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哌嗪类化合物

哌嗪类化合物是指含有哌嗪结构的一类重要医药中间体,广泛应用于生产驱肠虫药物如磷酸哌嗪和枸橼酸哌嗪,以及氟奋乃静、强痛定和利福平等其他药物。此外,这些化合物也被用于制造湿润剂、乳化剂、分散剂等表面活性剂,以及抗氧剂、防腐剂、稳定剂等塑料加工助剂与橡胶助剂。

哌嗪又名六氢吡嗪或二亚乙基二胺。从乙醇中析出的哌嗪为白色斜方晶系叶片状结晶,具有温和的胺臭和咸味,并具备吸湿性。其相对密度为0.876,熔点为106.6℃,沸点为146℃。该化合物易溶于水和甘油,微溶于乙醇而不溶于乙醚。哌嗪具有强碱性,10%的水溶液pH值在10.8~11.8之间,并能吸收空气中的二氧化碳。对眼睛和皮肤有刺激作用,具有典型的仲胺反应。它可通过乙二胺与1,2-二氯乙烷反应或由氨基乙醇高温下二聚而制得。无机酸及有机酸盐用作人和动物的驱肠虫药物,是驱除蛔虫、蛲虫的有效药物,并用于有机合成。

哌嗪又称为“驱蛔灵”,对蛔虫和蛲虫均有较强作用。该药能使虫体肌肉发生松弛性麻痹,防止其随肠道蠕动被排出体外。使用时不会出现兴奋现象,相对安全。可用于治疗由蛔虫引起的不完全肠梗阻及早期胆道蛔虫病,亦适用于伴有溃疡病的患者。一般剂量治愈率可达70%~80%,连续用药2天可提高治愈率。治疗蛲虫病需连续服药7~10天。该药物毒性较低,治疗量下偶尔会出现恶心、呕吐或荨麻疹等副作用。

中文名称 英文名称 CAS号 化学式 结构式图片
N-肉桂基哌嗪 1-(3-phenyl-2-propenyl)piperazine 18903-01-0 C13H18N2
N-肉桂基哌嗪
N-甲基高哌嗪 1-Methylhomopiperazine 4318-37-0 C6H14N2
N-甲基高哌嗪
N-甲基哌嗪 1-methyl-piperazine 109-01-3 C5H12N2
N-甲基哌嗪
N-氨乙基哌嗪 aminoethylpiperazine 140-31-8 C6H15N3
N-氨乙基哌嗪
N-异丁基哌嗪 1-isobutylpiperazine 5308-28-1 C8H18N2
N-异丁基哌嗪
N-哌嗪甲酸乙酯 4-ethoxycarbonylpiperazine 120-43-4 C7H14N2O2
N-哌嗪甲酸乙酯
N-叔丁基哌嗪 1-(1,1-dimethylethyl)-piperazine 38216-72-7 C8H18N2
N-叔丁基哌嗪
N-乙氧羰基高哌嗪 1-ethoxycarbonyl-1,4-diazacycloheptane 18739-39-4 C8H16N2O2
N-乙氧羰基高哌嗪
N-乙基哌嗪 4-ethylpiperazine 5308-25-8 C6H14N2
N-乙基哌嗪
N-[2-(1-哌嗪基)乙基]-1,2-乙二胺 1-<2-(2-aminoethyl)aminoethyl>piperazine 24028-46-4 C8H20N4
N-[2-(1-哌嗪基)乙基]-1,2-乙二胺
N-Boc-哌嗪 1-t-Butoxycarbonylpiperazine 57260-71-6 C9H18N2O2
N-Boc-哌嗪
N-4-苄氧羰基-2-哌嗪甲酸 4-((benzyloxy)carbonyl)piperazine-2-carboxylic acid 64172-98-1 C13H16N2O4
N-4-苄氧羰基-2-哌嗪甲酸
N-4-Cbz-哌嗪-2-甲酸甲酯 1-benzyl 3-methyl piperazine-1,3-dicarboxylate 129799-11-7 C14H18N2O4
N-4-Cbz-哌嗪-2-甲酸甲酯
N-4-BOC-2-哌嗪乙酸甲酯 tert-butyl 3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate 183742-33-8 C12H22N2O4
N-4-BOC-2-哌嗪乙酸甲酯
N-1-苄基-3-苯基哌嗪 1-benzyl-3-phenylpiperazine 5368-32-1 C17H20N2
