Methyl-N-methyl-5-hydroxynipecotinat | 38652-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl-N-methyl-5-hydroxynipecotinat
• 英文别名: 5-hydroxy-1-methyl-piperidine-3-carboxylic acid methyl ester；Methyl 5-hydroxy-1-methylpiperidine-3-carboxylate；methyl 5-hydroxy-1-methylpiperidine-3-carboxylate
• CAS: 38652-46-9
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: HMBRRPLNVQBQMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl-N-methyl-5-hydroxynipecotinat 在 盐酸 作用下， 生成 5-(di-thiophen-2-yl-methylene)-1-methyl-piperidin-3-ol
  参考文献：
  名称：

  5-羟基-3-哌啶亚基甲烷衍生物作为解痉剂。

  摘要：

  DOI：

  10.1021/jm00279a009

文献信息

• SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS
  申请人：DART NEUROSCIENCE (CAYMAN) LTD.

  公开号：US20170057967A1

  公开（公告）日：2017-03-02

  The invention provides a chemical entity of Formula (I) wherein R 1 , R 2 , X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
• US9932345B2
  申请人：——

  公开号：US9932345B2

  公开（公告）日：2018-04-03
• 5-Hydroxy-3-piperidylidenemethane derivatives as spasmolytics
  作者：Mitsutaka Kawazu、Takeshi Kanno、Seiichi Saito、Hajime Tamaki

  DOI：10.1021/jm00279a009

  日期：1972.9