异喹啉类化合物
异喹啉是一种含苯环和吡啶环的杂环化合物，是喹啉的一种同分异构体，即由萘分子中β位的CH基被N原子取代而成。它通常呈现为无色至浅黄色的液体或片状结晶，并带有类似茴香油和苯甲醛的刺激性气味，具有较强的吸水性和较高的碱性。化学性质活泼，能够发生亲核、亲电、氧化及还原反应。许多生物碱如罂粟碱、小蘖碱和吗啡碱等分子中均含有异喹啉或氢化异喹啉的基本结构。
异喹啉的应用广泛：可用作聚亚胺薄膜溶剂；有机导电体、染料、感光色素、杀虫剂、生物碱及医药制品的原料；通过氧化反应制备吡啶羧酸；而异喹啉盐酸盐则常用于测定锌、镉、钴和铜等金属；此外，还可以用来制备各种异喹啉衍生物。
其合成方法包括：一种于1893年提出的Bischler法。该方法以β-苯乙胺的酰基化物为原料，在五氧化二磷（或ZnCl2、POCl3等）的作用下脱水缩合闭环，生成3,4-二氢异喹啉；然后在钯催化作用下于190℃条件下进行氧化脱氢反应以制备异喹啉。另一种方法则是通过肉桂醛肟的Beckmann重排，在五氧化二磷（或硫酸、多聚磷酸）的作用下进行闭环生成所需产物。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 8-异喹啉甲酸甲酯 | Methyl isoquinoline-8-carboxylate | 850858-56-9 | C11H9NO2 |
|
| 8-异喹啉甲酸乙酯 | Ethyl isoquinoline-8-carboxylate | 1261871-20-8 | C12H11NO2 |
|
| 8-异喹啉甲酸 | Isoquinoline-8-carboxylic acid | 61563-43-7 | C10H7NO2 |
|
| 7-羟基-6-甲氧基-3,4-二氢异喹啉 | 7-hydroxy-6-methoxy-3,4-dihydroisoquinoline | 4602-73-7 | C10H11NO2 |
|
| 7-羟基-2-喹诺酮 | 7-hydroxy-1H-quinolin-2-one | 70500-72-0 | C9H7NO2 |
|
| 7-碘异喹啉 | 7-Iodoisoquinoline | 75476-83-4 | C9H6IN |
|
| 7-硝基异喹啉-1(2H)-酮 | 7-nitroisoquinolin-1(2H)-one | 20141-83-7 | C9H6N2O3 |
|
| 7-硝基异喹啉 | 7-nitroisoquinoline | 13058-73-6 | C9H6N2O2 |
|
| 7-硝基-1,2,3,4-四氢异喹啉 | 7-nitro-1,2,3,4-tetrahydroisoquinoline | 42923-79-5 | C9H10N2O2 |
|
| 7-甲氧基-3-甲基异喹啉 | 7-methoxy-3-methylisoquinoline | 40134-07-4 | C11H11NO |
|
| 7-甲氧基-2-甲基-4H-异喹啉-1,3-二酮 | 7-methoxy-2-methylisoquinoline-1,3(2H,4H)-dione | 76746-95-7 | C11H11NO3 |
|
| 7-甲氧基-1(2H)-异喹啉酮 | 7-methoxyisoquinolin-1(2H)-one | 16027-16-0 | C10H9NO2 |
|
| 7-甲基异喹啉 | 7-methylisoquinoline | 54004-38-5 | C10H9N |
|
| 7-甲基-6-羟基异喹啉 | 7-Methylisoquinolin-6-ol | 666735-06-4 | C10H9NO |
|
| 7-甲基-3,4-二氢异喹啉 | 7-methyl-3,4-dihydroisoquinoline | 102652-86-8 | C10H11N |
|
| 7-甲基-1(2H)-异喹啉酮 | 7-methylisoquinolin-1(2H)-one | 26829-47-0 | C10H9NO |
|
| 7-溴异喹啉盐酸盐 | 7-bromoisoquinoline hydrochloride | 223671-91-8 | C9H6BrN*ClH |
|
| 7-溴异喹啉-3-胺 | 7-bromoisoquinolin-3-amine | 1192815-02-3 | C9H7BrN2 |
|
| 7-溴异喹啉-3-甲酸乙酯 | ethyl 7-bromoisoquinoline-3-carboxylate | 660830-62-6 | C12H10BrNO2 |
|
| 7-溴异喹啉 | 7-bromoisoquinoline | 58794-09-5 | C9H6BrN |
|
| 7-溴-4-氯异喹啉-1(2H)-酮 | 7-bromo-4-chloro-2H-isoquinolin-1-one | 223671-87-2 | C9H5BrClNO |
|
| 7-溴-3-氯异喹啉 | 7-bromo-3-chloroisoquinoline | 1029720-65-7 | C9H5BrClN |
|
| 7-溴-1,3-二氯异喹啉 | 7-bromo-1,3-dichloroisoquinoline | 924271-40-9 | C9H4BrCl2N |
|