N-1-苄基-3-苯基哌嗪
N-1-Boc-3-苄基哌嗪 tert-butyl 3-benzylpiperazine-1-carboxylate 502649-29-8 C16H24N2O2
N-1-Boc-3-苄基哌嗪
N-(羟基甲基)哌嗪 N-(hydroxymethyl)piperazine 90324-69-9 C5H12N2O
N-(羟基甲基)哌嗪
N-(ALPHA,ALPHA,ALPHA-三氟对甲苯)哌嗪 1-[4-(trifluoromethyl)phenyl]piperazine 30459-17-7 C11H13F3N2
N-(ALPHA,ALPHA,ALPHA-三氟对甲苯)哌嗪
N-(3-氨基丙基)哌嗪 3-(piperazin-1-yl)propan-1-amine 34885-02-4 C7H17N3
N-(3-氨基丙基)哌嗪
N-(2-氟苯基)哌嗪盐酸盐 1-(2-fluorophenyl)piperazine hydrochloride 1011-16-1 C10H13FN2*ClH
N-(2-氟苯基)哌嗪盐酸盐
N-(1,4-苯并二烷-2-羰基)哌嗪 (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(piperazin-1-yl)methanone 70918-00-2 C13H16N2O3
N-(1,4-苯并二烷-2-羰基)哌嗪
N,N’-二(3-羟基丙基)高哌嗪 tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanol 19970-80-0 C11H24N2O2
N,N’-二(3-羟基丙基)高哌嗪
D-(-)-4-乙基-2,3-二氧-1-哌嗪酰胺基对羟基苯乙酸 D-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonylamino]-2-(4-hydroxyphenyl)-acetic acid 79868-75-0 C15H17N3O6
D-(-)-4-乙基-2,3-二氧-1-哌嗪酰胺基对羟基苯乙酸
BOC-2-甲基哌嗪甲酰氯 tert-butyl (R)-4-(chlorocarbonyl)-3-methylpiperazine-1-carboxylate 438050-54-5 C11H19ClN2O3
BOC-2-甲基哌嗪甲酰氯
8-溴-2-(哌嗪-1-基)喹啉 8-bromo-2-piperazin-1-yl-quinoline 348133-70-0 C13H14BrN3
8-溴-2-(哌嗪-1-基)喹啉
7-氯-4-(1-哌嗪基)喹啉 7-chloro-4-piperazinylquinoline 837-52-5 C13H14ClN3
7-氯-4-(1-哌嗪基)喹啉
6-碘-2-哌嗪-1-基-喹啉 6-Iodo-2-piperazin-1-yl-quinoline 296759-25-6 C13H14IN3
6-碘-2-哌嗪-1-基-喹啉
6-甲氧基-吡嗪-2-硫代甲酰胺 6-methoxy-pyrazine-2-carbothioic acid amide 68450-42-0 C6H7N3OS
6-甲氧基-吡嗪-2-硫代甲酰胺
6-溴-2-哌嗪-1-基-喹啉 6-bromo-2-(piperazin-1-yl)quinoline 124782-95-2 C13H14BrN3
6-溴-2-哌嗪-1-基-喹啉
6-氯-2-哌嗪-1-喹啉 6-chloro-2-piperazin-1-yl-quinoline 78060-46-5 C13H14ClN3
6-氯-2-哌嗪-1-喹啉
6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯 ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-<1,3>thiazeto<3,2-a>quinoline-3-carboxylate 113028-17-4 C18H20FN3O3S
