N-(2-pyrazinyl)-2-(2-hydroxynaphthalen-1-yl)glycine | 1260490-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-pyrazinyl)-2-(2-hydroxynaphthalen-1-yl)glycine
• 英文别名: 2-(2-Hydroxynaphthalen-1-yl)-2-(pyrazin-2-ylamino)acetic acid
• CAS: 1260490-15-0
• 化学式: C₁₆H₁₃N₃O₃
• 分子量: 295.298
• InChiKey: WUZNATKEGJSJGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  95.3
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  氨基吡嗪 、 乙醛酸 、 2-萘酚 以 水 为溶剂， 反应 4.0h， 以75%的产率得到N-(2-pyrazinyl)-2-(2-hydroxynaphthalen-1-yl)glycine
  参考文献：
  名称：

  One-Pot, Three-Component Coupling Reaction: Catalyst-Free Green Synthesis of NovelN-Heteroaryl α-Naphthylglycines

  摘要：

  A series of novel N-heteroaryl -arylglycines containing naphthol rings has been prepared by one-pot, three-component condensation reaction of glyoxalic acid, heteroaryl amines and naphthols in water at ambient temperature and under reflux conditions in moderate to high yields. The promising advantages such as removal of organic solvent, no need to catalyst, simplicity of the reaction procedure and easy product separation will be discussed in this article.

  DOI：

  10.1080/00397910903457407

文献信息

• One-Pot, Three-Component Coupling Reaction: Catalyst-Free Green Synthesis of Novel<i>N</i>-Heteroaryl α-Naphthylglycines
  作者：Abolfazl Olyaei、Esmat Chehrehgosha Parashkuhi、Saeed Raoufmoghaddam、Mahdieh Sadeghpour

  DOI：10.1080/00397910903457407

  日期：2010.11.16

  A series of novel N-heteroaryl -arylglycines containing naphthol rings has been prepared by one-pot, three-component condensation reaction of glyoxalic acid, heteroaryl amines and naphthols in water at ambient temperature and under reflux conditions in moderate to high yields. The promising advantages such as removal of organic solvent, no need to catalyst, simplicity of the reaction procedure and easy product separation will be discussed in this article.