6-benzyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one | 68283-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 6-benzyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
• 英文别名: 6-benzyl-imidazo[1,5-d]-as-triazin-4(3H)-one；6-benzyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
• CAS: 68283-00-1
• 化学式: C₁₂H₁₀N₄O
• 分子量: 226.238
• InChiKey: OBIGLMYNFAYRRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-benzyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one 在 溴 、 sodium hydride 作用下， 以 叔丁醇 为溶剂， 反应 4.25h， 生成 3-Allyl-6-benzyl-8-bromo-3H-imidazo[1,5-d][1,2,4]triazin-4-one
  参考文献：
  名称：

  Imidazo[1,5-d][1,2,4]triazines as potential antiasthma agents

  摘要：

  By using inhibition of histamine release from antigen-challenged, sensitized human basophils as a means of identifying a potentially prophylactic drug for the treatment of asthma, a series of substituted imidazo[1,5-d][1,2,4]triazines were found, which were active. These compounds were prepared by treating imidazolecarboxaldehydes with excess Grignard agent and then oxidizing the resulting alcohols to ketones with Jones reagent. Pyrolysis of a mixture of ketone and methyl carbazate at 200 degrees C in diphenyl ether produced the desired imidazo[1,5-d][1,2,4]triazines. Those compounds with the greatest basophil activity were tested for in vivo activity in the mouse passive cutaneous anaphylaxis (PCA) and the guinea pig passive anaphylaxis tests. The best compounds, 1-ethyl-8-methyl-6-propylimidazo[1,5-d][1,2,4]triazin-4(3H)- one (4-17) and 1,8-dimethyl-6-propylimidazo[1,5-d][1,2,4]triazin-4-(3H)-one (4-16) were chosen for further study.

  DOI：

  10.1021/jm00149a029
• 作为产物：
  描述：

  2-苄基-1H-咪唑-5-甲醛 以 二苯醚 、 乙醇 为溶剂， 生成 6-benzyl-3H-imidazo[1,5-d][1,2,4]triazin-4-one
  参考文献：
  名称：

  Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones

  摘要：

  提供了替代的咪唑[1,5-d]-嘧啶-4(3H)-酮和替代的咪唑[1,5-d]-嘧啶-4(3H)-硫酮，可用作环磷酸腺苷磷酸二酯酶的抑制剂和广谱除草剂。

  公开号：

  US04107307A1

文献信息

• Method for the control of undesired plant species using
  申请人：American Cyanamid Company

  公开号：US04168964A1

  公开（公告）日：1979-09-25

  This disclosure describes herbicidal methods for the pre- and postemergence control of undesired mono- and dicotyledonous plants using substituted imidazo[1,5-d]-as-triazin-4(3H)-ones and substituted imidazo[1,5-d]-as-triazine-4(3H)-thiones.

  本公开描述了使用取代的咪唑[1,5-d]-嘧啶-4(3H)-酮和取代的咪唑[1,5-d]-嘧啶-4(3H)-硫醚来进行对不受欢迎的单子叶和双子叶植物的前期和后期除草的除草方法。
• Substituted 3-(4-imidazolylmethylene)carbazic and thiocarbazic acid
  申请人：American Cyanamid Company

  公开号：US04124766A1

  公开（公告）日：1978-11-07

  There are provided substituted 3-(4-imidazolyl-methylene)carbazic acid esters and 3-(4-imidazolylmethylene)dithiocarbazic acid esters useful as intermediates for the preparation of compounds which inhibit the enzyme cyclic-AMP phosphodiesterase.

  提供了3-(4-咪唑基亚甲基)咔巴酸酯和3-(4-咪唑基亚甲基)二硫咔巴酸酯，用作制备抑制酶环磷酸腺苷磷酸二酯酶的化合物的中间体。
• Apple tree named ‘Gala 0502B’
  申请人：KIKU SRL GmbH

  公开号：USPP030511P3

  公开（公告）日：2019-05-21

  ‘Gala 0502B’ apple is ‘Gala’ sport notable for its fruit, which attains a distinctive, deep purple-red color well before harvest. ‘Gala 0502B’ can be harvested in a single picking due to its early intense and even coloration.

  “Gala 0502B”苹果是一种以果实著名的“Gala”变种，果实在收获前就能呈现出深紫红色的独特颜色。由于早期的强烈均匀着色，‘Gala 0502B’可以在一次采摘中收获。
• US30511
  申请人：——

  公开号：——

  公开（公告）日：——
• PAUL, R.;BROCKMAN, J. A.;HALLETT, W. A.;HANIFIN, J. W.;TARRANT, M. E.;TOR+, J. MED. CHEM., 1985, 28, N 11, 1704-1716
  作者：PAUL, R.、BROCKMAN, J. A.、HALLETT, W. A.、HANIFIN, J. W.、TARRANT, M. E.、TOR+

  DOI：——

  日期：——