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    首页 分子通 按分子结构分类 有机化合物 有机杂环化合物 吡啶及其衍生物

    吡啶及其衍生物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (3R)-N-{5-chloro-4-[3-(3-fluorobenzyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyridin-2-yl}piperidine-3-carboxamide —— C25H23ClFN5O2
    (3R)-N-{5-chloro-4-[3-(3-fluorobenzyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]pyridin-2-yl}piperidine-3-carboxamide
    —— US9650358, Example 103 —— C27H27ClFN5O2
    US9650358, Example 103
    —— US9650358, Example 120 —— C32H31ClFN5O
    US9650358, Example 120
    —— (S)-tert-butyl 4-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-6-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate —— C25H28FN3O4
    (S)-tert-butyl 4-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-6-(hydroxymethyl)-5,6-dihydropyridine-1(2H)-carboxylate
    —— US9650358, Example 96 —— C26H27ClFN5
    US9650358, Example 96
    —— 2-[(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide —— C24H27FN4O3
    2-[(2S)-4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide
    —— US9650358, Example 282 —— C26H31ClN4O5S
    US9650358, Example 282
    —— US9650358, Example 46 —— C25H27ClFN5
    US9650358, Example 46
    —— (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2,2,1]heptan-2-yl)methanone —— C21H19F3N6O2
    (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2,2,1]heptan-2-yl)methanone
    —— US9650358, Example 203 —— C29H29ClFN5O3S
    US9650358, Example 203
    —— (3S,5R)-5-[[[5-chloro-6-(2-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl]amino]methyl]pyrrolidin-3-ol —— C22H27ClN6O
    (3S,5R)-5-[[[5-chloro-6-(2-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl]amino]methyl]pyrrolidin-3-ol
    —— tert-butyl 2-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)morpholine-4-carboxylate —— C23H26FN3O4
    tert-butyl 2-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)morpholine-4-carboxylate
    —— 4-[(1R)-1-[(2-methylpropan-2-yl)oxy]ethyl]-3-[2-[[(1S)-1-[5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one —— C27H30F3N5O3
    4-[(1R)-1-[(2-methylpropan-2-yl)oxy]ethyl]-3-[2-[[(1S)-1-[5-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
    —— (6-Methyl-3-pyrrolidin-1-ylpyridin-2-yl)-[2-(pyridin-2-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone —— C23H28N4O2
    (6-Methyl-3-pyrrolidin-1-ylpyridin-2-yl)-[2-(pyridin-2-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone
    —— US9650358, Example 86 —— C31H33ClFN5
    US9650358, Example 86
    —— US9650358, Example 290 —— C25H31ClN6O4S
    US9650358, Example 290
    —— tert-butyl 3-(4-(3-chloro-6-(((5-fluoropyridin-3-yl)methyl)amino)pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-carboxylate —— C28H30ClFN6O2
    tert-butyl 3-(4-(3-chloro-6-(((5-fluoropyridin-3-yl)methyl)amino)pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-carboxylate
    —— 2-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-5,5-dioxo-2-N-phenyl-5lambda6-thia-2-azaspiro[3.4]octane-2,8-dicarboxamide —— C33H28ClFN6O4S
    2-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-5,5-dioxo-2-N-phenyl-5lambda6-thia-2-azaspiro[3.4]octane-2,8-dicarboxamide
    —— tert-butyl 2-(4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,5-dimethylmorpholine-4-carboxylate —— C25H30FN3O4
    tert-butyl 2-(4-(4-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,5-dimethylmorpholine-4-carboxylate
    —— 4-(5-fluoro-2-methoxyphenyl)-2-(1-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile —— C27H30FN5O3
    4-(5-fluoro-2-methoxyphenyl)-2-(1-{2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethyl}piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile
    —— (1S,5R,6S)-5-(6-bromo-3-fluoropyridin-2-yl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine —— C11H9BrF3N3O
    (1S,5R,6S)-5-(6-bromo-3-fluoropyridin-2-yl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
    —— [2-[(6-Methylpyridin-2-yl)oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]-[6-methyl-3-(triazol-2-yl)pyridin-2-yl]methanone —— C22H24N6O2
    [2-[(6-Methylpyridin-2-yl)oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]-[6-methyl-3-(triazol-2-yl)pyridin-2-yl]methanone
    —— US9650358, Example 177 —— C26H31ClN6O3
    US9650358, Example 177
    —— US9650358, Example 169 —— C27H28ClN5O3
    US9650358, Example 169
    —— (3R)-N-[5-chloro-4-(1-{3-[(4-methylpiperazin-1-yl)methyl]benzyl}-1H-benzotriazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide —— C30H35ClN8O
    (3R)-N-[5-chloro-4-(1-{3-[(4-methylpiperazin-1-yl)methyl]benzyl}-1H-benzotriazol-6-yl)pyridin-2-yl]piperidine-3-carboxamide
    —— [(1S,8R)-5-(5-fluoro-6-methylpyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-fluoro-3-(trifluoromethyl)phenyl]methanone —— C21H16F5N5O2
    [(1S,8R)-5-(5-fluoro-6-methylpyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-fluoro-3-(trifluoromethyl)phenyl]methanone
    —— (3R)-N-[4-(1-{2-[bis(2-hydroxyethyl)amino]ethyl}-1H-benzotriazol-6-yl)-5-chloropyridin-2-yl]piperidine-3-carboxamide —— C23H30ClN7O3
