2-isopropyl-5-methyl-4,5-dihydro-oxazole | 4694-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-isopropyl-5-methyl-4,5-dihydro-oxazole
• 英文别名: 5-Methyl-2-propan-2-yl-4,5-dihydro-1,3-oxazole
• CAS: 4694-82-0
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: HHHOZEACEJIGSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  马来酸酐 、 2-isopropyl-5-methyl-4,5-dihydro-oxazole 以 1,2-二氯乙烷 为溶剂， 生成 2,10,10-trimethyl-tetrahydro-7,9a-methano-oxazolo[2,3-b][1,3]oxazepine-5,8-dione
  参考文献：
  名称：

  Nehring,R.; Seeliger,W., Angewandte Chemie, 1970, vol. 82, p. 448 - 449

  摘要：

  DOI：
• 作为产物：
  描述：

  2-isopropyl-5-methyl-3-oxazolidine 在 氢氧化钾 、 sodium hypochlorite 作用下， 以 乙醇 、 水 为溶剂， 生成 2-isopropyl-5-methyl-4,5-dihydro-oxazole
  参考文献：
  名称：

  Novel synthesis of 3-oxazolines

  摘要：

  A series of new aliphatic 3-oxazolines was obtained in moderate to good yields via oxidation of the corresponding 1,3-oxazolidines by N-chlorination with sodium hypochlorite followed by elimination in basic medium. Some of the 3-oxazolines obtained present interesting properties in the field of fragrance chemistry. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01723-8

文献信息

• [EN] USE OF OXAZOLINES AS AROMA/FLAVOUR PRECURSORS<br/>[FR] UTILISATION D'OXAZOLINES COMME PRÉCURSEURS D'ARÔME/DE SAVEUR
  申请人：NESTEC SA

  公开号：WO2013143904A1

  公开（公告）日：2013-10-03

  The present invention relates to compounds based on an oxazoline moiety which liberate Strecker aldehydes under mild and controllable conditions. In addition the invention relates to food products comprising such compounds, and uses of such compounds.

  本发明涉及基于噁唑啉基团的化合物，该化合物在温和和可控条件下释放 Strecker 醛。此外，该发明涉及包含这种化合物的食品产品，以及这种化合物的用途。
• Use of oxazolines as aroma/flavour precursors
  申请人：Nestec S.A.

  公开号：EP2644602A1

  公开（公告）日：2013-10-02

  The present invention relates to compounds based on an oxazoline moiety which liberate Strecker aldehydes under mild and controllable conditions. In addition the invention relates to food products comprising such compounds, and uses of such compounds.

  本发明涉及基于噁唑烷基团的化合物，在温和和可控条件下释放Strecker醛的方法。此外，本发明涉及包含此类化合物的食品产品以及此类化合物的用途。
• Ruthenium-catalyzed synthesis of biaryl compounds in water
  申请人：CHICAGO DISCOVERY SOLUTIONS, LLC

  公开号：US10300471B2

  公开（公告）日：2019-05-28

  Using a [RuCl2(arene)]2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl2(arene)]2 and a formate source may be prepared in situ or isolated for later use.

  利用[RuCl2(arene)]2 复合物和甲酸盐源，在水中进行定向正交 C-H 插入和芳基-芳基偶联反应，可得到有助于制备生物活性分子和中间体的双芳基化合物。反应可在环境气氛中进行。由[RuCl2(arene)]2 和甲酸源制备的钌催化剂可就地制备或分离出来备用。
• USE OF OXAZOLINES AS AROMA/FLAVOUR PRECURSORS
  申请人：Nestec S.A.

  公开号：EP2831051A1

  公开（公告）日：2015-02-04
• INSULIN SENSITISERS AND METHODS OF TREATMENT
  申请人：Collier Gregory Royce

  公开号：US20110003740A1

  公开（公告）日：2011-01-06

  The present invention relates generally to the field of therapy. The invention particularly relates to insulin sensitisers and methods of regulating glucose homeostasis and to the therapeutic or prophylactic treatment of diseases and associated conditions, in which impaired glucose uptake due to insulin resistance is involved or implicated, such as diabetes, syndrome X, hyperglycaemia, vascular disease and kidney disease. The present invention further relates to compounds and agents and compositions thereof for use in the treatment methods.