哌嗪类化合物
哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体，广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪，以及氟奋乃静、强痛定和利福平等其他药物。此外，这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂，以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。
哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶，具有温和的胺臭和咸味，并具备吸湿性。其相对密度为0.876，熔点为106.6℃，沸点为146℃。该化合物易溶于水和甘油，微溶于乙醇而不溶于乙醚。哌嗪具有强碱性，10%的水溶液pH值在10.8～11.8之间，并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用，具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物，是驱除蛔虫、蛲虫的有效药物，并用于有机合成。
哌嗪又称为“驱蛔灵”，对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹，防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象，相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病，亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%～80%，连续用药2天可提高治愈率。治疗蛲虫病需连续服药7～10天。该药物毒性较低，治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 4-哌嗪基苯甲腈 | 1-(4-Cyanophenyl)piperazine | 68104-63-2 | C11H13N3 |
|
| 4-哌嗪基苯并噻吩盐酸盐 | 1-(benzo[b]thiophen-4-yl)piperazine | 846038-18-4 | C12H14N2S |
|
| 4-哌嗪哌啶 | 1-(4-piperidinyl)piperazine | 142013-66-9 | C9H19N3 |
|
| 4-哌嗪-1-基喹啉 | 4-piperazinylquinoline | 118306-89-1 | C13H15N3 |
|
| 4-乙基-2,3-二氧-1-哌嗪甲酰氯 | 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride | 59703-00-3 | C7H9ClN2O3 |
|
| 4-[4-[[2-(4-氯苯基)-5,5-二甲基-1-环己烯]甲基]-1-哌嗪]苯甲酸 | 4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid | 1044598-91-5 | C26H31ClN2O2 |
|
| 4-N-CBZ-2-羟甲基哌嗪 | benzyl 3-(hydroxymethyl)piperazine-1-carboxylate | 191739-40-9 | C13H18N2O3 |
|
| 4-Cbz-2-哌嗪酮 | 4-benzyloxycarbonylpiperazin-2-one | 78818-15-2 | C12H14N2O3 |
|
| 4-Boc-哌嗪-2-羧酸 | 4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid | 128019-59-0 | C10H18N2O4 |
|
| 4-(环丙烷羰基)哌嗪-1-羧酸叔丁酯 | 1-tert-butoxycarbonyl-4-(cyclopropanecarbonyl)piperazine | 414910-15-9 | C13H22N2O3 |
|
| 4-(氧乙烷-3-基)哌嗪-1-羧酸苄酯 | benzyl 4-(oxetan-3-yl)piperazine-1-carboxylate | 1254115-22-4 | C15H20N2O3 |
|
| 4-(异喹啉-1-基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(isoquinolin-1-yl)piperazine-1-carboxylate | 205264-33-1 | C18H23N3O2 |
|
| 4-(哌嗪-1-基)嘧啶 | 4-(piperazin-1-yl)pyrimidine | 51047-52-0 | C8H12N4 |
|
| 4-(6-硝基-3-吡啶基)-1-哌嗪甲酸叔丁酯 | tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate | 571189-16-7 | C14H20N4O4 |
|
| 4-(6-(甲氧羰基)吡啶-3-基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(6-(methoxycarbonyl)pyridin-3-yl)piperazine-1-carboxylate | 1354355-85-3 | C16H23N3O4 |
|
| 4-(4-羧基苯基)哌嗪-1-羧酸叔丁酯 | 4-(4-(tert-butoxycarbonyl)piperazin-1-yl)benzoic acid | 162046-66-4 | C16H22N2O4 |
|
| 4-(4-硝基苯基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate | 182618-86-6 | C15H21N3O4 |
|
| 4-(4-甲基哌嗪-1-基甲基)苯胺 | 4-[(4-methyl-1-piperazinyl)methyl]aniline | 70261-82-4 | C12H19N3 |
|
| 4-(4-甲基哌嗪-1-基)苯甲腈 | 4-(4-methylpiperazin-1-yl)benzonitrile | 34334-28-6 | C12H15N3 |
|
| 4-(4-甲基哌嗪-1-基)-2-硝基苯甲酸叔丁酯 | tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate | 942271-61-6 | C16H23N3O4 |
|
| 4-(4-甲基-哌嗪-1-基)-苯甲酸乙酯 | ethyl 4-(4-methylpiperazin-1-yl)benzoate | 773137-71-6 | C14H20N2O2 |
|
| 4-(4-甲基-1-哌嗪基)苯甲醇 | (4-(4-methylpiperazin-1-yl)phenyl)methanol | 342405-34-9 | C12H18N2O |
|
