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哌嗪类化合物

哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体,广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪,以及氟奋乃静、强痛定和利福平等其他药物。此外,这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂,以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。

哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶,具有温和的胺臭和咸味,并具备吸湿性。其相对密度为0.876,熔点为106.6℃,沸点为146℃。该化合物易溶于水和甘油,微溶于乙醇而不溶于乙醚。哌嗪具有强碱性,10%的水溶液pH值在10.8~11.8之间,并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用,具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物,是驱除蛔虫、蛲虫的有效药物,并用于有机合成。

哌嗪又称为“驱蛔灵”,对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹,防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象,相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病,亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%~80%,连续用药2天可提高治愈率。治疗蛲虫病需连续服药7~10天。该药物毒性较低,治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。

中文名称 英文名称 CAS号 化学式
1,4-双(3-氨基丙基)哌嗪 1,4-bis(3-aminopropyl)piperazine 7209-38-3 C10H24N4
1,4-双(2-羧乙基)哌嗪 3,3'-(piperazine-1,4-diyl)dipropanoic acid 5649-49-0 C10H18N2O4
1,4-二苯基哌嗪 1,4-diphenyl-piperazine 613-39-8 C16H18N2
1,4-二苄基哌嗪-2-羧酸乙酯 ethyl 1,4-dibenzylpiperazin-2-carboxylate 72351-59-8 C21H26N2O2
1,4-二甲基哌嗪-2,3-二酮 1,4-dimethyl-2,3-dioxopiperazine 59417-06-0 C6H10N2O2
1,4-二甲基哌嗪 1,4-dimethylpiperazine 106-58-1 C6H14N2
1,4-二叔丁基2-(氨基甲基)哌嗪-1,4-二羧酸 di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate 1256815-07-2 C15H29N3O4
1,4-二乙酰基哌嗪-2,5-二酮 N,N'-diacetylpiperazin-2,5-dione 3027-05-2 C8H10N2O4
1,4-二乙基哌嗪 1,4-diethylpiperazine 6483-50-7 C8H18N2
1,4-二丙烯酰基哌嗪 1,4-diacryloylpiperazine 6342-17-2 C10H14N2O2
1,4-二(4-亚硝基苯基)哌嗪 di-(4-nitrosophenyl)-N,N-piperazine 4963-30-8 C16H16N4O2
1,3-二甲基-哌嗪 1,3-dimethyl-piperazine 22317-01-7 C6H14N2
1,1,4,4-四甲基哌嗪二鎓二碘化物 Tetramethylpiperazinium diiodide 6952-20-1 C8H20I2N2
(S)-4-苯甲基-2-哌嗪乙醇 (S)-2-(4-benzylpiperazin-2-yl)ethanol 477220-33-0 C13H20N2O
(S)-4-N-叔丁氧羰基-2-甲基哌嗪 (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 147081-29-6 C10H20N2O2
(S)-2-哌嗪甲醇二盐酸盐 (S)-Piperazin-2-ylmethanol dihydrochloride 149629-73-2 C5H14Cl2N2O
(S)-2-三氟甲基-哌嗪 (2S)-2-(trifluoromethyl)piperazine 1187931-35-6 C5H9F3N2
(S)-1,4-n-二boc-2-哌嗪-2-羧酸 (S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 788799-69-9 C15H26N2O6
(S)-(+)-2-甲基哌嗪 (S)-2-methylpiperazine 74879-18-8 C5H12N2
(R)-哌嗪-2-羧酸二盐酸盐 (R)-Piperazine-2-carboxylic acid dihydrochloride 126330-90-3 C5H12Cl2N2O2
