磺胺类药及增效剂
磺胺类药物在20世纪30年代迅速发展，临床应用的种类曾多达20余种。然而，40年代以后随着青霉素等抗生素的出现，其在化学治疗中的地位有所下降。尽管如此，磺胺类药物仍因其广谱抗菌、疗效确切、可口服且吸收较快等特点而备受青睐。与甲氧苄啶（Trimethoprim）合用时，其抗菌作用会显著增强，仍然是较为常用的抗菌药物之一。
磺胺类药物的作用机制得以阐明后，确立了抗代谢学说，为新药的研发开辟了一条新的途径。目前临床上使用较多的磺胺类药物包括磺胺嘧啶（Sulfadiazine）和磺胺甲噁唑（Sulfamethoxazole）。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| N-(2-boc-氨基乙基)-4-溴苯磺酰胺 | tert-butyl (2-((4-bromophenyl)sulfonamido)ethyl)carbamate | 310480-85-4 | C13H19BrN2O4S |
|
| N,N-二甲基砒啶-3-磺酰胺 | N,N-Dimethyl-3-pyridinsulfonsaeureamid | 4810-41-7 | C7H10N2O2S |
|
| N,N-二甲基咪唑-1-磺酰胺 | N,N-dimethyl-1H-imidazole-1-sulfonamide | 78162-58-0 | C5H9N3O2S |
|
| N,N-二甲基-4-碘-1H-咪唑-1-磺酰胺 | 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide | 135773-25-0 | C5H8IN3O2S |
|
| N,N-二甲基-4-硼苯磺酰胺 | {4-[(dimethylamino)sulfonyl]phenyl}boronic acid | 486422-59-7 | C8H12BNO4S |
|
| N,N-二甲基-4,5-二碘-1H-咪唑-1-磺酰胺 | 4,5-diiodo-1-(N,N-dimethylsulfamoyl)-1H-imidazole | 198127-92-3 | C5H7I2N3O2S |
|
| N,N-二甲基-3-硼苯磺酰胺 | (3-(N,N-dimethylsulfamoyl)phenyl)boronic acid | 871329-59-8 | C8H12BNO4S |
|
| N,N-二甲基-3-硼-4-甲基苯磺酰胺 | [5-(dimethylsulphamoyl)-2-methylphenyl]boronic acid | 871332-99-9 | C9H14BNO4S |
|
| N,N-二甲基-3-硝基苯磺酰胺 | N,N-dimethyl-3-nitro-benzenesulfonamide | 26199-83-7 | C8H10N2O4S |
|
| N,N-二甲基-3-溴苯磺酰胺 | 3-bromo-N,N-dimethylbenzenesulfonamide | 153435-80-4 | C8H10BrNO2S |
|
| N,N-二甲基-3-溴-4-甲基苯磺酰胺 | N,N-dimethyl-3-bromo-4-methylbenzenesulfonamide | 850429-72-0 | C9H12BrNO2S |
|
| N,N-二甲基-2-溴苯磺酰胺 | 2-bromo-N,N-dimethylbenzenesulfonamide | 65000-13-7 | C8H10BrNO2S |
|
| N,N-二乙基3-溴-4-甲基苯磺酰胺 | N,N-Diethyl 3-bromo-4-methylbenzenesulfonamide | 850429-71-9 | C11H16BrNO2S |
|
| N,N-二乙基-5-硼-2-甲氧基苯磺酰胺 | (3-(N,N-Diethylsulfamoyl)-4-methoxyphenyl)boronic acid | 871333-03-8 | C11H18BNO5S |
|
| N,N-二乙基-5-溴-2-甲氧基苯磺酰胺 | 5-bromo-N,N-diethyl-2-methoxybenzenesulfonamide | 428471-30-1 | C11H16BrNO3S |
|
| N,N-二乙基-4-硼苯磺酰胺 | 4-diethylsulfamoylphenylboronic acid | 850568-76-2 | C10H16BNO4S |
|
| N,N-二乙基-4-溴苯磺酰胺 | 4-bromo-N,N-diethylbenzenesulfonamide | 90944-62-0 | C10H14BrNO2S |
|
| N,N-二乙基-3-硼苯磺酰胺 | 3-(diethylsulfamoyl)phenyl boronic acid | 871329-58-7 | C10H16BNO4S |
|
| N,N-二乙基-3-硝基苯磺酰胺 | 3-nitro-benzenesulfonic acid diethylamide | 6335-26-8 | C10H14N2O4S |
|
| N,N-二乙基-3-溴苯磺酰胺 | 3-bromo-N,N-diethylbenzenesulfonamide | 871269-11-3 | C10H14BrNO2S |
|
| N,N-二乙基-3-氨基苯磺酰胺 | 3-amino-N,N-diethylbenzenesulfonamide | 10372-41-5 | C10H16N2O2S |
|
| 5-溴砒啶-3-磺酰胺 | 5-bromopyridine-3-sulfonamide | 62009-33-0 | C5H5BrN2O2S |
|
| 5-溴-N-叔丁基-2-甲氧基苯磺酰胺 | 5-Bromo-N-t-butyl-2-methoxybenzenesulfonamide | 871269-15-7 | C11H16BrNO3S |
|
| 5-溴-N-丁基-2-甲氧基苯磺酰胺 | 5-bromo-N-butyl-2-methoxybenzenesulfonamide | 871269-18-0 | C11H16BrNO3S |
