3-(4-nitrophenyl)-2,6-piperdidinedione-3-propionic acid | 42307-80-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(4-nitrophenyl)-2,6-piperdidinedione-3-propionic acid
• 英文别名: 3-<3-(4-nitrophenyl)-2,6,-dioxo-piperidin-3-yl>-propionic acid；3-<2,6-Dioxo-3-(4-nitrophenyl)-piperid-3-yl>-propionsaeure；3-[3-(4-nitro-phenyl)-2,6-dioxo-piperidin-3-yl]-propionic acid；3-[3-(4-nitrophenyl)-2,6-dioxopiperidin-3-yl]propanoic acid
• CAS: 42307-80-2
• 化学式: C₁₄H₁₄N₂O₆
• 分子量: 306.275
• InChiKey: HEPPIRDBSQQOIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(4-nitrophenyl)-2,6-piperdidinedione-3-propionic acid 在 Ra-Ni 氢气 作用下， 以 甲醇 为溶剂， 生成 3-[3-(4-Amino-phenyl)-2,6-dioxo-piperidin-3-yl]-N-sec-butyl-propionamide
  参考文献：
  名称：

  Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

  摘要：

  Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 & 31-35), tetrahydrofuranone (37) or tetraydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituents at positions 6 and 7 respectively (41) of the quinolone ring, are reported here, of these compounds on the in vitro heme polymerase activity of Plasmodia and on the in vitro fungal growth are described.

  DOI：

  10.1016/0960-894x(95)00577-g

文献信息

• Roy, Kamal; Bhaduri, A. P., Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 5, p. 489 - 490
  作者：Roy, Kamal、Bhaduri, A. P.

  DOI：——

  日期：——