4-(5-isopropyl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline | 1195064-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(5-isopropyl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline
• 英文别名: 4-(5-propan-2-yl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline
• CAS: 1195064-90-4
• 化学式: C₁₅H₂₃N₃
• 分子量: 245.368
• InChiKey: YWKKBXZJBRZGFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-((1S,4S)-5-isopropyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)aniline 、 2,5-二氮杂双环[2.2.2]辛烷双盐酸盐 生成 4-(5-isopropyl-2,5-diazabicyclo[2.2.2]octan-2-yl)aniline
  参考文献：
  名称：

  FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES

  摘要：

  本发明披露了一种具有以下式子表示的Novel [1.2.4]triazolo [1,5-a] pyrazine和imidazo [1,2-a] pyrazine化合物：这些化合物可以制备成药物组合物，并可用于预防和治疗哺乳动物包括人类的各种疾病，包括但不限于疼痛，炎症等。

  公开号：

  US20090286798A1

文献信息

• Substituted triazolopyrazines useful for the treatment of degenerative and inflammatory diseases
  申请人：Galapagos NV

  公开号：US08012983B2

  公开（公告）日：2011-09-06

  Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明揭示了一种具有以下代表性公式的Novel [1.2.4]triazolo[1,5-a]pyrazine和imidazo[1,2-a]pyrazine化合物：这些化合物可以制备为药物组合物，可以用于预防和治疗哺乳动物包括人类的各种疾病，例如但不限于疼痛、炎症等。
• US8012983B2
  申请人：——

  公开号：US8012983B2

  公开（公告）日：2011-09-06
• [EN] FUSED PYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES<br/>[FR] COMPOSÉS DE PYRAZINE FUSIONNÉE UTILES DANS LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
  申请人：GALAPAGOS NV

  公开号：WO2009135885A1

  公开（公告）日：2009-11-12

  Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: Formula (Ia) or Formula (Ib). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, pain, inflammation, and others.