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    首页 分子通 按分子结构分类 有机化合物 有机杂环化合物 吡啶及其衍生物

    吡啶及其衍生物

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [(1S,8R)-5-[4-(difluoromethoxy)pyridin-2-yl]-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-methyl-3-(trifluoromethyl)phenyl]methanone —— C22H18F5N5O3
    [(1S,8R)-5-[4-(difluoromethoxy)pyridin-2-yl]-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-methyl-3-(trifluoromethyl)phenyl]methanone
    —— 3-[2-[[(1S)-1-[2,5-difluoro-4-(2-methylpyridin-4-yl)phenyl]ethyl]amino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one —— C23H23F2N5O3
    3-[2-[[(1S)-1-[2,5-difluoro-4-(2-methylpyridin-4-yl)phenyl]ethyl]amino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one
    —— methyl 4-amino-5,6′-dichloro-3-fluoro-[2,3′-bipyridine]-6-carboxylate —— C12H8Cl2FN3O2
    methyl 4-amino-5,6′-dichloro-3-fluoro-[2,3′-bipyridine]-6-carboxylate
    —— 2-methoxy-3-(1-methyl-1H-pyrazol-4-yl)-5-(1H-1,2,4-triazol-1-ylmethyl)pyridine —— C13H14N6O
    2-methoxy-3-(1-methyl-1H-pyrazol-4-yl)-5-(1H-1,2,4-triazol-1-ylmethyl)pyridine
    —— 2,2-Dimethyl-3-[5-(quinolin-2-ylmethoxy)-1-[[4-[6-(trifluoromethyl)pyridin-3-yl]phenyl]methyl]benzimidazol-2-yl]propanoic acid —— C35H29F3N4O3
    2,2-Dimethyl-3-[5-(quinolin-2-ylmethoxy)-1-[[4-[6-(trifluoromethyl)pyridin-3-yl]phenyl]methyl]benzimidazol-2-yl]propanoic acid
    —— [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,4R,6R)-6-[5-(trifluoromethyl)pyrimidin-2-yl]oxy-2-azabicyclo[2.2.2]octan-2-yl]methanone —— C21H20F3N7O2
    [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,4R,6R)-6-[5-(trifluoromethyl)pyrimidin-2-yl]oxy-2-azabicyclo[2.2.2]octan-2-yl]methanone
    —— N-(6-((1S,5R,6S)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-5-fluoropyridin-2-yl)-5-cyanopicolinamide —— C18H15FN6O2
    N-(6-((1S,5R,6S)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-5-fluoropyridin-2-yl)-5-cyanopicolinamide
    —— [(1S,8R)-5-(3-fluoropyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-methyl-3-(trifluoromethyl)phenyl]methanone —— C21H17F4N5O2
    [(1S,8R)-5-(3-fluoropyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-methyl-3-(trifluoromethyl)phenyl]methanone
    —— US9650358, Example 329 —— C24H27ClFN5O2
    US9650358, Example 329
    —— (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone —— C20H19F3N8O
    (6-methyl-2-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone
    —— (2,3-dichlorophenyl)-[(1S,8R)-5-[4-(difluoromethoxy)pyridin-2-yl]-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone —— C20H15Cl2F2N5O3
    (2,3-dichlorophenyl)-[(1S,8R)-5-[4-(difluoromethoxy)pyridin-2-yl]-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone
    —— [3-Chloro-2-(trifluoromethyl)pyridin-4-yl]-(5-pyridin-2-yl-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl)methanone —— C20H16ClF3N6O
    [3-Chloro-2-(trifluoromethyl)pyridin-4-yl]-(5-pyridin-2-yl-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl)methanone
    —— US9650358, Example 122 —— C27H27ClFN5
    US9650358, Example 122
    —— 2-(4-{[5-(3-chlorophenyl)-6-methoxypyridin-3-yl]methyl}phenyl)propan-2-ol —— C22H22ClNO2
    2-(4-{[5-(3-chlorophenyl)-6-methoxypyridin-3-yl]methyl}phenyl)propan-2-ol
    —— 3-[2-(difluoromethoxy)pyridin-4-yl]-5-{[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]methyl}-2-methoxypyridine —— C16H13F4N5O2
    3-[2-(difluoromethoxy)pyridin-4-yl]-5-{[3-(difluoromethyl)-1H-1,2,4-triazol-1-yl]methyl}-2-methoxypyridine
    —— 3-[2-(difluoromethoxy)pyridin-4-yl]-5-{[3-(fluoromethyl)-1H-1,2,4-triazol-1-yl]methyl}-2-methoxypyridine —— C16H14F3N5O2