(R)-N-1-Boc-N-4-Cbz-2-哌嗪甲酸 (2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid 138775-02-7 C18H24N2O6
(R)-4-Boc-2-甲基哌嗪 (R)-tert-butyl 3-methylpiperazine-1-carboxylate 163765-44-4 C10H20N2O2
(R)-4-(2,4-二甲氧基苄基)-3-甲基哌嗪-2-酮 (R)-4-(2,4-dimethoxybenzyl)-3-methylpiperazin-2-one 1383146-20-0 C14H20N2O3
(R)-3-甲基哌嗪-2-酮 (R)-3-methylpiperazin-2-one 922178-61-8 C5H10N2O
(R)-2-甲基哌嗪双盐酸盐 (R)-2-Methylpiperazine dihydrochloride 75336-89-9 C5H14Cl2N2
(R)-2-甲基-1-哌嗪甲酸苄酯 (R)-benzyl 2-methylpiperazine-1-carboxylate 923565-99-5 C13H18N2O2
(R)-2-乙基哌嗪二盐酸盐 (R)-2-ethylpiperazine dihydrochloride 438050-07-8 C6H16Cl2N2
(R)-1-叔丁氧羰基-3-乙基哌嗪 tert-butyl (R)-3-ethylpiperazine-1-carboxylate 438050-08-9 C11H22N2O2
(R)-1-n-boc-4-n-boc-哌嗪-2-羧酸 (R)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid 173774-48-6 C15H26N2O6
(R)-1-N-Boc-2-甲基哌嗪 (R)-tert-butyl 2-methylpiperazine-1-carboxylate 170033-47-3 C10H20N2O2
(R)-1,3-二甲基哌嗪-2-酮盐酸盐 (R)-1,3-dimethylpiperazine-2-one hydrochloride 1373232-29-1 C6H12N2O*ClH
(R)-(-)-2-甲基哌嗪 (2R)-methylpiperazine 75336-86-6 C5H12N2
(5-甲基-3-氧代-2-哌嗪基)乙酸 (5-Methyl-3-oxopiperazin-2-yl)acetic acid 405214-35-9 C7H12N2O3
(3S)-3-(羟基甲基)-1-哌嗪羧酸苯基甲酯 benzyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate 930837-02-8 C13H18N2O3
(3S)-1-苄氧基羰基-3-甲基哌嗪 benzyl (3S)-3-methylpiperazine-1-carboxylate 612493-87-5 C13H18N2O2
(2R,5S)-2,5-二甲基哌嗪-1-甲酸叔丁酯 tert-butyl (2R,5S)-2,5-dimethylpiperazine-1-carboxylate 309915-46-6 C11H22N2O2
(2R)-2-甲基-1-哌嗪甲酸叔丁酯盐酸盐 (R)-tert-butyl 2-methylpiperazine-1-carboxylate hydrochloride 1000853-53-1 C10H20N2O2*ClH
(2R)-1,2-二甲基哌嗪 (2R)-1,2-dimethylpiperazine 623586-02-7 C6H14N2
(1-环辛基)哌嗪 1-cyclooctylpiperazine 21043-43-6 C12H24N2
(-)-1-[(4-氯苯基)苯甲基]哌嗪 (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine 300543-56-0 C17H19ClN2
—— 4-(3-chloropropyl)piperazine-1-ethanol dihydrochloride 3445-00-9 C9H19ClN2O*2ClH
—— 1-(1H-imidazol-2-yl)piperazine dihydrochloride 1795503-50-2 C7H14Cl2N4
—— 1-amino-4-cyclobutylpiperazine 61379-68-8 C8H17N3
—— (2R,6R)-2,6-dimethylpiperazine dihydrochloride 162240-93-9 C6H14N2*2ClH
—— Acefylline piperazine 18833-13-1 C22H30N10O8
—— 1-(2-Chloroethyl)-4-methylpiperazine dihydrochloride 5753-26-4 C7H17Cl3N2
—— 1,4-Piperazinedicarbodithioic acid, dipotassium salt 40839-73-4 C6H8N2S4*2K
—— Acefylline Piperazine 18833-13-1 C100H150N46O32
—— N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine 295330-45-9 C22H25ClFN5O2
—— 2-(1-piperazinyl)quinoline hydrochloride 928026-67-9 C13H15N3*ClH