磺胺类药物在20世纪30年代迅速发展,临床应用的种类曾多达20余种。然而,40年代以后随着青霉素等抗生素的出现,其在化学治疗中的地位有所下降。尽管如此,磺胺类药物仍因其广谱抗菌、疗效确切、可口服且吸收较快等特点而备受青睐。与甲氧苄啶(Trimethoprim)合用时,其抗菌作用会显著增强,仍然是较为常用的抗菌药物之一。
磺胺类药物的作用机制得以阐明后,确立了抗代谢学说,为新药的研发开辟了一条新的途径。目前临床上使用较多的磺胺类药物包括磺胺嘧啶(Sulfadiazine)和磺胺甲噁唑(Sulfamethoxazole)。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| 2-溴-N-(呋喃-2-基甲基)苯磺酰胺 | 2-bromo-N-(furan-2-ylmethyl)benzenesulfonamide | 849056-66-2 | C11H10BrNO3S |
| 2-溴-N-(3-甲氧基丙基)苯磺酰胺 | 2-bromo-N-(3-methoxypropyl)benzenesulfonamide | 848906-56-9 | C10H14BrNO3S |
| 2-溴-N-(2,4-二甲基苯基)苯磺酰胺 | 2-bromo-N-(2,4-dimethylphenyl)benzenesulfonamide | 941294-29-7 | C14H14BrNO2S |
| 2-溴-N-(2,4-二氟苯基)苯磺酰胺 | 2-bromo-N-(2,4-difluorophenyl)benzenesulfonamide | 941294-30-0 | C12H8BrF2NO2S |
| 2-溴-N-(2,3-二甲基苯基)苯磺酰胺 | 2-bromo-N-(2,3-dimethylphenyl)benzenesulfonamide | 941294-37-7 | C14H14BrNO2S |
| 2-溴-N,N-二乙基苯磺酰胺 | 2-bromo-N,N-diethylbenzenesulfonamide | 65000-12-6 | C10H14BrNO2S |
| 2-溴-N,N-二丙基苯磺酰胺 | 2-bromo-N,N-dipropylbenzenesulfonamide | 65000-11-5 | C12H18BrNO2S |
| 2-吗啉磺酰基苯硼酸 | 2-(morpholin-4-ylsulphonyl)phenylboronic acid | 957062-65-6 | C10H14BNO5S |
| 2-N.N-二乙基磺酰胺苯硼酸 | (2-(N,N-diethylsulfamoyl)phenyl)boronic acid | 957061-16-4 | C10H16BNO4S |
| 2-(哌啶-1-基磺酰基)苯硼酸 | 2-(Piperidin-1-ylsulfonyl)phenylboronic acid | 957034-87-6 | C11H16BNO4S |
| 2-(二甲基氨基磺酰基)苯硼酸 | (2-(N,N-dimethylsulfamoyl)phenyl)boronic acid | 178432-25-2 | C8H12BNO4S |
| 2-(4-溴苯基磺酰氨基)乙酸 | [(4-bromophenyl)sulfonylamino]acetic acid | 13029-73-7 | C8H8BrNO4S |
| 1-(5-溴-2-甲氧基苯基磺酰)哌啶 | 1-((5-Bromo-2-methoxyphenyl)sulfonyl)piperidine | 295360-83-7 | C12H16BrNO3S |
| 1-(5-溴-2-甲氧基苯基磺酰)吡咯啉 | 1-(5-Bromo-2-methoxyphenylsulfonyl)pyrrolidine | 691381-10-9 | C11H14BrNO3S |
| 1-(4-溴苯基磺酰)哌啶-4-酮 | 1-(4-bromophenylsulfonyl)piperidin-4-one | 929000-54-4 | C11H12BrNO3S |
| 1-(4-溴苯基磺酰)哌啶 | 1-((4-bromophenyl)sulfonyl)piperidine | 834-66-2 | C11H14BrNO2S |
| 1-(4-溴苯基磺酰)吡咯啉 | 1-((4-bromophenyl)sulfonyl)pyrrolidine | 136350-52-2 | C10H12BrNO2S |
| 1-(4-溴苯基磺酰)吖丁啶 | 1-((4-bromophenyl)sulfonyl)azetidine | 530081-57-3 | C9H10BrNO2S |