    3-[2-(difluoromethoxy)pyridin-4-yl]-5-{[3-(fluoromethyl)-1H-1,2,4-triazol-1-yl]methyl}-2-methoxypyridine
    —— 3-(3-chlorophenyl)-5-(dibromomethyl)-2-(difluoromethoxy)pyridine —— C13H8Br2ClF2NO
    3-(3-chlorophenyl)-5-(dibromomethyl)-2-(difluoromethoxy)pyridine
    —— 2-{[5-(3-chlorophenyl)-6-(difluoromethoxy)pyridin-3-yl]methyl}pyrazine —— C17H12ClF2N3O
    2-{[5-(3-chlorophenyl)-6-(difluoromethoxy)pyridin-3-yl]methyl}pyrazine
    —— US9650358, Example 202 —— C34H29ClFN5O4S
    US9650358, Example 202
    —— (4R)-4-[(1R)-1-[(2-methylpropan-2-yl)oxy]ethyl]-3-[2-[[(1S)-1-[5-[6-(trifluoromethyl)pyridin-2-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one —— C26H29F3N6O3
    (4R)-4-[(1R)-1-[(2-methylpropan-2-yl)oxy]ethyl]-3-[2-[[(1S)-1-[5-[6-(trifluoromethyl)pyridin-2-yl]pyridin-2-yl]ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
    —— N-[1-[[5-(3-chlorophenyl)-6-methoxypyridin-3-yl]methyl]pyrazol-4-yl]acetamide —— C18H17ClN4O2
    N-[1-[[5-(3-chlorophenyl)-6-methoxypyridin-3-yl]methyl]pyrazol-4-yl]acetamide
    —— tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydro-2H-pyridine-1-carboxylate —— C25H28FN3O4
    tert-butyl 4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-2-(hydroxymethyl)-3,6-dihydro-2H-pyridine-1-carboxylate
    —— 3-[3-(Difluoromethoxy)phenyl]-2-ethoxy-5-[[5-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]pyridine —— C18H15F5N4O2
    3-[3-(Difluoromethoxy)phenyl]-2-ethoxy-5-[[5-(trifluoromethyl)-1,2,4-triazol-1-yl]methyl]pyridine
    —— (2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone —— C20H13Cl2F4N5O3
    (2,3-dichloro-4-fluorophenyl)((6R,10S)-3-(4-(trifluoromethoxy)pyridin-2-yl)-6,7,9,10-tetrahydro-5H-6,10-epimino[1,2,4]triazolo[3,4-d][1,5]oxazocin-11-yl)methanone
    —— [1-({5-[3-(difluoromethoxy)phenyl]-6-ethoxypyridin-3-yl}methyl)-1H-1,2,4-triazol-3-yl]methanol —— C18H18F2N4O3
    [1-({5-[3-(difluoromethoxy)phenyl]-6-ethoxypyridin-3-yl}methyl)-1H-1,2,4-triazol-3-yl]methanol
    —— tert-butyl (1R,5S)-5-[2-fluoro-5-(5-fluoropyridin-3-yl)-4-[(4-methoxyphenyl)methoxymethyl]phenyl]-5-(fluoromethyl)-3-[(2-methylpropan-2-yl)oxycarbonylimino]-2-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate —— C36H40F3N3O7
    tert-butyl (1R,5S)-5-[2-fluoro-5-(5-fluoropyridin-3-yl)-4-[(4-methoxyphenyl)methoxymethyl]phenyl]-5-(fluoromethyl)-3-[(2-methylpropan-2-yl)oxycarbonylimino]-2-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate
    —— (5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2,2,1]heptan-2-yl)methanone —— C21H19F3N6O2
    (5-methyl-3-(2H-1,2,3-triazol-2-yl)pyridin-2-yl)((1S,4R,6R)-6-((5-(trifluoromethyl)pyridin-2-yl)oxy)-2-azabicyclo[2,2,1]heptan-2-yl)methanone
    —— 1-((5-(3-(difluoromethoxy)phenyl)-6-ethoxypyridin-3-yl)methyl)-1H-1,2,3-triazole-4-carbaldehyde —— C18H16F2N4O3
    1-((5-(3-(difluoromethoxy)phenyl)-6-ethoxypyridin-3-yl)methyl)-1H-1,2,3-triazole-4-carbaldehyde
    —— (6S,9R)-10-{[2-methyl-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine —— C21H18F3N5O
    (6S,9R)-10-{[2-methyl-3-(trifluoromethyl)phenyl]carbonyl}-3-pyridin-2-yl-6,7,8,9-tetrahydro-5H-6,9-epimino[1,2,4]triazolo[4,3-a]azepine
    —— US9650358, Example 335 —— C31H38ClN5O4
    US9650358, Example 335
    —— (3R)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-indazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide —— C25H23ClFN5O
    (3R)-N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-indazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide
    —— tert-butyl 4-(4-(4-chloro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-carboxylate —— C24H28ClN3O3
