2-(4-Pyridin-2-yl-piperazin-1-ylmethylene)-malononitrile | 195243-38-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-Pyridin-2-yl-piperazin-1-ylmethylene)-malononitrile
• 英文别名: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methylene]propanedinitrile；2-[(4-pyridin-2-ylpiperazin-1-yl)methylidene]propanedinitrile
• CAS: 195243-38-0
• 化学式: C₁₃H₁₃N₅
• 分子量: 239.28
• InChiKey: FYOUTMPARLRIJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2-吡啶基)哌嗪 、 2-(Ethoxyamino-methylene)-malononitrile 以 乙醇 为溶剂， 生成 2-(4-Pyridin-2-yl-piperazin-1-ylmethylene)-malononitrile
  参考文献：
  名称：

  1,1′-Dicyano-2-substituted ethylenes: A new class of glucose uptake inhibitors in antifilarial chemotherapy

  摘要：

  Several 1,1'-dicyano-2-substituted ethylenes (2-16) were synthesized and evaluated for in vivo antifilarial activity. Some of the screened compounds showed significant antifilarial response against Acanthocheilonema viteae in rodents. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00322-3

文献信息

• 1,1′-Dicyano-2-substituted ethylenes: A new class of glucose uptake inhibitors in antifilarial chemotherapy
  作者：Swati Tewari、P.M.S. Chauhan、A.P. Bhaduri、S.N. Singh、Nigar Fatma、R.K. Chatterjee、V.M.L. Srivastava

  DOI：10.1016/s0960-894x(97)00322-3

  日期：1997.7

  Several 1,1'-dicyano-2-substituted ethylenes (2-16) were synthesized and evaluated for in vivo antifilarial activity. Some of the screened compounds showed significant antifilarial response against Acanthocheilonema viteae in rodents. (C) 1997 Elsevier Science Ltd.