BE-19412B

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: BE-19412B
• 英文别名: 20-chloro-1,17-dihydroxy-3,19,21-trimethoxy-7,24-dimethyl-6-azahexacyclo[12.12.0.02,11.04,9.016,25.018,23]hexacosa-2(11),3,7,9,16,18,20,22,24-nonaene-5,15,26-trione
• 化学式: C₃₀H₂₆ClNO₈
• 分子量: 563.991
• InChiKey: OTPGVWCTROIMAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  40
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  11-Chloro-9,10,12,15a-tetrahydroxy-16-methoxy-3,14-dimethyl-6,7,7a,15a-tetrahydro-2H-2-aza-hexaphene-1,8,15-trione 、 三甲基硅烷化重氮甲烷 以 甲醇 、 正己烷 、 乙酸乙酯 为溶剂， 反应 6.5h， 以250.0 mg的产率得到BE-19412B
  参考文献：
  名称：

  A New Antitumor Antibiotic, BE-19412A, Produced by a Streptomycete.

  摘要：

  A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.

  DOI：

  10.7164/antibiotics.51.908

文献信息

• A New Antitumor Antibiotic, BE-19412A, Produced by a Streptomycete.
  作者：MASAO TSUKAMOTO、SHIGERU NAKAJIMA、HIROHARU ARAKAWA、YASUYUKI SUGIURA、HAJIME SUZUKI、MIOKO HIRAYAMA、SEIGO KAMIYA、YOSHIHIRO TESHIMA、HISAO KONDO、KATSUHISA KOJIRI、HIROYUKI SUDA

  DOI：10.7164/antibiotics.51.908

  日期：——

  A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.