| 1-(4-氟苯基磺酰)吡咯啉 | 1-((4-fluorophenyl)sulfonyl)pyrrolidine | 157187-14-9 | C10H12FNO2S |
| 1-(3-硝基苯基磺酰基)哌啶 | 1-((3-nitrophenyl)sulfonyl)piperidine | 91619-31-7 | C11H14N2O4S |
| 1-(3-硝基苯基磺酰)吡咯啉 | 1-(3-nitrophenylsulfonyl)pyrrolidine | 91619-30-6 | C10H12N2O4S |
| 1-(3-溴苯基磺酰)哌啶 | 1-((3-bromophenyl)sulfonyl)piperidine | 871269-12-4 | C11H14BrNO2S |
| 1-(3-溴苯基磺酰)吡咯啉 | 1-((3-bromophenyl)sulfonyl)pyrrolidine | 214210-14-7 | C10H12BrNO2S |
| 1-(3-溴-4-甲基苯基磺酰)哌啶 | 1-(3-Bromo-4-methylphenylsulfonyl)piperidine | 850429-73-1 | C12H16BrNO2S |
| 1-(3-溴-4-甲基苯基磺酰)吡咯啉 | 1-(3-Bromo-4-methylphenylsulfonyl)pyrrolidine | 850429-75-3 | C11H14BrNO2S |
| 1-(3-溴-4-甲基苯基磺酰)吗啉 | 4-((3-Bromo-4-methylphenyl)sulfonyl)morpholine | 850429-74-2 | C11H14BrNO3S |
| 1-(2-溴苯基磺酰)吡咯啉 | 1-((2-bromophenyl)sulfonyl)pyrrolidine | 929000-58-8 | C10H12BrNO2S |
| 1,4-丁烷磺内酰胺 | 1,4-butanesultam | 37441-50-2 | C4H9NO2S |
| (4-甲烷磺酰氨甲基)苯基硼酸 | (4-methanesulfonylaminomethylphenyl)boronic acid | 850568-38-6 | C8H12BNO4S |
| (3-甲烷磺酰氨甲基)苯基硼酸 | [3-(methanesulfonamidomethyl)phenyl]boronic acid | 850568-39-7 | C8H12BNO4S |
| —— | Silvadene | 1152234-18-8 | C10H10AgN4O2S |
| —— | sodium sulfamerazine | 127-58-2 | C11H11N4O2S*Na |
| —— | [4-methoxy-3-(morpholin-4-ylsulphonyl)phenyl]boronic acid | 871333-02-7 | C11H16BNO6S |
| —— | sulfadimethoxine sodium | 1037-50-9 | C12H13N4O4S*Na |
| —— | 3-(4-Sulfamoylphenyl)propanoate | 90610-69-8 | C9H10NO4S- |
| —— | sodium;4-amino-N-quinoxalin-2-ylbenzenesulfonamide | 59-40-5 | C14H12N4NaO2S+ |
| —— | Solumedine | 127-58-2 | C11H12N4NaO2S+ |
| —— | prontosil | 103-12-8 | C12H13N5O2S |
| —— | sulfamethoxazole (SMZ) sodium salt | 4563-84-2 | C10H10N3O3S*Na |
| —— | sulphamethoxazole sodium salt | 4563-84-2 | C10H10N3O3S*Na |
| —— | sodium sulfamethazine | 1981-58-4 | C12H13N4O2S*Na |
| —— | sodium sulfadiazine | 547-32-0 | C10H9N4O2S*Na |
| —— | mafenide hydrochloride | 49783-80-4 | C7H10N2O2S*ClH |
| —— | trimethoprim | 738-70-5 | C14H17N3O3 |
| —— | sulfacetamide sodium | 127-56-0 | C8H9N2O3S*Na |
| —— | sulfathiazole sodium | 144-74-1 | C9H8N3O2S2*Na |
| —— | sulfasalazine | 599-79-1 | C18H14N4O5S |