4-Cyclopropyl-6-ethoxy-5,6-dihydro-4H-pyran-3-carbaldehyde | 132607-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 4-Cyclopropyl-6-ethoxy-5,6-dihydro-4H-pyran-3-carbaldehyde
• 英文别名: 4-cyclopropyl-2-ethoxy-3,4-dihydro-2H-pyran-5-carbaldehyde
• CAS: 132607-17-1
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: SACKSRCWJWKVLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙烯基乙醚 、 2-Cyclopropylmethylene-malonaldehyde 以 乙醚 为溶剂， 生成 4-Cyclopropyl-6-ethoxy-5,6-dihydro-4H-pyran-3-carbaldehyde
  参考文献：
  名称：

  Synthesis of (2,2-diformylethenyl)cycloalkanes and ?-?-bis-(2,2-diformylethenyl)alkanes

  摘要：

  The reaction of dimethylaminomethylenemalonaldehyde with Grignard reagents, which proceeds through 1,4-addition and is accompanied by the loss of the dimethylamino group, gives previously unreported (2,2-diformylethenyl)cycloalkanes and alpha,omega-bis-(2,2-diformylethenyl)alkanes, which were characterized as dihydropyran [4 + 2]-cycloadducts with vinyl ethyl ether.

  DOI：

  10.1007/bf00958284

文献信息

• The first general synthetic approach to aikylidenemalonaldehydes
  作者：Z. Arnold、G.V. Kryshtal、V. Král、D. Dvorˇák、L.A. Yanovskaya

  DOI：10.1016/0040-4039(88)85231-6

  日期：1988.1

  Alkylidenemalonaldehydes, hitherto assumed to be only unstable intermediates of some procedures, have now been made accessible by the reaction of dimethylaminomethylenemalonaldehyde with organometallic compounds.

  迄今被认为只是某些方法的不稳定中间体的亚烷基丙二醛，现在已通过二甲基氨基亚甲基丙二醛与有机金属化合物的反应而获得。
• KRYSHTAL, G. V.;KRAL, V.;DVORZHAK, D.;ARNOLD, Z.;YANOVSKAYA, L. A., IZV. AN CCCP. CEP. XIM.,(1990) N, S. 2172-2175
  作者：KRYSHTAL, G. V.、KRAL, V.、DVORZHAK, D.、ARNOLD, Z.、YANOVSKAYA, L. A.

  DOI：——

  日期：——
• ARNOLD, Z.;KRYSHTAL, G. V.;KRAL, V.;DVORAK, D.;YANOVSKAYA, L. A., TETRAHEDRON. LETT., 29,(1988) N 23, C. 2861-2864
  作者：ARNOLD, Z.、KRYSHTAL, G. V.、KRAL, V.、DVORAK, D.、YANOVSKAYA, L. A.

  DOI：——

  日期：——