1,3-Dinitro-1,2-diphenyl-propan | 55109-46-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,3-Dinitro-1,2-diphenyl-propan
• 英文别名: 1,3-dinitro-1,2-diphenyl-propane；(1,3-Dinitro-1-phenylpropan-2-yl)benzene
• CAS: 55109-46-1
• 化学式: C₁₅H₁₄N₂O₄
• 分子量: 286.287
• InChiKey: XTAICHDILDNLBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  硝基甲苯 、 β-硝基苯乙烯 在 二乙胺 、 Petroleum ether 作用下， 生成 1,3-Dinitro-1,2-diphenyl-propan
  参考文献：
  名称：

  Retinal blood flow and systemic blood pressure in healthy young subjects

  摘要：

  Background: The aim of the present study was to investigate the association between systemic blood pressure and retinal blood flow in healthy young subjects. Methods: Three independent study cohorts were included. A cross-sectional study was performed in 420 young male subjects with systolic blood pressure less than or equal to 160 mmHg and diastolic blood pressure less than or equal to 100 mmHg. Retinal white blood cell flux (n=210) and blood velocity in the central retinal artery (n=210) were measured. In addition, a longitudinal study was performed in 40 young male subjects in whom retinal and systemic haemodynamic parameters were measured thrice within 6 weeks. Retinal white blood cell flux was measured with the blue-field entoptic technique. Blood flow velocity in the central retinal artery was measured by means of colour Doppler imaging. Results: Retinal white blood cell flux (r=0.262; P <0.001) and mean flow velocity in the central retinal artery (r=0.174, P=0.010) were significantly associated with mean arterial pressure in the cross-sectional study. In the longitudinal study retinal white blood cell flux and mean flow velocity in the central retinal artery were also correlated with systemic blood pressure. Conclusions: Our data indicate a slight but significant increase in retinal blood flow with blood pressure. Whether this is of clinical relevance in eye diseases with altered retinal perfusion, such as diabetic retinopathy, remains to be established.

  DOI：

  10.1007/s004170100333

文献信息

• The inverted ketene synthon: a double umpolung approach to enantioselective β^2,3-amino amide synthesis
  作者：Mahesh Vishe、Jeffrey N. Johnston

  DOI：10.1039/c8sc04330b

  日期：——

  A stereocontrolled synthesis of β2,3-amino amides is reported. Innovation is encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β-amino amide synthesis. Step economy is also fulfilled by the use of Umpolung Amide Synthesis (UmAS) in the second step, delivering the amide product without intermediacy of a carboxylic acid or activated derivative. Molybdenum oxide-mediated

  报道了β 2,3 -氨基酰胺的立体控制合成。创新体现在首次使用硝基烯烃在对映选择性 β-氨基酰胺合成中实现双极化。第二步中使用 Umpolung 酰胺合成 (UmAS) 也实现了步骤经济性，无需中间羧酸或活化衍生物即可生成酰胺产物。氧化钼介导的氢化物还原提供了具有高选择性的抗-β 2,3-氨基酰胺。
• Fluoride Ion as a Catalyst for Michael Additions to Nitro-Alkenes
  作者：Shmaryahu HOZ、Michael ALBECK、Zvi RAPPOPORT

  DOI：10.1055/s-1975-23689

  日期：——
• Retinal blood flow and systemic blood pressure in healthy young subjects
  作者：Gabriele Fuchsjäger-Mayrl、Kaija Polak、Alexandra Luksch、Elzbieta Polska、Guido T. Dorner、Georg Rainer、Hans-Georg Eichler、Leopold Schmetterer

  DOI：10.1007/s004170100333

  日期：2001.9

  Background: The aim of the present study was to investigate the association between systemic blood pressure and retinal blood flow in healthy young subjects. Methods: Three independent study cohorts were included. A cross-sectional study was performed in 420 young male subjects with systolic blood pressure less than or equal to 160 mmHg and diastolic blood pressure less than or equal to 100 mmHg. Retinal white blood cell flux (n=210) and blood velocity in the central retinal artery (n=210) were measured. In addition, a longitudinal study was performed in 40 young male subjects in whom retinal and systemic haemodynamic parameters were measured thrice within 6 weeks. Retinal white blood cell flux was measured with the blue-field entoptic technique. Blood flow velocity in the central retinal artery was measured by means of colour Doppler imaging. Results: Retinal white blood cell flux (r=0.262; P <0.001) and mean flow velocity in the central retinal artery (r=0.174, P=0.010) were significantly associated with mean arterial pressure in the cross-sectional study. In the longitudinal study retinal white blood cell flux and mean flow velocity in the central retinal artery were also correlated with systemic blood pressure. Conclusions: Our data indicate a slight but significant increase in retinal blood flow with blood pressure. Whether this is of clinical relevance in eye diseases with altered retinal perfusion, such as diabetic retinopathy, remains to be established.