|
| 5-溴-N-(2-羟基乙基)-2-甲氧基苯磺酰胺 | 5-bromo-N-(2-hydroxyethyl)-2-methoxy-benzenesulfonamide | 871269-14-6 | C9H12BrNO4S |
|
| 5-溴-N,N-二乙基砒啶-3-磺酰胺 | 5-bromo-pyridine-3-sulfonic acid diethylamide | 62009-37-4 | C9H13BrN2O2S |
|
| 5-溴-2-甲氧基苯磺酰胺 | 5-bromo-2-methoxybenzenesulfonamide | 23095-14-9 | C7H8BrNO3S |
|
| 5-溴-2-甲氧基-N-甲基苯磺酰胺 | 5-bromo-2-methoxy-N-methylbenzenesulfonamide | 871269-17-9 | C8H10BrNO3S |
|
| 5-溴-2-甲氧基-N,N-二甲基苯磺酰胺 | 5-bromo-2-methoxy-N,N-dimethylbenzenesulfonamide | 871269-16-8 | C9H12BrNO3S |
|
| 5-二乙基磺酰胺基-2-甲基苯硼酸 | N,N-Diethyl 3-borono-4-methylbenzenesulfonamide | 871329-80-5 | C11H18BNO4S |
|
| 4-磺酰基丁酸 | 3-carboxypropanesulfonamide | 175476-52-5 | C4H9NO4S |
|
| 4-硼苯磺酰胺甲酯 | (4-[N-methylsulfamoyl]phenyl)boronic acid | 226396-31-2 | C7H10BNO4S |
|
| 4-硼苯磺酰胺叔丁酯 | 4-(N-tert-butylsulfamoyl)phenylboronic acid | 208516-15-8 | C10H16BNO4S |
|
| 4-甲酰基-N,N-二甲基-1H-咪唑-1-磺酰胺 | 4-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide | 140174-48-7 | C6H9N3O3S |
|
| 4-甲氧基苯基甲磺酸 | p-methoxyphenyl mesylate | 19013-30-0 | C8H10O4S |
|
| 4-甲氧基-3-(1-哌啶基磺酰基)苯硼酸 | (4-Methoxy-3-(piperidin-1-ylsulfonyl)phenyl)boronic acid | 874219-18-8 | C12H18BNO5S |
|
| 4-甲氧基-3-(1-吡咯烷基磺酰基)苯硼酸 | 4-methoxy-3-(pyrrolidin-1-ylsulfonyl)phenylboronic acid | 874219-52-0 | C11H16BNO5S |
|
| 4-溴-n-(4-甲氧基苄基)苯磺胺 | 4-bromo-N-(4-methoxybenzyl)benzenesulfonamide | 329939-43-7 | C14H14BrNO3S |
|
| 4-溴-N-[2-(TBDMSO)乙基]苯磺酰胺 | 4-Bromo-N-[2-(tert-butyldimethylsilyloxy)ethyl]benzenesulphonamide | 850429-52-6 | C14H24BrNO3SSi |
|
| 4-溴-N,N-二甲基苯磺酰胺 | 4-bromo-N,N-dimethylbenzenesulfonamide | 707-60-8 | C8H10BrNO2S |
|
| 4-溴-N,N,3-三甲基苯磺酰胺 | 4-bromo-3-N,N-trimethylbenzenesulphonamide | 849532-31-6 | C9H12BrNO2S |
|
| 4-氨基-N-2-嘧啶基苯磺酰胺-2,3,5,6-d4 | sulfadiazine-d4 | 1020719-78-1 | C10H10N4O2S |
|
| 4-氧代-1,4-丁烷磺内酰胺 | 1,2-Thiazinan-3-one 1,1-dioxide | 913836-20-1 | C4H7NO3S |
|
| 4-N-(甲基磺酰胺)苯硼酸 | 4-(methylsulfonylamino)phenyl boronic acid | 380430-57-9 | C7H10BNO4S |
|
| 4-(磺酰吡咯啉)苯基硼酸 | (4-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid | 486422-57-5 | C10H14BNO4S |
|
| 4-(硫代吗啉磺酰)苯基硼酸 | [4-(thiomorpholin-4-ylsulphonyl)phenyl]boronic acid | 871329-69-0 | C10H14BNO4S2 |
|
| 4-(砒啶-3-基磺酰)吗啉 | 3-Morpholinosulfonylpyridine | 26103-48-0 | C9H12N2O3S |
|
| 4-(哌啶-1-基磺酰)苯基硼酸 | (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid | 486422-58-6 | C11H16BNO4S |
|
| 4-(5-溴-2-甲氧基苯基磺酰)吗啉 | 4-((5-bromo-2-methoxyphenyl)sulfonyl)morpholine | 325809-68-5 | C11H14BrNO4S |
|
| 4-(4-溴苯基磺酰)吗啉 | 4-((4-bromophenyl)sulfonyl)morpholine | 834-67-3 | C10H12BrNO3S |
|
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