4-(2,4,7-triamino-5H-pteridin-6-ylidene)cyclohexa-2,5-dien-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 4-(2,4,7-triamino-5H-pteridin-6-ylidene)cyclohexa-2,5-dien-1-one
• 化学式: C₁₂H₁₁N₇O
• 分子量: 269.26
• InChiKey: FVVQYJRJSSHFNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Therapeutic approaches for treating parkinson's disease
  申请人：Pharnext

  公开号：EP2705842A1

  公开（公告）日：2014-03-12

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

  本发明涉及治疗帕金森病及相关疾病的组合物和方法。更具体地说，本发明涉及针对α-突触核蛋白聚集网络的帕金森病及相关疾病的新型组合疗法。特别是，本发明涉及可单独或以组合形式有效保护神经元细胞免受α-突触核蛋白聚集的化合物。本发明还涉及生产治疗帕金森病的药物或药物组合的方法，以及治疗帕金森病或相关疾病的方法。
• Therapeutic approaches for treating Parkinson's disease
  申请人：Pharnext

  公开号：US10004744B2

  公开（公告）日：2018-06-26

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.

  本发明涉及治疗帕金森病及相关疾病的组合物和方法。更具体地说，本发明涉及针对α-突触核蛋白聚集网络的帕金森病及相关疾病的新型组合疗法。特别是，本发明涉及可单独或以组合形式有效保护神经元细胞免受α-突触核蛋白聚集的化合物。本发明还涉及生产治疗帕金森病的药物或药物组合的方法，以及治疗帕金森病或相关疾病的方法。
• COMPOSITIONS FOR TREATING PARKINSON'S DISEASE
  申请人：Pharnext

  公开号：EP2892518B1

  公开（公告）日：2018-07-11
• NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE
  申请人：Pharnext

  公开号：US20150246044A1

  公开（公告）日：2015-09-03

  The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
• COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES
  申请人：Pharnext

  公开号：US20170049777A1

  公开（公告）日：2017-02-23

  The present invention relates to compositions and methods for the treatment of diabetic neuropathies. More particularly, this invention relates to compositions and methods for promoting nerve regeneration in a subject suffering from, or at risk of suffering from a diabetic neuropathy, and for protecting nervous system cells against the stresses resulting from the perturbation of glucose homeostasis. More specifically, the present invention relates to novel single or combination therapies for diabetic neuropathies, comprising diabetic peripheral neuropathy, diabetic proximal neuropathy, diabetic autonomic neuropathy and diabetic focal neuropathy, based on restoring dorsal root ganglion neurons and other nerves integrity.