tert-butyl 4-{[(3-aminopyridin-2-yl)oxy]methyl}piperidine-1-carboxylate | 1286274-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-{[(3-aminopyridin-2-yl)oxy]methyl}piperidine-1-carboxylate
• 英文别名: 1-Boc-4-(((3-Aminopyridin-2-yl)oxy)methyl)piperidine；tert-butyl 4-[(3-aminopyridin-2-yl)oxymethyl]piperidine-1-carboxylate
• CAS: 1286274-50-7
• 化学式: C₁₆H₂₅N₃O₃
• 分子量: 307.393
• InChiKey: INULZHXUJBVTMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  77.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-chloro-N-((1R,2S)-2-fluorocyclopropyl)-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carboxamide 、 tert-butyl 4-{[(3-aminopyridin-2-yl)oxy]methyl}piperidine-1-carboxylate 在 chloro(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II) 2nd generation 、 potassium carbonate 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 1,4-二氧六环 为溶剂， 以35 %的产率得到tert-butyl 4-[({3-[(3-{[(2S)-2-fluorocyclopropyl]carbamoyl}-8-{[(4-methoxyphenyl)methyl](methyl)amino}imidazo[1,2-b]pyridazin-6-yl)amino]pyridin-2-yl}oxy)methyl]piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] TYK2 DEGRADERS AND USES THEREOF
  [FR] AGENTS DE DÉGRADATION DE TYK2 ET LEURS UTILISATIONS

  摘要：

  The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.

  公开号：

  WO2023076161A1
• 作为产物：
  描述：

  tert-butyl 4-{[(3-nitropyridin-2-yl)oxy]methyl}piperidine-1-carboxylate 在 platinum(IV) oxide 、 水 作用下， 以 四氢呋喃 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 以79 %的产率得到tert-butyl 4-{[(3-aminopyridin-2-yl)oxy]methyl}piperidine-1-carboxylate
  参考文献：
  名称：

  [EN] TYK2 DEGRADERS AND USES THEREOF
  [FR] AGENTS DE DÉGRADATION DE TYK2 ET LEURS UTILISATIONS

  摘要：

  The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.

  公开号：

  WO2023076161A1

文献信息

• [EN] 3 - IMIDAZOLYL- INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] 3-IMIDAZOLYL-INDOLES POUR TRAITER LES MALADIES PROLIFÉRATIVES
  申请人：NOVARTIS AG

  公开号：WO2012176123A1

  公开（公告）日：2012-12-27

  The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I), in which: R1, R2, R3 and R4 are as defined in the Summary of the Invention. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
• [EN] TYK2 DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION DE TYK2 ET LEURS UTILISATIONS
  申请人：[en]KYMERA THERAPEUTICS, INC.

  公开号：WO2023076161A1

  公开（公告）日：2023-05-04

  The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.