6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯
6-(哌嗪-1-基)-4-氯嘧啶 4-chloro-6-piperazin-1-yl-pyrimidine 373356-50-4 C8H11ClN4
6-(哌嗪-1-基)-4-氯嘧啶
5-碘-2-(哌嗪-1-基)嘧啶 5-iodo-2-(piperazin-1-yl)pyrimidine 95847-41-9 C8H11IN4
5-碘-2-(哌嗪-1-基)嘧啶
5-溴-2-(4-boc-哌嗪-1-基)嘧啶 tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate 374930-88-8 C13H19BrN4O2
5-溴-2-(4-boc-哌嗪-1-基)嘧啶
5-氨基-2-(4-甲基哌嗪-1-基)苯甲腈 5-amino-2-(4-methylpiperazin-1-yl)benzonitrile 288251-82-1 C12H16N4
5-氨基-2-(4-甲基哌嗪-1-基)苯甲腈
5-氧代-2-哌嗪羧酸 5-oxopiperazine-2-carboxylic acid 3262-59-7 C5H8N2O3
5-氧代-2-哌嗪羧酸
5-(哌嗪-1-基)嘧啶 N-(4-pyrimidyl)piperazine 202135-70-4 C8H12N4
5-(哌嗪-1-基)嘧啶
5-(4-甲基哌嗪)-2-硝基苯胺 5-(4-methylpiperazine-1-yl)-2-nitroaniline 23491-48-7 C11H16N4O2
5-(4-甲基哌嗪)-2-硝基苯胺
4H-吡唑[1,2-A]吡嗪-4-八氢酮 octahydro-pyrido[1,2-<i>a</i>]pyrazin-4-one 109814-50-8 C8H14N2O
4H-吡唑[1,2-A]吡嗪-4-八氢酮
4-苄基哌嗪-2-酮 4-benzyl-piperazin-2-one 13754-41-1 C11H14N2O
4-苄基哌嗪-2-酮
4-苄基-3-氧代哌嗪-1-羧酸叔丁酯 tert-butyl 4-benzyl-3-oxopiperazine-1-carboxylate 78551-60-7 C16H22N2O3
4-苄基-3-氧代哌嗪-1-羧酸叔丁酯
4-甲基哌嗪-1-甲酰氯盐酸盐 4-methylpiperazine-1-carbonyl chloride monohydrochloride 55112-42-0 C6H11ClN2O*ClH
4-甲基哌嗪-1-甲酰氯盐酸盐
4-甲基-2-(1-哌嗪基)嘧啶 1-(4-methyl-pyrimidin-2-yl)piperazine 59215-36-0 C9H14N4
4-甲基-2-(1-哌嗪基)嘧啶
4-甲基-2-(1-哌嗪基)喹啉 4-methyl-2-(piperazin-1-yl)quinoline 50693-78-2 C14H17N3
4-甲基-2-(1-哌嗪基)喹啉
4-甲基-1-哌嗪乙胺 2-(4-methylpiperazin-1-yl)ethylamine 934-98-5 C7H17N3
4-甲基-1-哌嗪乙胺
4-氰基-4-苯基哌嗪 4-cyano-4-phenylpiperidine hydrochloride 51304-58-6 C12H14N2*ClH
4-氰基-4-苯基哌嗪
4-氯羰基-哌嗪-1-羧酸叔丁酯 tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate 59878-28-3 C10H17ClN2O3
4-氯羰基-哌嗪-1-羧酸叔丁酯
4-哌嗪苯甲酸 4-piperidin-1-yl-benzoic acid 22090-24-0 C12H15NO2
4-哌嗪苯甲酸
4-哌嗪苯乙酮 4'-piperazinoacetophenone 51639-48-6 C12H16N2O
4-哌嗪苯乙酮
4-哌嗪基苯胺 4-(piperazin-1-yl)aniline 67455-41-8 C10H15N3
4-哌嗪基苯胺