| 4-(4-甲基-1-哌嗪基)丁酸 | 4-(4-methyl-1-piperazinyl)butyric acid | 58077-68-2 | C9H18N2O2 |
|
| 4-(4-甲基-1-哌嗪基)-2-[(4-四氢吡喃基)(2,2,2-三氟乙酰基)氨基]苯甲酸三氟乙酸盐 | 4-(4-methylpiperazin-1-yl)-2-[tetrahydro-2H-pyran-4-yl-(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate | 1034975-62-6 | C2HF3O2*C19H24F3N3O4 |
|
| 4-(4-氨基苄基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(4-aminobenzyl)piperazine-1-carboxylate | 304897-49-2 | C16H25N3O2 |
|
| 4-(4-氨基-2-氰基苯基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate | 288251-85-4 | C16H22N4O2 |
|
| 4-(4-氨基-2-三氟甲基苯基)-哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate | 193902-87-3 | C16H22F3N3O2 |
|
| 4-(4-叔丁氧基羰酰)哌嗪甲基苯甲酸 | 4-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)benzoic acid | 479353-63-4 | C17H24N2O4 |
|
| 4-(4-乙基哌嗪-1-甲基)苄胺 | 4-(4-Ethylpiperazin-1-ylmethyl)benzylamine | 914349-67-0 | C14H23N3 |
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| 4-(4-乙基哌嗪-1-甲基)-苯胺 | 4-((4-ethylpiperazin-1-yl)methyl)aniline | 611225-86-6 | C13H21N3 |
|
| 4-(4-乙基哌嗪-1-基)苯胺 | 4-(4-ethylpiperazin-1-yl)aniline | 115619-01-7 | C12H19N3 |
|
| 4-(4-(4-甲基哌嗪-1-基)哌啶-1-基)苯胺 | 4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline | 959795-70-1 | C16H26N4 |
|
| 4-(3-甲酰基-4-羟基苯基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate | 343306-50-3 | C16H22N2O4 |
|
| 4-(3-氨基苯基)-1-哌嗪羧酸-1,1-二甲基乙酯 | tert-butyl 4-(3-aminophenyl)piperazine-1-carboxylate | 206879-72-3 | C15H23N3O2 |
|
| 4-(3-氨基丙基)-哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(3-aminopropyl)piperazine-1-carboxylate | 373608-48-1 | C12H25N3O2 |
|
| 4-(2-溴乙基)-1-哌嗪羧酸-1,1-二甲基乙酯 | tert-butyl 4-(2-bromoethyl)piperazine-1-carboxylate | 655225-01-7 | C11H21BrN2O2 |
|
| 4-(2-氯乙基)四氢-1(2H)-吡嗪羧酸叔丁酯 | tert-butyl 4-(2-chloroethyl)piperazine-1-carboxylate | 208167-83-3 | C11H21ClN2O2 |
|
| 4-(2-(甲基氨基)乙基)哌嗪-1-甲酸叔丁酯 | tert-butyl 4-(2-(methylamino)ethyl)piperazine-1-carboxylate | 539822-98-5 | C12H25N3O2 |
|
| 4-(1H-吲唑-3-基)哌嗪-1-甲酸叔丁酯 | tert-butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate | 947498-81-9 | C16H22N4O2 |
|
| 4-(1-哌嗪基)苯甲酸乙酯 | ethyl 4-(piperazin-1-yl)benzoate | 80518-57-6 | C13H18N2O2 |
|
| 4-(1-哌嗪基)-1H-吲哚 | 4-(1-piperazinyl)-1H-indole | 84807-09-0 | C12H15N3 |
|
| 4-((5r,7s)-7-羟基-5-甲基-6,7-二氢-5H-环戊并[d]嘧啶-4-基)哌嗪-1-羧酸叔丁酯 | tert-butyl 4-((5R,7S)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate | 1001201-61-1 | C17H26N4O3 |
|
| 4,4'-二氟苯甲哌嗪 | 1-(4-fluorophenyl)methyl-piperazine | 27469-60-9 | C17H18F2N2 |
|
| 3-碘-4-甲基-N-[4-[(4-甲基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]苯甲酰胺 | 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | 943320-50-1 | C21H23F3IN3O |
|
| 3-甲基-2-哌嗪-1-喹啉 | 3-methyl-2-piperazin-1-yl-quinoline | 348133-74-4 | C14H17N3 |
|
| 3-溴-7-氯-4-(1-哌嗪)喹啉 | 3-Bromo-7-chloro-4-(piperazin-1-yl)quinoline | 927801-09-0 | C13H13BrClN3 |
|
| 3-氧代-1-哌嗪羧酸叔丁酯 | 4-(t-butyloxycarbonyl)piperazin-2-one | 76003-29-7 | C9H16N2O3 |
|
| 3-哌嗪基丙酸甲酯 | 1-(2-methoxycarbonylethyl)piperazine | 43032-40-2 | C8H16N2O2 |
|
| 3-哌嗪-1,2-苯异唑 | 4(1,2-benzisoxazol-3-yl)piperazine | 87691-89-2 | C11H13N3O |
|
| 3-(哌嗪-1-基)丙酸乙酯 | ethyl 3-(piperazin-1-yl)propanoate | 43032-38-8 | C9H18N2O2 |
|
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