哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体,广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪,以及氟奋乃静、强痛定和利福平等其他药物。此外,这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂,以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。
哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶,具有温和的胺臭和咸味,并具备吸湿性。其相对密度为0.876,熔点为106.6℃,沸点为146℃。该化合物易溶于水和甘油,微溶于乙醇而不溶于乙醚。哌嗪具有强碱性,10%的水溶液pH值在10.8~11.8之间,并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用,具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物,是驱除蛔虫、蛲虫的有效药物,并用于有机合成。
哌嗪又称为“驱蛔灵”,对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹,防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象,相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病,亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%~80%,连续用药2天可提高治愈率。治疗蛲虫病需连续服药7~10天。该药物毒性较低,治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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N-肉桂基哌嗪 | 1-(3-phenyl-2-propenyl)piperazine | 18903-01-0 | C13H18N2 |
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N-甲基高哌嗪 | 1-Methylhomopiperazine | 4318-37-0 | C6H14N2 |
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N-甲基哌嗪 | 1-methyl-piperazine | 109-01-3 | C5H12N2 |
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N-氨乙基哌嗪 | aminoethylpiperazine | 140-31-8 | C6H15N3 |
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N-异丁基哌嗪 | 1-isobutylpiperazine | 5308-28-1 | C8H18N2 |
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N-哌嗪甲酸乙酯 | 4-ethoxycarbonylpiperazine | 120-43-4 | C7H14N2O2 |
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N-叔丁基哌嗪 | 1-(1,1-dimethylethyl)-piperazine | 38216-72-7 | C8H18N2 |
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N-乙氧羰基高哌嗪 | 1-ethoxycarbonyl-1,4-diazacycloheptane | 18739-39-4 | C8H16N2O2 |
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N-乙基哌嗪 | 4-ethylpiperazine | 5308-25-8 | C6H14N2 |
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N-[2-(1-哌嗪基)乙基]-1,2-乙二胺 | 1-<2-(2-aminoethyl)aminoethyl>piperazine | 24028-46-4 | C8H20N4 |
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N-Boc-哌嗪 | 1-t-Butoxycarbonylpiperazine | 57260-71-6 | C9H18N2O2 |
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N-4-苄氧羰基-2-哌嗪甲酸 | 4-((benzyloxy)carbonyl)piperazine-2-carboxylic acid | 64172-98-1 | C13H16N2O4 |
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N-4-Cbz-哌嗪-2-甲酸甲酯 | 1-benzyl 3-methyl piperazine-1,3-dicarboxylate | 129799-11-7 | C14H18N2O4 |
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N-4-BOC-2-哌嗪乙酸甲酯 | tert-butyl 3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate | 183742-33-8 | C12H22N2O4 |
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N-1-苄基-3-苯基哌嗪 | 1-benzyl-3-phenylpiperazine | 5368-32-1 | C17H20N2 |
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N-1-Boc-3-苄基哌嗪 | tert-butyl 3-benzylpiperazine-1-carboxylate | 502649-29-8 | C16H24N2O2 |
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N-(羟基甲基)哌嗪 | N-(hydroxymethyl)piperazine | 90324-69-9 | C5H12N2O |
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N-(ALPHA,ALPHA,ALPHA-三氟对甲苯)哌嗪 | 1-[4-(trifluoromethyl)phenyl]piperazine | 30459-17-7 | C11H13F3N2 |
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N-(3-氨基丙基)哌嗪 | 3-(piperazin-1-yl)propan-1-amine | 34885-02-4 | C7H17N3 |
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N-(2-氟苯基)哌嗪盐酸盐 | 1-(2-fluorophenyl)piperazine hydrochloride | 1011-16-1 | C10H13FN2*ClH |
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N-(1,4-苯并二烷-2-羰基)哌嗪 | (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone | 70918-00-2 | C13H16N2O3 |
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N,N’-二(3-羟基丙基)高哌嗪 | tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanol | 19970-80-0 | C11H24N2O2 |
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D-(-)-4-乙基-2,3-二氧-1-哌嗪酰胺基对羟基苯乙酸 | D-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino]-2-(4-hydroxyphenyl)-acetic acid | 79868-75-0 | C15H17N3O6 |
