N-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-formamide | 27984-57-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: N-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-formamide
• 英文别名: N-(1-phenyl-2-pyrazolin-3-yl)formamide；N-(2-phenyl-3,4-dihydropyrazol-5-yl)formamide
• CAS: 27984-57-2
• 化学式: C₁₀H₁₁N₃O
• 分子量: 189.217
• InChiKey: XWWZIEZIQKCMJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-4,5-二氢-1-苯基吡唑 、 甲酸 生成 N-(1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-formamide
  参考文献：
  名称：

  DUSZA, J. P.;JOSEPH, J. P.;BERNSTEIN, S.

  摘要：

  DOI：

文献信息

• 3-Trifluoroacetylamino-1-aryl-2-pyrazolines
  申请人：American Cyanamid Company

  公开号：US04447442A1

  公开（公告）日：1984-05-08

  This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

  本公开说明了新颖的3-取代氨基-1-苯基-2-吡唑烷和3-取代氨基-1-单取代和双取代苯基-2-吡唑烷及其C.sub.4和C.sub.5类似物，可用于改善关节炎疾病的炎症和/或渐进性关节退化特征，预防哮喘症状和过敏性疾病的发生，或作为镇痛剂，抗菌剂或抗真菌剂。
• 3-Trifluoroacetyl amino-1-aryl-2-pyrazolines
  申请人：American Cyanamid Company

  公开号：US04348527A1

  公开（公告）日：1982-09-07

  This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, effective as anti-inflammatory and analgesic agents, and as antibacterial agents and/or antifungal agents.

  本披露描述了新型的3-取代氨基-1-苯基-2-吡唑烷和3-取代氨基-1-单取代和双取代苯基-2-吡唑烷及其C.sub.4和C.sub.5类似物，作为抗炎和镇痛剂以及抗菌剂和/或抗真菌剂具有有效性。
• Heterocyclic substituted-amino-pyrazolines
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0070376A1

  公开（公告）日：1983-01-26

  Novel 3-amino and 3-substituted amino-1-substituted-2-pyrazolines and compositions of matter useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.

  新颖的 3-氨基和 3-取代氨基-1-取代-2-吡唑啉类化合物和物质组合物，可用于改善关节炎疾病特有的炎症和/或进行性关节退化，预防哮喘症状和过敏性疾病的发生，或用作镇痛剂、抗菌剂或抗真菌剂。
• Preparation of aminopyrazolines and intermediates used therein
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0119450A1

  公开（公告）日：1984-09-26

  A process for the preparation of 3-(N-substituted amino)-2-pyrazolines, of formula (I) which comprises (i) reacting of a compound of formula (II) with a compound serving to effect substitution of a group R' on the amino group attached to the 3-position of the pyrazoline ring in the compound of formula (II), thereby to form a compound of formula (III) and converting the compound of formula (III) to a compound of formula (I) or an acid addition salt thereof. Certain of the intermediates of formula (III) are novel and possess pharmacological activity.

  一种制备式(I)的 3-(N-取代氨基)-2-吡唑啉类化合物的工艺，包括(i)式(II)化合物与一种化合物反应，使式(II)化合物中连接在吡唑啉环 3 位上的氨基上的基团 R'发生取代反应，从而形成式(III)化合物，并将式(III)化合物转化为式(I)化合物或其酸加成盐。 某些式(III)中间体具有新颖性和药理活性。
• US4348527A
  申请人：——

  公开号：US4348527A

  公开（公告）日：1982-09-07