methyl 6-(diethylamino)-1-benzofuran-2-carboxylate | 126174-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: methyl 6-(diethylamino)-1-benzofuran-2-carboxylate
• 英文别名: Methyl 6-(N,N-diethylamino)-2benzo[b]furanylcarboxylate；Methyl 6-(diethylamino)benzofuran-2-carboxylate
• CAS: 126174-11-6
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: ZKTUFCFRLOFBMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 6-(diethylamino)-1-benzofuran-2-carboxylate 以82%的产率得到
  参考文献：
  名称：

  CHEN, C. H.;FOX, J. L.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(二乙氨基)水杨醛 以45%的产率得到
  参考文献：
  名称：

  CHEN, C. H.;FOX, J. L.

  摘要：

  DOI：

文献信息

• [EN] ACYL SULFONAMIDES FOR TREATING CANCER<br/>[FR] ACYLSULFONAMIDES POUR LE TRAITEMENT DU CANCER
  申请人：BAYER AG

  公开号：WO2020216701A1

  公开（公告）日：2020-10-29

  The present invention provides acyl sulfonamide compounds of general formula (I): in which X, R1, R2, R3, R4, R5, R6, Ra and Rb are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.

  本发明提供了一般式(I)的酰基磺酰胺化合物：其中X、R1、R2、R3、R4、R5、R6、Ra和Rb如本文所述和定义的那样，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防过度增殖性疾病的药物组合物，作为唯一药剂或与其他活性成分结合使用，以及治疗和/或预防疾病的方法，特别是癌症，更特别是KAT6A和/或KAT6B在局部扩增的癌症，所述方法包括向需要的受试者施用至少一种式(I)化合物的有效量。
• Novel benzofuran dyes
  申请人：Eastman Kodak Company

  公开号：US04948893A1

  公开（公告）日：1990-08-14

  A 6-tertiary amino-2-(Z.dbd.CH--)benzofuran dye is disclosed, where Z represents the atoms providing an electron withdrawing group and a conjugated methine linkage completing a resonant dye chromophore including the 6-tertiary amino group as an electron donor and the electron withdrawing group as an electron acceptor. The dyes are formed by condensing a 6-tertiary amino-2-formylbenzofuran with an electron withdrawing dye nucleus precursor containing an active methyl or methylene site. The dyes exhibit bathochromically shifted absorption peaks.

  揭示了一种6-三级胺-2-(Z.dbd.CH--)苯并呋喃染料，其中Z代表提供电子提取基团和共轭亚甲基键的原子，完成一个谐振染料色团，包括6-三级胺基团作为电子给体和电子提取基团作为电子受体。该染料通过将6-三级胺-2-甲醛苯并呋喃与含有活性甲基或亚甲基位点的电子提取染料核前体缩合而成。该染料表现出波长向红移的吸收峰。
• Benzofuran dyes containing a coumarin nucleus
  申请人：Eastman Kodak Company

  公开号：US04973694A1

  公开（公告）日：1990-11-27

  A 6-tertiary amino-2-(Z.dbd.CH--)benzofuran dye is disclosed, where Z represents the atoms providing an electron withdrawing group and a conjugated methine linkage completing a resonant dye chromophore including the 6-tertiary amino group as an electron donor and the electron withdrawing group as an electron acceptor. The dyes are formed by condensing a 6-tertiary amino-2-formylbenzofuran with an electron withdrawing dye nucleus precursor containing an active methyl or methylene site. The dyes exhibit bathocromically shifted absorption peaks.

  本发明公开了一种6-三级胺-2-(Z.dbd.CH--)苯并呋喃染料，其中Z代表提供电子吸引基团和共轭甲烷键的原子，完成了共振染料色团，包括6-三级胺基团作为电子给体和电子吸引基团作为电子受体。这些染料是通过将6-三级胺-2-甲酰基苯并呋喃与含有活性甲基或亚甲基位点的电子吸引染料核前体缩合而成。这些染料表现出巴托克移位的吸收峰。
• Dye sensitized photographic imaging systems
  申请人：Eastman Kodak Company

  公开号：US04876175A1

  公开（公告）日：1989-10-24

  A photographic imaging system is disclosed comprised of a hardenable organic component containing ethylenic unsaturation sites and coinitiators for ethylenic addition. The coinitiators include an activator and a photosensitizer. The photosensitizer is a 6-tertiary amino-2-(Z--CH.dbd.)benzofuran dye, where Z represents the atoms providing an electron withdrawing carbonyl or sulfonyl group and completing a conjugated methine linkage extending from the electron withdrawing carbonyl group through the benzofuran to the electron donating 6-tertiary amino substituent to form a resonant dye chromophore. The photosensitizers bathochromically extend exposure response of the imaging system.

  公开了一种摄影成像系统，由含有乙烯不饱和位点和乙烯基加成的共同引发剂的可硬化有机组分组成。共同引发剂包括激活剂和光敏剂。光敏剂是一种6-三级胺-2-(Z--CH.dbd.)苯并呋喃染料，其中Z代表提供电子吸引羰基或磺酰基的原子，并通过苯并呋喃到6-三级胺取代基提供电子以形成共振染料色团的共轭亚甲基链。光敏剂向红移延长了成像系统的曝光响应。
• US4900831A
  申请人：——

  公开号：US4900831A

  公开（公告）日：1990-02-13