5-(2-{4-[2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl]piperazin-1-yl}ethoxy)-1H-benzo[d]imidazole-2(3H)-thione | 1046790-34-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-(2-{4-[2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl]piperazin-1-yl}ethoxy)-1H-benzo[d]imidazole-2(3H)-thione
• 英文别名: 5-(2-(4-(2-(Trifluoromethyl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)ethoxy)-1H-benzo[d]imidazole-2(3H)-thione；5-[2-[4-[2-(trifluoromethyl)-1H-benzimidazol-4-yl]piperazin-1-yl]ethoxy]-1,3-dihydrobenzimidazole-2-thione
• CAS: 1046790-34-4
• 化学式: C₂₁H₂₁F₃N₆OS
• 分子量: 462.499
• InChiKey: FUSZMMABEJAWOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-benzo[d]imidazole 、 2-[(2-thioxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy]acetaldehyde 在 三乙酰氧基硼氢化钠 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 1.0h， 生成 5-(2-{4-[2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl]piperazin-1-yl}ethoxy)-1H-benzo[d]imidazole-2(3H)-thione
  参考文献：
  名称：

  2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor

  摘要：

  Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and antagonists. Recently, small molecule GnRH antagonists have emerged as potentially new treatments. This article describes the discovery of 2-phenyl-4-piperazinylbenzimidazoles as small molecule GnRH antagonists with nanomolar potency in in vitro binding and functional assays, excellent bioavailability (rat % F > 70) and demonstrated oral activity in a rat model having shown significant serum leuteinizing hormone (LH) suppression. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.024

文献信息

• 2-Phenyl-4-piperazinylbenzimidazoles: Orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor
  作者：Jeffrey C. Pelletier、Murty Chengalvala、Josh Cottom、Irene Feingold、Lloyd Garrick、Daniel Green、Diane Hauze、Christine Huselton、James Jetter、Wenling Kao

  DOI：10.1016/j.bmc.2008.05.024

  日期：2008.7.1

  Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and antagonists. Recently, small molecule GnRH antagonists have emerged as potentially new treatments. This article describes the discovery of 2-phenyl-4-piperazinylbenzimidazoles as small molecule GnRH antagonists with nanomolar potency in in vitro binding and functional assays, excellent bioavailability (rat % F > 70) and demonstrated oral activity in a rat model having shown significant serum leuteinizing hormone (LH) suppression. (c) 2008 Elsevier Ltd. All rights reserved.