    tert-butyl 4-(4-(4-chloro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-carboxylate
    —— methyl 4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzimidazol-1-yl]methyl}benzoate —— C27H26ClN5O3
    methyl 4-{[6-(5-chloro-2-{[(3R)-piperidin-3-ylcarbonyl]amino}pyridin-4-yl)-1H-benzimidazol-1-yl]methyl}benzoate
    —— 6-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1H-pyrazol-3-ylmethyl)pyridin-2-amine —— C22H25N7
    6-[2-(1-methylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1H-pyrazol-3-ylmethyl)pyridin-2-amine
    —— US9650358, Example 252 —— C19H17ClF3N5O
    US9650358, Example 252
    —— US9650358, Example 278 —— C21H17ClFN5O3S
    US9650358, Example 278
    —— (2,3-dichloro-4-fluorophenyl)-[(1S,8R)-5-(6-methylpyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone —— C20H16Cl2FN5O2
    (2,3-dichloro-4-fluorophenyl)-[(1S,8R)-5-(6-methylpyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]methanone
    —— [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,4R,6R)-6-[5-(trifluoromethyl)pyridin-2-yl]oxy-2-azabicyclo[2.2.2]octan-2-yl]methanone —— C22H21F3N6O2
    [6-methyl-3-(triazol-2-yl)pyridin-2-yl]-[(1S,4R,6R)-6-[5-(trifluoromethyl)pyridin-2-yl]oxy-2-azabicyclo[2.2.2]octan-2-yl]methanone
    —— 6-(5-chloro-2-fluoropyridin-4-yl)-1-methyl-1H-benzo[d]imidazole —— C13H9ClFN3
    6-(5-chloro-2-fluoropyridin-4-yl)-1-methyl-1H-benzo[d]imidazole
    —— (6-methyl-3-morpholin-4-ylpyridin-2-yl)-[(1S,2R,4R)-2-(pyridin-2-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone —— C23H28N4O3
    (6-methyl-3-morpholin-4-ylpyridin-2-yl)-[(1S,2R,4R)-2-(pyridin-2-yloxymethyl)-7-azabicyclo[2.2.1]heptan-7-yl]methanone
    —— (1R,2S)-2-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-2-N-cyclopentylcyclobutane-1,2-dicarboxamide —— C30H29ClFN5O2
    (1R,2S)-2-N-[5-chloro-4-[3-[(3-fluorophenyl)methyl]benzimidazol-5-yl]pyridin-2-yl]-2-N-cyclopentylcyclobutane-1,2-dicarboxamide
    —— US9650358, Example 257 —— C23H23ClN6O2
    US9650358, Example 257
    —— N-[5-chloro-4-[3-(1,3-thiazol-4-ylmethyl)benzimidazol-5-yl]pyridin-2-yl]piperidine-3-carboxamide —— C22H21ClN6OS
    N-[5-chloro-4-[3-(1,3-thiazol-4-ylmethyl)benzimidazol-5-yl]pyridin-2-yl]piperidine-3-carboxamide
    —— 5-chloro-4-(1-((5-fluoropyridin-3-yl)methyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)pyridin-2-amine —— C18H13ClFN5
    5-chloro-4-(1-((5-fluoropyridin-3-yl)methyl)-1H-pyrrolo[3,2-b]pyridin-6-yl)pyridin-2-amine
    —— N-(6-((1R,5S,6R)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-5-fluoropyridin-2-yl)-5-cyanopicolinamide —— C18H15FN6O2
    N-(6-((1R,5S,6R)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-5-fluoropyridin-2-yl)-5-cyanopicolinamide
    —— 5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile —— C25H23F2N5O3
    5-fluoro-4-(5-fluoro-2-methoxyphenyl)-2-(1-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
    —— tert-butyl 4-(4-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)cyclohexanecarboxylate —— C30H36FN3O3
    tert-butyl 4-(4-(4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dihydropyridin-1(2H)-yl)cyclohexanecarboxylate
    —— trans-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine —— C24H30ClN5O
    trans-N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}cyclohexane-1,4-diamine
    —— [(1S,8R)-5-(3-fluoropyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-fluoro-3-(trifluoromethyl)phenyl]methanone —— C20H14F5N5O2
    [(1S,8R)-5-(3-fluoropyridin-2-yl)-10-oxa-3,4,6,12-tetrazatricyclo[6.3.1.02,6]dodeca-2,4-dien-12-yl]-[2-fluoro-3-(trifluoromethyl)phenyl]methanone
    —— US9650358, Example 182 —— C30H29ClFN5O2
    US9650358, Example 182