| 7-氰基异喹啉 | 7-cyanoisoquinoline | 223671-92-9 | C10H6N2 |
|
| 7-氯异喹啉-3-胺 | 7-chloroisoquinolin-3-amine | 82117-29-1 | C9H7ClN2 |
|
| 7-氯异喹啉-3-羧酸 | 7-Chloroisoquinoline-3-carboxylic acid | 234098-55-6 | C10H6ClNO2 |
|
| 7-氯异喹啉 | 7-chloroisoquinoline | 34784-06-0 | C9H6ClN |
|
| 7-氯-5-氨基-异喹啉 | 7-chloroisoquinolin-5-amine | 608515-70-4 | C9H7ClN2 |
|
| 7-氯-1-羟基异喹啉 | 7-chloroisoquinolin-1(2H)-one | 24188-74-7 | C9H6ClNO |
|
| 7-氨基-1,2,3,4-四氢异喹啉甲酸叔丁酯 | tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | 171049-41-5 | C14H20N2O2 |
|
| 7-氨基-1,2,3,4-四氢异喹啉 | 1,2,3,4-tetrahydroisoquinolin-7-amine | 72299-68-4 | C9H12N2 |
|
| 7-氟-3,4-二氢-2H-异喹啉-1-酮 | 7-fluoro-3,4-dihydro-2H-isoquinolin-1-one | 885273-83-6 | C9H8FNO |
|
| 7-氟-1,2,3,4-四氢异喹啉 | 7-fluoro-1,2,3,4-tetrahydroisoquinoline | 406923-91-9 | C9H10FN |
|
| 7-异喹啉羧酸甲酯 | methyl isoquinoline-7-carboxylate | 178262-31-2 | C11H9NO2 |
|
| 7-异喹啉羧酸乙酯 | 7-ethoxycarbonylisoquinoline | 407623-83-0 | C12H11NO2 |
|
| 7-异喹啉甲酸 | 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid hydrochloride | 220247-71-2 | C10H11NO2*ClH |
|
| 7-异喹啉氧基乙酸 | 2-(isoquinolin-7-yloxy)acetic acid | 86235-60-1 | C11H9NO3 |
|
| 7-(溴甲基)异喹啉,氢溴酸盐 | 7-(bromomethyl)isoquinoline hydrobromide | 1203372-02-4 | BrH*C10H8BrN |
|
| 7-(溴甲基)异喹啉 | 7-(bromomethyl) isoquinoline | 158654-75-2 | C10H8BrN |
|
| 7-(溴甲基)-1-氯异喹啉 | 7-bromomethyl-1-chloro-isoquinoline | 209285-92-7 | C10H7BrClN |
|
| 7,8-甲氧基-四氢异喹啉 | 1,2,3,4-tetrahydro-7,8-dimethoxyisoquinoline | 52759-08-7 | C11H15NO2 |
|
| 7,8-二氢-6H-异喹啉-5-酮 | 7,8-dihydroisoquinolin-5(6H)-one | 21917-86-2 | C9H9NO |
|
| 6-羟基异喹啉-1(2H)-酮 | 6-hydroxyisoquinolin-1(2H)-one | 252061-78-2 | C9H7NO2 |
|
| 6-羟基-2-甲基-3,4-二氢异喹啉-1(2H)-酮 | 6-hydroxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one | 308110-07-8 | C10H11NO2 |
|
| 6-甲氧基异喹啉盐酸盐 | 6-Methoxyisoquinoline hydrochloride | 915865-96-2 | C10H10ClNO |
|
| 6-甲氧基异喹啉-1-胺 | 6-methoxyisoquinolin-1-amine | 266690-48-6 | C10H10N2O |
|
| 6-甲氧基-5-硝基异喹啉 | 6-methoxy-5-nitroisoquinoline | 72677-92-0 | C10H8N2O3 |
|
| 6-甲氧基-5-异喹啉甲腈 | 5-Cyano-6-methoxyisochinolin | 925931-94-8 | C11H8N2O |
|
| 6-甲氧基-3-甲基异喹啉 | 6-methoxy-3-methylisoquinoline | 14446-31-2 | C11H11NO |
|
| 6-甲氧基-3,4-二氢-1(2H)-异喹啉 | 6-methoxy-1,2,3,4-tetrahydro-1-oxoisoquinoline | 22246-12-4 | C10H11NO2 |
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