(S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methyl-butan-2-ol | 204253-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methyl-butan-2-ol
• CAS: 204253-45-2
• 化学式: C₂₆H₃₀O₄
• 分子量: 406.522
• InChiKey: JAJCMNKJSZOGBH-RUZDIDTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  30.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methyl-butan-2-ol 在 二乙胺 作用下， 以 二氯甲烷 为溶剂， 以71%的产率得到Diisopropyl-phosphoramidous acid (S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-methyl-propyl ester 2-cyano-ethyl ester
  参考文献：
  名称：

  Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone

  摘要：

  An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00064-x
• 作为产物：
  描述：

  L-α-羟基异戊酸 在 lithium aluminium tetrahydride 、 二乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-methyl-butan-2-ol
  参考文献：
  名称：

  Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone

  摘要：

  An unnatural biopolymer is described in which amino acid side-chains are presented along a negatively charged phosphodiester backbone. For this purpose, a series of phosphoramidite monomers was prepared from chiral 1,2-diols. These were efficiently converted into oligomers using standard coupling conditions on an automated DNA synthesizer. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00064-x