4-methoxy-N-[(E)-(3,3,6,8-tetramethyl-1-oxo-4H-naphthalen-2-ylidene)amino]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-methoxy-N-[(E)-(3,3,6,8-tetramethyl-1-oxo-4H-naphthalen-2-ylidene)amino]benzamide
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.4
• InChiKey: JLXKWJGTZIPHBG-ATJXCDBQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  67.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• GAIN-OF-FUNCTION BCL-2 INHIBITORS
  申请人：HOCKENBERY David

  公开号：US20120252839A1

  公开（公告）日：2012-10-04

  Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Several scaffolds of active compounds are described.
• US8865901B2
  申请人：——

  公开号：US8865901B2

  公开（公告）日：2014-10-21
• [EN] COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE MODULATION DE L'APOPTOSE DANS DES CELLULES SUREXPRIMANT LES PROTÉINES MEMBRES DE LA FAMILLE BCL-2
  申请人：HUTCHINSON FRED CANCER RES

  公开号：WO2008021211A2

  公开（公告）日：2008-02-21

  [EN] The present invention relates to compounds for modulating apoptosis in cells over expressing Bcl-2 Family member proteins (e.g., Bcl-2 or Bcl-x_L). The present invention also relates to pharmaceutical compositions containing these compounds, and methods of using the compounds for treating apoptosis-associated diseases such as, for example, neoplastic disease (e.g., cancer) or other proliferative diseases associated with the over-expression of a Bcl-2 family member protein.
  [FR] La présente invention concerne des composés permettant de moduler l'apoptose dans des cellules surexprimant des protéines membres de la famille Bcl-2 (notamment Bcl-2 ou Bcl-xL). La présente invention concerne également des compositions pharmaceutiques contenant ces composés, et des procédés d'utilisation des composés pour traiter des maladies associées à l'apoptose telles que, par exemple, une maladie néoplasique (notamment le cancer) ou d'autres maladies prolifératives associées à la surexpression d'une protéine membre de la famille Bcl-2.