2,4-dimethyl-2H-1-benzopyrane | 71649-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,4-dimethyl-2H-1-benzopyrane
• 英文别名: 2,4-dimethyl-2H-chromene；2,4-Dimethyl-2H-chromen；2,4-dimethyl-2H-chromene
• CAS: 71649-79-1
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: FUSXWWHVYKMZGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,6-dimethyl-4,7-dioxatetracyclo[6.4.0.02,6.03,5]dodeca-1(12),8,10-triene 以10%的产率得到
  参考文献：
  名称：

  KURITA, JYOJI;YAMADA, SACHIKO;SAKAI, HIROICHI;TSUCHIYA, TAKASHI, J. CHEM. SOC. CHEM. COMMUN., 1985, N 18, 1254-1255

  摘要：

  DOI：

文献信息

• Synthesis of the first examples of 1,4-benzodioxocines
  作者：Jyoji Kurita、Sachiko Yamada、Hiroichi Sakai、Takashi Tsuchiya

  DOI：10.1039/c39850001254

  日期：——

  vacuum pyrolysis of the 1a,1b,6b,6c-tetrahydro-oxireno[2′,3′:3,4]cyclobuta[1,2-b][1]benzofurans (5), prepared from the benzoxepines (3)via two steps, results in ring-opening to give the novel 1,4-benzodioxocines (6), whose spectral data indicate that they are non-aromatic.

  闪蒸真空热解由苯并恶庚烷（3）制备的1a，1b，6b，6c-四氢-氧杂壬酸[2'，3'：3,4]环丁[1,2- b ] [1]苯并呋喃（5）通过两个步骤，导致开环，得到新颖的1,4-苯并二氧杂环酮（6），其光谱数据表明它们是非芳香族的。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• Aukrust, I.R.; Noushabadi, M.; Skatteboel, L., Polish Journal of Chemistry, 1994, vol. 68, # 11, p. 2167 - 2174
  作者：Aukrust, I.R.、Noushabadi, M.、Skatteboel, L.

  DOI：——

  日期：——
• THE ACTION OF ALKYLMAGNESIUM HALIDES ON COUMARIN AND RELATED COMPOUNDS. SYNTHESIS OF 2,2-DIALKYL-1,2-BENZOPYRANS
  作者：R. L. SHRINER、A. G. SHARP

  DOI：10.1021/jo01217a007

  日期：1939.11
• METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nishino Taito

  公开号：US20100266556A1

  公开（公告）日：2010-10-21

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.