(1-isopropylpiperidin-4-yl)acetic acid hydrochloride | 609805-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (1-isopropylpiperidin-4-yl)acetic acid hydrochloride
• 英文别名: 2-(1-Isopropylpiperidin-4-yl)acetic acid hydrochloride；2-(1-propan-2-ylpiperidin-4-yl)acetic acid;hydrochloride
• CAS: 609805-55-2
• 化学式: C₁₀H₁₉NO₂*ClH
• 分子量: 221.727
• InChiKey: LEIVXZXIMGRZMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.0
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1-isopropylpiperidin-4-yl)acetic acid hydrochloride 在 氯化亚砜 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 3-[2-(1-isopropylpiperidin-4-yl)acetylamino]-N-(5-chloropyridin-2-yl)benzofuran-2-carboxamide
  参考文献：
  名称：

  BENZOFURAN DERIVATIVE

  摘要：

  公开号：

  EP1489078B1
• 作为产物：
  描述：

  ethyl (1-isopropyl-piperidin-4-yl)acetate 在 盐酸 、 水 作用下， 反应 24.0h， 生成 (1-isopropylpiperidin-4-yl)acetic acid hydrochloride
  参考文献：
  名称：

  EP1582521

  摘要：

  公开号：

文献信息

• Fused furan compound
  申请人：Kawaguchi Takayuki

  公开号：US20060094724A1

  公开（公告）日：2006-05-04

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R 3 is hydrogen or the like; and, R 4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了式(I)的紧凑呋喃化合物：其中环X是苯、吡啶或类似物；Y是可选取代的氨基、可选取代的环烷基、可选取代的芳基、可选取代的饱和杂环基、可选取代的不饱和杂环基；A是单键、低级烷基、低级烯基亚烷基、低级烯基亚烯基或氧原子；R3是氢或类似物；R4是氢或类似物，或其药学上可接受的盐，其用作药物，特别是作为激活的血凝血酶X抑制剂。
• Benzofuran derivative
  申请人：Kawaguchi Takayuki

  公开号：US20050282808A1

  公开（公告）日：2005-12-22

  The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R 1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R 3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

  本发明提供了一种苯并呋喃衍生物，其化学式为[1]：其中x是公式：—N═或—CH═的基团；Y是可选取的取代氨基、可选取的取代环烷基或可选取的饱和杂环基团；A是单键、可选取的具有双键或位于链的末端的碳链或氧原子；R1是氢原子或卤素原子；环B是可选取的取代苯环；R3是氢原子或其药学上可接受的盐，该化合物作为药物特别是激活的血凝血因子X抑制剂。
• Condensed furan compounds
  申请人：Kawaguchi Takayuki

  公开号：US20090156803A1

  公开（公告）日：2009-06-18

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R 3 is hydrogen or the like; and, R 4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了一种公式（I）的紧凑呋喃化合物：其中环X为苯、吡啶或类似物；Y为可选取代的氨基、可选取代的环烷基、可选取代的芳基、可选取代的饱和杂环基、可选取代的不饱和杂环基；A为单键、低碳烷基、低碳烯基亚甲基、低碳烯基或氧原子；R3为氢或类似物；R4为氢、类似物或药学上可接受的盐，其作为药物特别是作为激活的血凝血酶X抑制剂非常有用。
• Benzofuran Derivatives
  申请人：Kawaguchi Takayuki

  公开号：US20090209511A1

  公开（公告）日：2009-08-20

  The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: —N═ or —CH═; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R 1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R 3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

  本发明提供了式[1]的苯并呋喃衍生物：其中x是式：—N═或—CH═的基团；Y是可选取代的氨基基团、可选取代的环烷基团或可选取代的饱和杂环基团；A是单键、具有双键的碳链（可在链的内部或端部）或氧原子；R1是氢原子或卤原子；环B是可选取代的苯环；R3是氢原子或其药学上可接受的盐，其作为药物特别是作为激活的血凝因子X抑制剂有用。
• FUSED FURAN COMPOUND
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP1582521A1

  公开（公告）日：2005-10-05

  The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; R3 is hydrogen or the like; and , R4 is hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

  本发明提供了一种式（I）的缩合呋喃化合物： 其中，环 X 是苯、吡啶或类似物；Y 是任选取代的氨基、任选取代的环烷基、任选取代的芳基、任选取代的饱和杂环基团、任选取代的不饱和杂环基团；A 是单键、低级亚烷基、低级亚烯基、低级亚烯基或氧原子；R3 是氢或类似物；以及 ，R4 是氢或类似物，或其药学上可接受的盐，可用作药物，特别是用作活化的凝血因子 X 抑制剂。