哌嗪类化合物
哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体，广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪，以及氟奋乃静、强痛定和利福平等其他药物。此外，这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂，以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。
哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶，具有温和的胺臭和咸味，并具备吸湿性。其相对密度为0.876，熔点为106.6℃，沸点为146℃。该化合物易溶于水和甘油，微溶于乙醇而不溶于乙醚。哌嗪具有强碱性，10%的水溶液pH值在10.8～11.8之间，并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用，具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物，是驱除蛔虫、蛲虫的有效药物，并用于有机合成。
哌嗪又称为“驱蛔灵”，对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹，防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象，相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病，亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%～80%，连续用药2天可提高治愈率。治疗蛲虫病需连续服药7～10天。该药物毒性较低，治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 |
|---|---|---|---|
| —— | 3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | 957147-18-1 | C23H24F3N3O |
| —— | 1-(3-Phenylprop-2-enyl)piperazine hydrochloride | 163596-56-3 | C13H18N2*ClH |
| —— | N,N''-bis[[(4-chlorophenyl)amino]iminomethyl]piperazine-1,4-dicarboxamidine dihydrochloride | 19803-62-4 | C20H24Cl2N10*(x)ClH |
| —— | trans-1-cinnamylpiperazine dihydrochloride | 163596-56-3 | C13H18N2*2ClH |
| —— | Methyl[1-(piperidin-4-yl)pyridin-4(1H)-ylidene]oxidanium chloride | 84145-43-7 | C11H17ClN2O |
| —— | 6-(Piperazin-1-yl)pyrimidin-4-amine | 1159820-98-0 | C8H13N5 |
| —— | N-(3-methylbenzyl)piperazine diHCl | 5321-61-9 | C12H18N2*2ClH |
| —— | N-(tert-Butoxycarbonyl)-3-[4-(tert-butoxycarbonyl)piperazin-1-yl]-L-alanine | 1334509-91-9 | C17H31N3O6 |
| —— | N,N,N',N'-Tetramethylpiperazinium diiodide | 6952-20-1 | C8H20N2*2I |
| —— | 1-docosyl-piperazine | 1018908-25-2 | C26H54N2 |
| —— | (R)-piperazine-2-carboxylic acid dihydrochloride | 126330-90-3 | C5H10N2O2*2ClH |
| —— | 1,2-dimethylpiperazine | 25155-35-5 | C6H14N2 |
| —— | 4-benzyl 1-tert-butyl 2-methylpiperazine-1,4-dicarboxylate | 128102-16-9 | C18H26N2O4 |
| —— | 1-(2,2,2-trifluoroethyl)piperazine dihydrochloride | 13349-91-2 | C6H11F3N2*2ClH |
| —— | Piperazine Citrate | 144-29-6 | C24H46N6O14 |
| —— | 4-(Carboxy{[(4-ethyl-2,3-dioxopiperazin-1-yl)(hydroxy)methylidene]amino}methyl)phenolate | 62893-24-7 | C15H16N3O6- |
| —— | 4-(Oxolane-2-carbonyl)piperazin-1-ium | 63074-07-7 | C9H17N2O2+ |
| —— | 4-(2,3-Dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-ium | 70918-00-2 | C13H17N2O3+ |
| —— | 4-Piperidinobenzoate | 22090-24-0 | C12H14NO2- |
| —— | N8Jtw437BS | 886025-85-0 | C13H17N3O3 |
| —— | 4-(dimethylamino)-1,2,2,6,6-pentamethyl-piperidine | 52185-74-7 | C12H26N2 |
| —— | 1-methylethylpiperazine dihydrochloride | 88569-66-8 | C7H16N2*2ClH |
| —— | 1-(2-Chloroethyl)-4-[3-(trifluoromethyl)phenyl]piperazine dihydrochloride | 57061-71-9 | C13H18Cl3F3N2 |
| —— | 4-hydroxyethylpiperazine hydrochloride | 5712-71-0 | C6H14N2O*ClH |
| —— | 1-[2-(2-chloro-benzhydryloxy)-ethyl]-4-(2-methyl-benzyl)-piperazine; dihydrochloride | 5576-62-5 | C27H31ClN2O*2ClH |
| —— | N,N′-piperazine(bismethylenephosphonic acid) | 89280-71-7 | C6H16N2O6P2 |
| —— | piperazine hexahydrate | 142-63-2 | C4H10N2*6H2O |
| —— | (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]succinic acid {(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-(2-methoxy-5-(trifluormethyl)phenyl)-3,4-dihydroquinazolin-4-yl}acetic acid methyl ester | 917389-30-1 | C20H18O8*C30H30F4N4O4 |
| —— | 1-(4-methylphenyl)piperazine hydrochloride | 13078-14-3 | C11H16N2*ClH |
| —— | 1-(2-methoxyphenyl)piperazine hydrochloride | 66373-53-3 | C11H16N2O*ClH |
| —— | 1-(4-fluorophenyl)piperazine dihydrochloride | 64090-19-3 | C10H13FN2*2ClH |
| —— | 3-phenyl-1-(piperazin-1-yl)prop-2-en-1-one | 55486-27-6 | C13H16N2O |
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