5-propyl-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole | 926893-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-propyl-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole
• 英文别名: 2-(4-phenylpiperazin-1-yl)-N-[(1-phenyl-5-propylpyrazol-3-yl)methyl]ethanamine
• CAS: 926893-85-8
• 化学式: C₂₅H₃₃N₅
• 分子量: 403.571
• InChiKey: QRZQIUITHSYJHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  36.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(4-苯基-哌嗪-1-基)-乙胺 、 5-Propyl-1-phenylpyrazole-3-carbaldehyde 生成 5-propyl-1-phenyl-3-[2-(4-phenylpiperazin-1-yl)ethyl]aminomethylpyrazole
  参考文献：
  名称：

  Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof

  摘要：

  本发明提供了新型哌嗪基烷基吡唑衍生物、其制备方法和选择性T型钙通道阻滞活性。特别地，本发明提供了一种由下列式表示的哌嗪基烷基吡唑衍生物或其药学上可接受的盐以及其制备方法。式1的化合物是一种新型哌嗪基烷基吡唑衍生物，特别具有T型Ca2+通道阻滞效应，因此可用作神经和肌肉疼痛的治疗剂。

  公开号：

  US07544686B2

文献信息

• USES, COMPOSITIONS AND METHODS
  申请人：Fisahn Andre

  公开号：US20210038589A1

  公开（公告）日：2021-02-11

  The present invention relates generally to calcium channel inhibitors for use in treating and/or preventing an amyloid disease of the nervous system. The invention also relates to related pharmaceutical compositions, kits and screening methods.
• T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF
  申请人：Praxis Precision Medicines, inc.

  公开号：US20210128537A1

  公开（公告）日：2021-05-06

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.
• US7544686B2
  申请人：——

  公开号：US7544686B2

  公开（公告）日：2009-06-09
• [EN] T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DE CANAL CALCIQUE DE TYPE T ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PRAXIS PREC MEDICINES INC

  公开号：WO2018118101A1

  公开（公告）日：2018-06-28

  Described herein are compounds useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy) and mood disorders. The present invention further comprises methods for modulating the function of a T-type calcium channel.