磺胺类药及增效剂
磺胺类药物在20世纪30年代迅速发展，临床应用的种类曾多达20余种。然而，40年代以后随着青霉素等抗生素的出现，其在化学治疗中的地位有所下降。尽管如此，磺胺类药物仍因其广谱抗菌、疗效确切、可口服且吸收较快等特点而备受青睐。与甲氧苄啶（Trimethoprim）合用时，其抗菌作用会显著增强，仍然是较为常用的抗菌药物之一。
磺胺类药物的作用机制得以阐明后，确立了抗代谢学说，为新药的研发开辟了一条新的途径。目前临床上使用较多的磺胺类药物包括磺胺嘧啶（Sulfadiazine）和磺胺甲噁唑（Sulfamethoxazole）。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| 4-N-(甲基磺酰胺)苯硼酸 | 4-(methylsulfonylamino)phenyl boronic acid | 380430-57-9 | C7H10BNO4S |
| 4-(磺酰吡咯啉)苯基硼酸 | (4-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid | 486422-57-5 | C10H14BNO4S |
| 4-(硫代吗啉磺酰)苯基硼酸 | [4-(thiomorpholin-4-ylsulphonyl)phenyl]boronic acid | 871329-69-0 | C10H14BNO4S2 |
| 4-(砒啶-3-基磺酰)吗啉 | 3-Morpholinosulfonylpyridine | 26103-48-0 | C9H12N2O3S |
| 4-(哌啶-1-基磺酰)苯基硼酸 | (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid | 486422-58-6 | C11H16BNO4S |
| 4-(5-溴-2-甲氧基苯基磺酰)吗啉 | 4-((5-bromo-2-methoxyphenyl)sulfonyl)morpholine | 325809-68-5 | C11H14BrNO4S |
| 4-(4-溴苯基磺酰)吗啉 | 4-((4-bromophenyl)sulfonyl)morpholine | 834-67-3 | C10H12BrNO3S |
| 4-(3-硝基苯基磺酰)吗啉 | 4-<3-Nitro-benzol-sulfonyl-(1)>-morpholin | 91619-33-9 | C10H12N2O5S |
| 4-(3-溴苯基磺酰)吗啉 | 4-((3-bromophenyl)sulfonyl)morpholine | 871269-13-5 | C10H12BrNO3S |
| 4-(2-溴苯基磺酰)吗啉 | 4-((2-bromophenyl)sulfonyl)morpholine | 688798-57-4 | C10H12BrNO3S |
| 4-(1-丫啶基磺酰基)苯硼酸 | (4-(azetidin-1-ylsulfonyl)phenyl)boronic acid | 871329-68-9 | C9H12BNO4S |
| 3-苄基磺酰胺基-4-甲氧基苯硼酸 | [4-Methoxy-3-(phenylsulfamoyl)phenyl]boronic acid | 874219-51-9 | C13H14BNO5S |
| 3-硼苯磺酰胺甲酯 | (3-(N-methylsulfamoyl)phenyl)boronic acid | 871329-75-8 | C7H10BNO4S |
| 3-硼苯磺酰胺叔丁酯 | N-t-butyl 3-boronobenzenesulfonamide | 221290-14-8 | C10H16BNO4S |
| 3-硼苯磺酰胺乙酯 | Ethyl 3-boronobenzenesulfonamide | 871329-76-9 | C8H12BNO4S |
| 3-硼苯磺酰胺 | (3-sulfamoylphenyl)boronic acid | 850568-74-0 | C6H8BNO4S |
| 3-硝基苯磺酰胺 | 3-nitrophenylsulfonamide | 121-52-8 | C6H6N2O4S |
| 3-甲磺酰氨基苯硼酸 | 3-(methylsulfonamido)phenylboronic acid | 148355-75-3 | C7H10BNO4S |
| 3-溴苯磺胺 | 3-bromobenzenesulfonamide | 89599-01-9 | C6H6BrNO2S |
| 3-溴-N-环丙基苯磺酰胺 | 3-bromo-N-cyclopropylbenzenesulfonamide | 876694-43-8 | C9H10BrNO2S |
| 3-溴-N-丙基苯甲酰胺 | 3-bromo-N-propylbenzamide | 35306-74-2 | C10H12BrNO |
| 3-溴-N-(3-氯丙基)苯磺酰胺 | 3-Bromo-N-(3-chloropropyl)benzenesulfonamide | 929000-46-4 | C9H11BrClNO2S |
| 3-溴-N-(2-羟基乙基)苯磺酰胺 | 3-bromo-N-(2-hydroxy-ethyl)-benzenesulfonamide | 911111-96-1 | C8H10BrNO3S |
| 3-溴-N,4-二甲基苯磺酰胺 | 3-bromo-N,4-dimethylbenzenesulfonamide | 941294-51-5 | C8H10BrNO2S |