    (3R)-N-[4-(1-{2-[bis(2-hydroxyethyl)amino]ethyl}-1H-benzotriazol-6-yl)-5-chloropyridin-2-yl]piperidine-3-carboxamide
    —— 2-[[5-Chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-(dimethylsulfamoyl)amino]acetamide —— C23H22ClFN6O3S
    2-[[5-Chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-(dimethylsulfamoyl)amino]acetamide
    —— [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,6R)-6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azabicyclo[2.2.1]heptan-2-yl]methanone —— C20H18F3N7O2
    [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,6R)-6-[5-(trifluoromethyl)pyrazin-2-yl]oxy-2-azabicyclo[2.2.1]heptan-2-yl]methanone
    —— (+/-)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(2-((pyridazin-3-yloxy)methyl)-7-azabicyclo[2.2.1]heptan-7-yl)methanone —— C20H21N7O2
    (+/-)-(6-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)(2-((pyridazin-3-yloxy)methyl)-7-azabicyclo[2.2.1]heptan-7-yl)methanone
    —— [2-chloro-3-(trifluoromethyl)phenyl]-[(1S,8R)-5-(5-fluoro-4-methoxypyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone;(2,3-dichloro-4-fluorophenyl)-[(1S,8R)-5-(5-fluoro-4-methoxypyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone;(2,3-dichlorophenyl)-[(1S,8R)-5-pyridin-2-yl-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone —— C60H46Cl5F6N15O8
    [2-chloro-3-(trifluoromethyl)phenyl]-[(1S,8R)-5-(5-fluoro-4-methoxypyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone;(2,3-dichloro-4-fluorophenyl)-[(1S,8R)-5-(5-fluoro-4-methoxypyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone;(2,3-dichlorophenyl)-[(1S,8R)-5-pyridin-2-yl-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone
    —— 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile —— C21H18F2N4O3S
    5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-[1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
    —— US9650358, Example 175 —— C26H34ClN5O
    US9650358, Example 175
    —— 2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-N-(2-hydroxyethyl)-N-methylacetamide —— C26H29FN4O3
    2-{3-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-8-azabicyclo[3.2.1]oct-2-en-8-yl}-N-(2-hydroxyethyl)-N-methylacetamide
    —— US9650358, Example 302 —— C26H30ClN5O4S
    US9650358, Example 302
    —— (3R)-N-{5-chloro-4-[2-(3-fluorobenzyl)-1-methyl-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide —— C26H25ClFN5O
    (3R)-N-{5-chloro-4-[2-(3-fluorobenzyl)-1-methyl-1H-benzimidazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide
    —— 2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethylacetamide —— C24H26FN5O2
    2-{4-[5-cyano-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-N,N-dimethylacetamide
    —— 1-Pyridin-2-ylbut-1-en-2-ylphosphane —— C9H12NP
    1-Pyridin-2-ylbut-1-en-2-ylphosphane
    —— (2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone —— C20H15Cl2F2N5O3
    (2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(5-fluoro-4-methoxypyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone
    —— [6-Methyl-2-(triazol-1-yl)pyridin-3-yl]-[2-[[6-(trifluoromethyl)pyridin-2-yl]oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]methanone —— C22H21F3N6O2
    [6-Methyl-2-(triazol-1-yl)pyridin-3-yl]-[2-[[6-(trifluoromethyl)pyridin-2-yl]oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]methanone
    —— 4-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-4-N-(2-morpholin-4-ylethyl)cyclohexane-1,4-diamine —— C31H36ClFN6O
    4-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-4-N-(2-morpholin-4-ylethyl)cyclohexane-1,4-diamine
    —— 4-(4-fluoro-2-methoxyphenyl)-2-pyrrolidin-3-yl-1H-pyrrolo[2,3-b]pyridine —— C18H18FN3O
    4-(4-fluoro-2-methoxyphenyl)-2-pyrrolidin-3-yl-1H-pyrrolo[2,3-b]pyridine
    —— [2-[(5-Fluoropyrimidin-2-yl)oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]-(6-methyl-3-pyrazol-1-ylpyridin-2-yl)methanone —— C21H21FN6O2
    [2-[(5-Fluoropyrimidin-2-yl)oxymethyl]-7-azabicyclo[2.2.1]heptan-7-yl]-(6-methyl-3-pyrazol-1-ylpyridin-2-yl)methanone
    —— tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydro-2H-pyridine-1-carboxylate —— C25H28FN3O3
    tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-6-methyl-3,6-dihydro-2H-pyridine-1-carboxylate
    —— 2-(azepan-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine —— C20H22FN3O
    2-(azepan-3-yl)-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine
    —— US9650358, Example 199 —— C34H35ClFN5O4S
    US9650358, Example 199
    —— 1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-2-(4-hydroxypiperidin-1-yl)ethanone trifluoroacetate —— C26H31FN4O3
    1-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]piperidin-1-yl}-2-(4-hydroxypiperidin-1-yl)ethanone trifluoroacetate
    —— [6-Methyl-3-(triazol-2-yl)pyridin-2-yl]-[2-(pyridin-4-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone —— C21H22N6O2
    [6-Methyl-3-(triazol-2-yl)pyridin-2-yl]-[2-(pyridin-4-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone
    —— US9650358, Example 245 —— C29H33ClFN5O
    US9650358, Example 245
    —— US9650358, Example 190 —— C27H22ClFN4O2
    US9650358, Example 190