4-[2-(4-甲基-1-哌啶基)-2-氧代-乙氧基]苯甲醛 | 915923-84-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-[2-(4-甲基-1-哌啶基)-2-氧代-乙氧基]苯甲醛
• 英文名称: 4-[2-(4-Methylpiperidin-1-yl)-2-oxoethoxy]benzaldehyde
• CAS: 915923-84-1
• 化学式: C₁₅H₁₉NO₃
• mdl: MFCD08575660
• 分子量: 261.321
• InChiKey: DNTDYMHMPZKSMA-UHFFFAOYSA-N

物化性质

• 沸点：
  461.8±25.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 4-[2-(4-甲基-1-哌啶基)-2-氧代-乙氧基]苯甲醛 在 三(五氟苯基)硼烷 、 叔丁基过氧化氢 作用下， 以 癸烷 为溶剂， 反应 24.25h， 以83%的产率得到methyl 4-(2-(4-methylpiperidin-1-yl)-2-oxoethoxy)benzoate
  参考文献：
  名称：

  An efficient one-pot oxidative esterification of aldehydes to carboxylic esters using B(C6F5)3–TBHP

  摘要：

  A simple and efficient protocol for oxidative esterification of diverse aldehydes with alcohols was accomplished with tert-butyl hydroperoxide and 1 mol % of tris(pentafluorophenyl)borane [B(C6F5)(3)] to generate the corresponding esters in good to excellent yields. The present protocol represents compatibility with wide range of functional groups as well as exceptional tolerance toward acid labile protecting groups such as TBDPS, TBDMS, acetonide, and Boc. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.033

文献信息

• An efficient one-pot oxidative esterification of aldehydes to carboxylic esters using B(C6F5)3–TBHP
  作者：Sravanthi Devi Guggilapu、Santosh Kumar Prajapti、Bathini Nagendra Babu

  DOI：10.1016/j.tetlet.2015.01.033

  日期：2015.2

  A simple and efficient protocol for oxidative esterification of diverse aldehydes with alcohols was accomplished with tert-butyl hydroperoxide and 1 mol % of tris(pentafluorophenyl)borane [B(C6F5)(3)] to generate the corresponding esters in good to excellent yields. The present protocol represents compatibility with wide range of functional groups as well as exceptional tolerance toward acid labile protecting groups such as TBDPS, TBDMS, acetonide, and Boc. (C) 2015 Elsevier Ltd. All rights reserved.