| 3-溴-4-甲基苯磺酰胺 | 3-bromo-4-methylbenzenesulfonamide | 210824-69-4 | C7H8BrNO2S |
| 3-氰基苯硼酸 | 3-cyanophenylboronic acid | 150255-96-2 | C7H6BNO2 |
| 3-哌啶磺酰苯胺 | 3-(piperidin-1-ylsulfonyl)aniline | 22184-99-2 | C11H16N2O2S |
| 3-[2-(1-吡咯烷基)乙基氨甲酰基]苯硼酸盐酸盐 | (3-((2-(Pyrrolidin-1-yl)ethyl)carbamoyl)phenyl)boronic acid hydrochloride | 957061-03-9 | C13H20BClN2O3 |
| 3-N-吗啉基磺酰苯基硼酸 | 3-(morpholinosulfonyl)phenylboronic acid | 871329-60-1 | C10H14BNO5S |
| 3-(环己基磺酰胺基)苯硼酸 | N-Cyclohexyl 3-boronobenzenesulfonamide | 871329-79-2 | C12H18BNO4S |
| 3-(哌啶-1-基磺酰)苯基硼酸 | 3-(piperidin-1-ylsulfonyl)phenylboronic acid | 690662-96-5 | C11H16BNO4S |
| 3-(哌啶-1-基磺酰)砒啶 | 1-(3-pyridinylsulfonyl)piperidine | 26103-49-1 | C10H14N2O2S |
| 3-(吡咯啉-1-基磺酰)砒啶 | 3-(pyrrolidin-1-ylsulfonyl)pyridine | 26103-51-5 | C9H12N2O2S |
| 3-(4-氯磺酰基)丙酸 | 3-(4-(chlorosulfonyl)phenyl)propanoic acid | 63545-54-0 | C9H9ClO4S |
| 3-(3-溴苯基磺酰氨基)苯基硼酸 | (3-(3-Bromophenylsulfonamido)phenyl)boronic acid | 913835-31-1 | C12H11BBrNO4S |
| 3-(1-吡咯烷基磺酰基)苯硼酸 | (3-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid | 871329-61-2 | C10H14BNO4S |
| 3-(1-吡咯基磺酰)苯胺 | 3-(pyrrolidin-1-ylsulfonyl)benzenamine | 91619-38-4 | C10H14N2O2S |
| 2‘-三氟甲基联苯-3-羧醛 | 3-(morpholinosulfonyl)aniline | 22184-97-0 | C10H14N2O3S |
| 2-磺酰吡咯啉苯硼酸 | 2-(pyrrolidinylsulfonyl)phenylboronic acid | 913835-83-3 | C10H14BNO4S |
| 2-甲磺酰氨基苯硼酸 | (2-(methylsulfonamido)phenyl)boronic acid | 756520-78-2 | C7H10BNO4S |
| 2-甲烷磺酰氨基苯基硼酸频哪醇酯 | N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-methane-sulfonamide | 380430-60-4 | C13H20BNO4S |
| 2-甲基-5-(哌啶-1-基磺酰)苯基硼酸 | (2-Methyl-5-(piperidin-1-ylsulfonyl)phenyl)boronic acid | 871333-00-5 | C12H18BNO4S |
| 2-甲基-5-(吡咯啉-1-基磺酰)苯基硼酸 | [2-methyl-5-(pyrrolidin-1-ylsulphonyl)phenyl]boronic acid | 871333-01-6 | C11H16BNO4S |
| 2-甲基-5-(4-吗啉基磺酰基)苯硼酸 | [2-methyl-5-(morpholine-4-sulfonyl)phenyl]boronic acid | 871329-74-7 | C11H16BNO5S |
| 2-溴苯磺酰氯 | o-bromobenzenesulfonyl chloride | 2905-25-1 | C6H4BrClO2S |
| 2-溴-n-异丙基苯磺酰胺 | 2-bromo-N-isopropylbenzenesulfonamide | 951883-94-6 | C9H12BrNO2S |
| 2-溴-N-苯乙基苯磺酰胺 | 2-bromo-N-(2-phenylethyl)benzenesulfonamide | 849141-69-1 | C14H14BrNO2S |
| 2-溴-N-甲基苯磺酰胺 | 2-bromo-N-methylbenzenesulfonamide | 98192-14-4 | C7H8BrNO2S |
| 2-溴-N-叔丁基苯磺酰胺 | N-(1,1-dimethylethyl)-2-bromobenzenesulfonamide | 138733-50-3 | C10H14BrNO2S |
| 2-溴-N-乙基苯磺酰胺 | 2-bromo-N-ethylbenzenesulfonamide | 169189-80-4 | C8H10BrNO2S |
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