced 24A with 23% oral bioavailability.

  DOI：

  10.1021/jm015505u

文献信息

• COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA
  申请人：Chen Li

  公开号：US20110195979A1

  公开（公告）日：2011-08-11

  A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R 1 to R 4 and Ar are as defined in description and in claims, can be used as a medicament.

  化合物的化学式（I）及其药用盐，其中R1至R4和Ar如描述和权利要求中所定义，可用作药物。
• [EN] PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS<br/>[FR] DÉRIVÉS PYRROLIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA VOIE DU COMPLÉMENT
  申请人：NOVARTIS AG

  公开号：WO2014002054A1

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种化合物(I)的方法，用于制造该发明的化合物，并将其用作眼部疾病治疗的补体途径调节剂。本发明还提供了一种药理活性剂的组合和制药组合物。
• [EN] COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA<br/>[FR] COMPOSÉS POUR LE TRAITEMENT ET LA PRÉVENTION DE LA GRIPPE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011095576A1

  公开（公告）日：2011-08-11

  A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.

  式（I）的化合物及其药学上可接受的盐，其中R1至R4和Ar如描述和索赔中定义的，可用作药物。
• METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS
  申请人：IGNAR DIANE MICHELE

  公开号：US20100113512A1

  公开（公告）日：2010-05-06

  A method of treatment using pharmaceutical compositions containing novel antagonists or inverse agonists at opioid receptors for the treatment of binge eating disorder, anorexia nervosa, bulimia nervosa, excess drug or alcohol use, or eating disorder not otherwise specified.

  使用含有新型阿片受体拮抗剂或反向激动剂的药物组合物治疗暴食症、厌食症、暴食症、过度药物或酒精使用或其他未明确指定的进食障碍的治疗方法。
• NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS
  申请人：Cowan David John

  公开号：US20110124559A1

  公开（公告）日：2011-05-26

  Novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, pharmaceutical compositions containing them, to processes for their preparation.

  小说化合物，它们是阿片受体的拮抗剂或逆向激动剂，含有它们的药物组合物，以及它们的制备方法。