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BOC-2-甲基哌嗪甲酰氯 | tert-butyl (R)-4-(chlorocarbonyl)-3-methylpiperazine-1-carboxylate | 438050-54-5 | C11H19ClN2O3 |
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8-溴-2-(哌嗪-1-基)喹啉 | 8-bromo-2-piperazin-1-yl-quinoline | 348133-70-0 | C13H14BrN3 |
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7-氯-4-(1-哌嗪基)喹啉 | 7-chloro-4-piperazinylquinoline | 837-52-5 | C13H14ClN3 |
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6-碘-2-哌嗪-1-基-喹啉 | 6-Iodo-2-piperazin-1-yl-quinoline | 296759-25-6 | C13H14IN3 |
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6-甲氧基-吡嗪-2-硫代甲酰胺 | 6-methoxy-pyrazine-2-carbothioic acid amide | 68450-42-0 | C6H7N3OS |
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6-溴-2-哌嗪-1-基-喹啉 | 6-bromo-2-(piperazin-1-yl)quinoline | 124782-95-2 | C13H14BrN3 |
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6-氯-2-哌嗪-1-喹啉 | 6-chloro-2-piperazin-1-yl-quinoline | 78060-46-5 | C13H14ClN3 |
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6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯 | ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-<1,3>thiazeto<3,2-a>quinoline-3-carboxylate | 113028-17-4 | C18H20FN3O3S |
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6-(哌嗪-1-基)-4-氯嘧啶 | 4-chloro-6-piperazin-1-yl-pyrimidine | 373356-50-4 | C8H11ClN4 |
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5-碘-2-(哌嗪-1-基)嘧啶 | 5-iodo-2-(piperazin-1-yl)pyrimidine | 95847-41-9 | C8H11IN4 |
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5-溴-2-(4-boc-哌嗪-1-基)嘧啶 | tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate | 374930-88-8 | C13H19BrN4O2 |
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5-氨基-2-(4-甲基哌嗪-1-基)苯甲腈 | 5-amino-2-(4-methylpiperazin-1-yl)benzonitrile | 288251-82-1 | C12H16N4 |
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5-氧代-2-哌嗪羧酸 | 5-oxopiperazine-2-carboxylic acid | 3262-59-7 | C5H8N2O3 |
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5-(哌嗪-1-基)嘧啶 | N-(4-pyrimidyl)piperazine | 202135-70-4 | C8H12N4 |
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5-(4-甲基哌嗪)-2-硝基苯胺 | 5-(4-methylpiperazine-1-yl)-2-nitroaniline | 23491-48-7 | C11H16N4O2 |
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4H-吡唑[1,2-A]吡嗪-4-八氢酮 | octahydro-pyrido[1,2-<i>a</i>]pyrazin-4-one | 109814-50-8 | C8H14N2O |
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4-苄基哌嗪-2-酮 | 4-benzyl-piperazin-2-one | 13754-41-1 | C11H14N2O |
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4-苄基-3-氧代哌嗪-1-羧酸叔丁酯 | tert-butyl 4-benzyl-3-oxopiperazine-1-carboxylate | 78551-60-7 | C16H22N2O3 |
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4-甲基哌嗪-1-甲酰氯盐酸盐 | 4-methylpiperazine-1-carbonyl chloride monohydrochloride | 55112-42-0 | C6H11ClN2O*ClH |
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4-甲基-2-(1-哌嗪基)嘧啶 | 1-(4-methyl-pyrimidin-2-yl)piperazine | 59215-36-0 | C9H14N4 |
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4-甲基-2-(1-哌嗪基)喹啉 | 4-methyl-2-(piperazin-1-yl)quinoline | 50693-78-2 | C14H17N3 |
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4-甲基-1-哌嗪乙胺 | 2-(4-methylpiperazin-1-yl)ethylamine | 934-98-5 | C7H17N3 |
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4-氰基-4-苯基哌嗪 | 4-cyano-4-phenylpiperidine hydrochloride | 51304-58-6 | C12H14N2*ClH |
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4-氯羰基-哌嗪-1-羧酸叔丁酯 | tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate | 59878-28-3 | C10H17ClN2O3 |
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4-哌嗪苯甲酸 | 4-piperidin-1-yl-benzoic acid | 22090-24-0 | C12H15NO2 |
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4-哌嗪苯乙酮 | 4'-piperazinoacetophenone | 51639-48-6 | C12H16N2O |
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4-哌嗪基苯胺 | 4-(piperazin-1-yl)aniline | 67455-41-8 | C10H15N3 |
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