4-acetyl-4-methoxy-1-(2-ethoxyethyl)piperidine | 625833-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-acetyl-4-methoxy-1-(2-ethoxyethyl)piperidine
• 英文别名: Ethanone, 1-[1-(2-ethoxyethyl)-4-methoxy-4-piperidinyl]-；1-[1-(2-ethoxyethyl)-4-methoxypiperidin-4-yl]ethanone
• CAS: 625833-38-7
• 化学式: C₁₂H₂₃NO₃
• 分子量: 229.32
• InChiKey: SSGLCPSMQLSXFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-acetyl-4-methoxy-1-(2-ethoxyethyl)piperidine 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以82%的产率得到4-(1-hydroxyethyl)-4-methoxy-1-(2-ethoxyethyl)piperidine
  参考文献：
  名称：

  Synthesis of Secondary Alcohols and Their Esters from 4-Alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines

  摘要：

  4-Alkoxy-4-(1-hydroxyethyl)-1-(2-ethoxyethyl)piperidines were prepared by reduction of 4-alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines. The esters of the hydroxyethyl derivatives were prepared. The presence of an asymmetric carbon atom in the molecules of the carbinols and their esters results in complication of their 1H NMR spectra.

  DOI：

  10.1007/s11176-005-0243-9
• 作为产物：
  描述：

  4-methoxy-4-ethynyl-1-(2-ethoxyethyl)piperidine 在 硫酸 、 mercury(II) sulfate 、 锌 作用下， 以 水 为溶剂， 反应 6.0h， 以88%的产率得到4-acetyl-4-methoxy-1-(2-ethoxyethyl)piperidine
  参考文献：
  名称：

  Synthesis of Secondary Alcohols and Their Esters from 4-Alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines

  摘要：

  4-Alkoxy-4-(1-hydroxyethyl)-1-(2-ethoxyethyl)piperidines were prepared by reduction of 4-alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines. The esters of the hydroxyethyl derivatives were prepared. The presence of an asymmetric carbon atom in the molecules of the carbinols and their esters results in complication of their 1H NMR spectra.

  DOI：

  10.1007/s11176-005-0243-9

文献信息

• Synthesis of Secondary Alcohols and Their Esters from 4-Alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines
  作者：K. D. Praliev、I. A. Poplavskaya、B. Zh. Nauyryzova、M. A. Baimurzina、K. D. Botbaeva

  DOI：10.1007/s11176-005-0243-9

  日期：2005.3

  4-Alkoxy-4-(1-hydroxyethyl)-1-(2-ethoxyethyl)piperidines were prepared by reduction of 4-alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines. The esters of the hydroxyethyl derivatives were prepared. The presence of an asymmetric carbon atom in the molecules of the carbinols and their esters results in complication of their 1H NMR spectra.